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14 条记录 (耗时 0.014 秒)

    Methods of decreasing adipose tissue
    1.
    发明授权
    Methods of decreasing adipose tissue 有权
    脂肪组织减少的方法

    公开(公告)号：US08591913B2

    公开(公告)日：2013-11-26

    申请号：US13356456

    申请日：2012-01-23

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki

    IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/4703 ,  A23L2/66 ,  A23L33/17 ,  A61K38/00

    摘要： A pharmaceutical composition including, as an active ingredient, one of the following proteins (I) and (II): (I) an apoptosis inhibitor of macrophage; and (II) a protein which consists of an amino acid sequence having deletion, substitution, or addition of one or more amino acids in an amino acid sequence of the apoptosis inhibitor of macrophage and having homology to the amino acid sequence of the apoptosis inhibitor of macrophage, and has a function of inhibiting the differentiation of preadipocytes to mature adipocytes and/or a function of inducing lipolysis in the mature adipocytes.

    摘要翻译： 一种药物组合物，其包含以下蛋白质（I）和（II）作为活性成分：（I）巨噬细胞的凋亡抑制剂; 和（II）由巨噬细胞凋亡抑制剂的氨基酸序列中具有缺失，取代或添加一个或多个氨基酸的氨基酸序列组成的蛋白质，并且与细胞凋亡抑制剂的氨基酸序列具有同源性 并且具有抑制前脂肪细胞分化为成熟脂肪细胞的功能和/或在成熟脂肪细胞中诱导脂肪分解的功能。

    METHOD FOR EXAMINING RENAL DISEASE
    6.
    发明申请
    METHOD FOR EXAMINING RENAL DISEASE 审中-公开

    公开(公告)号：US20180224437A1

    公开(公告)日：2018-08-09

    申请号：US15749696

    申请日：2016-06-01

    申请人： Toru Miyazaki ,  SEKISUI MEDICAL CO., LTD.

    发明人： Toru Miyazaki

    IPC分类号： G01N33/543 ,  G01N33/68

    CPC分类号： G01N33/543 ,  G01N33/6893 ,  G01N2333/70596 ,  G01N2800/347 ,  G01N2800/56

    摘要： A method for detecting renal disease or a method for assisting diagnosis of renal disease that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting renal disease or a method for assisting diagnosis of renal disease comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of renal disease comprising an antibody that binds to free AIM.

    PHARMACEUTICAL COMPOSITION, FOOD OR DRINK, AND METHODS RELATED THERETO
    7.
    发明申请
    PHARMACEUTICAL COMPOSITION, FOOD OR DRINK, AND METHODS RELATED THERETO 有权
    药物组合物，食品或饮料及其相关方法

    公开(公告)号：US20120202747A1

    公开(公告)日：2012-08-09

    申请号：US13356456

    申请日：2012-01-23

    申请人： Toru MIYAZAKI

    发明人： Toru MIYAZAKI

    IPC分类号： A61K38/17 ,  A61P3/04

    CPC分类号： C07K14/4703 ,  A23L2/66 ,  A23L33/17 ,  A61K38/00

    摘要： A pharmaceutical composition including, as an active ingredient, one of the following proteins (I) and (II): (I) an apoptosis inhibitor of macrophage; and (II) a protein which consists of an amino acid sequence having deletion, substitution, or addition of one or more amino acids in an amino acid sequence of the apoptosis inhibitor of macrophage and having homology to the amino acid sequence of the apoptosis inhibitor of macrophage, and has a function of inhibiting the differentiation of preadipocytes to mature adipocytes and/or a function of inducing lipolysis in the mature adipocytes.

    摘要翻译： 一种药物组合物，其包含以下蛋白质（I）和（II）作为活性成分：（I）巨噬细胞的凋亡抑制剂; 和（II）由巨噬细胞凋亡抑制剂的氨基酸序列中具有缺失，取代或添加一个或多个氨基酸的氨基酸序列组成的蛋白质，并且与细胞凋亡抑制剂的氨基酸序列具有同源性 并且具有抑制前脂肪细胞分化为成熟脂肪细胞的功能和/或在成熟脂肪细胞中诱导脂肪分解的功能。

    VARIANT AIM
    8.
    发明公开
    VARIANT AIM 审中-公开

    公开(公告)号：US20230212238A1

    公开(公告)日：2023-07-06

    申请号：US18050245

    申请日：2022-10-27

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki ,  Satoko Arai

    IPC分类号： C12P21/02 ,  C07K14/705

    CPC分类号： C12P21/02 ,  C07K14/70596

    摘要： The present invention relates to the provision of a recombinant AIM that maintains functions, does not multimerize, and is not inactivated by IgM (e.g., a protein containing an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid, and the like).

    Preventive or therapeutic agent for kidney disease
    9.
    发明授权
    Preventive or therapeutic agent for kidney disease 有权

    公开(公告)号：US11253571B2

    公开(公告)日：2022-02-22

    申请号：US16509161

    申请日：2019-07-11

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki

    IPC分类号： A61K38/17 ,  A61K38/00 ,  C07K14/435 ,  A61K45/06 ,  G01N33/68 ,  A61K31/7088 ,  A01K67/027

    摘要： The present invention provides a prophylactic or therapeutic agent for a kidney disease, comprising Apoptosis Inhibitor of Macrophage (AIM) or a partial peptide thereof, or a nucleic acid comprising a base sequence encoding the same, or a screening method for a prophylactic or therapeutic agent for a kidney disease, comprising using an animal obtained by subjecting a non-human mammal deficient in AIM expression to unilateral ureteral obstruction or transient kidney ischemia/reperfusion and the like.