公开(公告)号：US20190317096A1

公开(公告)日：2019-10-17

申请号：US15757014

申请日：2016-09-09

申请人： Toru Miyazaki ,  SEKISUI MEDICAL CO., LTD. ,  SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.

发明人： Toru Miyazaki ,  Takeshi Okanoue ,  Noriyuki Koyama

IPC分类号： G01N33/574

摘要： A method for examining liver cancer or a method for assisting diagnosis of liver cancer that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting liver cancer or a method for assisting diagnosis of liver cancer comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of liver cancer comprising an antibody that binds to free AIM.

公开(公告)号：US20210123917A1

公开(公告)日：2021-04-29

申请号：US17135168

申请日：2020-12-28

申请人： Toru Miyazaki ,  SEKISUI MEDICAL CO., LTD. ,  SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.

发明人： Toru Miyazaki ,  Takeshi Okanoue ,  Noriyuki Koyama

IPC分类号： G01N33/574

摘要： A method for examining liver cancer or a method for assisting diagnosis of liver cancer that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting liver cancer or a method for assisting diagnosis of liver cancer comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of liver cancer comprising an antibody that binds to free AIM.

公开(公告)号：US20180100867A1

公开(公告)日：2018-04-12

申请号：US15565027

申请日：2016-04-08

申请人： Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc. ,  Sumitomo Dainippon Pharma Co., Ltd.

发明人： Takeshi Okanoue ,  Keito Yoshimura ,  Tsuyoshi Iwasaki ,  Kazuto Yamazaki ,  Hayao Ebise ,  Junji Ichihara

IPC分类号： G01N33/68 ,  G01N21/27 ,  G01N33/49 ,  G01N33/74 ,  G01N33/92

CPC分类号： G01N33/6893 ,  G01N21/27 ,  G01N33/48 ,  G01N33/483 ,  G01N33/492 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/74 ,  G01N33/743 ,  G01N33/92 ,  G01N2333/70542 ,  G01N2800/085 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  G01N2800/7052 ,  G16H50/20

摘要： Provided is a noninvasive method for determining the presence of a symptom of a hepatic disease such as nonalcoholic fatty liver disease with a higher diagnostic accuracy. A method for discriminate between nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), the method comprising: (1) a step of measuring the quantities of marker molecules contained in blood collected from a subject; (2) a step of determining an index value from a normalized score calculated based on the quantities of the marker molecules belonging to the same group; and (3) a step of determining that the subject is possibly affected with NASH in the case that the index value is larger than a reference value.