公开(公告)号：US20190317096A1

公开(公告)日：2019-10-17

申请号：US15757014

申请日：2016-09-09

申请人： Toru Miyazaki ,  SEKISUI MEDICAL CO., LTD. ,  SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.

发明人： Toru Miyazaki ,  Takeshi Okanoue ,  Noriyuki Koyama

IPC分类号： G01N33/574

摘要： A method for examining liver cancer or a method for assisting diagnosis of liver cancer that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting liver cancer or a method for assisting diagnosis of liver cancer comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of liver cancer comprising an antibody that binds to free AIM.

公开(公告)号：US20180224437A1

公开(公告)日：2018-08-09

申请号：US15749696

申请日：2016-06-01

申请人： Toru Miyazaki ,  SEKISUI MEDICAL CO., LTD.

发明人： Toru Miyazaki

IPC分类号： G01N33/543 ,  G01N33/68

CPC分类号： G01N33/543 ,  G01N33/6893 ,  G01N2333/70596 ,  G01N2800/347 ,  G01N2800/56

摘要： A method for detecting renal disease or a method for assisting diagnosis of renal disease that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting renal disease or a method for assisting diagnosis of renal disease comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of renal disease comprising an antibody that binds to free AIM.

公开(公告)号：US10996217B2

公开(公告)日：2021-05-04

申请号：US15749696

申请日：2016-06-01

申请人： SEKISUI MEDICAL CO., LTD. ,  Toru Miyazaki

发明人： Toru Miyazaki

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/68

摘要： A method for detecting renal disease or a method for assisting diagnosis of renal disease that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting renal disease or a method for assisting diagnosis of renal disease comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of renal disease comprising an antibody that binds to free AIM.

公开(公告)号：US20210123917A1

公开(公告)日：2021-04-29

申请号：US17135168

申请日：2020-12-28

申请人： Toru Miyazaki ,  SEKISUI MEDICAL CO., LTD. ,  SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.

发明人： Toru Miyazaki ,  Takeshi Okanoue ,  Noriyuki Koyama

IPC分类号： G01N33/574

摘要： A method for examining liver cancer or a method for assisting diagnosis of liver cancer that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting liver cancer or a method for assisting diagnosis of liver cancer comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of liver cancer comprising an antibody that binds to free AIM.

公开(公告)号：US11866471B2

公开(公告)日：2024-01-09

申请号：US16764755

申请日：2018-10-09

申请人： Toru Miyazaki

发明人： Toru Miyazaki ,  Satoko Arai

IPC分类号： C07K14/47 ,  C12N15/63 ,  A61K38/00 ,  C07K14/705 ,  C12P21/02

CPC分类号： C07K14/4702 ,  C07K14/70596 ,  C12N15/63 ,  C12P21/02 ,  A61K38/00

摘要： The present invention relates to the provision of a recombinant AIM that maintains functions, does not multimerize, and is not inactivated by IgM (e.g., a protein containing an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid, and the like).

公开(公告)号：US08591913B2

公开(公告)日：2013-11-26

申请号：US13356456

申请日：2012-01-23

申请人： Toru Miyazaki

发明人： Toru Miyazaki

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/18 ,  C07K14/475

CPC分类号： C07K14/4703 ,  A23L2/66 ,  A23L33/17 ,  A61K38/00

摘要： A pharmaceutical composition including, as an active ingredient, one of the following proteins (I) and (II): (I) an apoptosis inhibitor of macrophage; and (II) a protein which consists of an amino acid sequence having deletion, substitution, or addition of one or more amino acids in an amino acid sequence of the apoptosis inhibitor of macrophage and having homology to the amino acid sequence of the apoptosis inhibitor of macrophage, and has a function of inhibiting the differentiation of preadipocytes to mature adipocytes and/or a function of inducing lipolysis in the mature adipocytes.

摘要翻译： 一种药物组合物，其包含以下蛋白质（I）和（II）作为活性成分：（I）巨噬细胞的凋亡抑制剂; 和（II）由巨噬细胞凋亡抑制剂的氨基酸序列中具有缺失，取代或添加一个或多个氨基酸的氨基酸序列组成的蛋白质，并且与细胞凋亡抑制剂的氨基酸序列具有同源性 并且具有抑制前脂肪细胞分化为成熟脂肪细胞的功能和/或在成熟脂肪细胞中诱导脂肪分解的功能。

公开(公告)号：US08012798B2

公开(公告)日：2011-09-06

申请号：US12774031

申请日：2010-05-05

申请人： Toru Miyazaki

发明人： Toru Miyazaki

IPC分类号： H01L21/00 ,  H01L23/48

CPC分类号： H01L21/76898 ,  H01L23/481 ,  H01L24/11 ,  H01L24/13 ,  H01L24/14 ,  H01L24/81 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/0401 ,  H01L2224/0557 ,  H01L2224/13009 ,  H01L2224/13025 ,  H01L2224/1308 ,  H01L2224/13082 ,  H01L2224/13111 ,  H01L2224/13147 ,  H01L2224/81191 ,  H01L2224/81193 ,  H01L2224/81203 ,  H01L2224/81801 ,  H01L2225/06513 ,  H01L2225/06517 ,  H01L2225/06541 ,  H01L2924/00013 ,  H01L2924/0002 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01019 ,  H01L2924/01022 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01074 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/13091 ,  H01L2924/15788 ,  H01L2924/00014 ,  H01L2224/13099 ,  H01L2924/00 ,  H01L2224/05552

摘要： A method for manufacturing a semiconductor device includes forming a first opening in a substrate to expose an interconnect structure, forming a seed film on the substrate, forming a first projecting electrode buried inside the first opening protruding outward from the substrate, forming a first metal film on the first projecting electrode, attaching a first supporting substrate to the substrate with a first adhesion layer, forming a second opening in the substrate to expose the interconnect structure, forming a second projecting electrode buried inside the second opening and protruding outward from the substrate, forming a second metal film on the second projecting electrode, attaching a second supporting substrate to the substrate with a second adhesion layer, removing the first supporting substrate, the first adhesion layer, and an exposed part of the seed film, removing the second supporting substrate and the second adhesion layer, and cutting the substrate into the plurality of chips.

摘要翻译： 一种半导体器件的制造方法，其特征在于，在基板上形成第一开口以露出互连结构，在所述基板上形成种子膜，形成埋设在从所述基板向外突出的所述第一开口内的第一突出电极，形成第一金属膜 在第一突出电极上，用第一粘合层将第一支撑基板附着到基板上，在基板中形成第二开口以露出互连结构，形成埋在第二开口内并从基板向外突出的第二突出电极， 在所述第二突出电极上形成第二金属膜，用第二粘合层将第二支撑基板附接到所述基板，去除所述第一支撑基板，所述第一粘合层和所述种子膜的暴露部分，去除所述第二支撑基板 和第二粘合层，并将基板切割成多个ch ips。

公开(公告)号：US07821060B2

公开(公告)日：2010-10-26

申请号：US12219197

申请日：2008-07-17

申请人： Yoshihiro Kitamura ,  Toru Miyazaki

发明人： Yoshihiro Kitamura ,  Toru Miyazaki

IPC分类号： H01L29/76

CPC分类号： H01L29/66621 ,  H01L21/28061 ,  H01L21/28114 ,  H01L21/28123 ,  H01L21/3247 ,  H01L27/10876 ,  H01L29/1037 ,  H01L29/42376 ,  H01L29/4933 ,  H01L29/78

摘要： A semiconductor device includes an active region having a groove, a gate insulating film, and a gate electrode. The gate electrode may include first and second layers. The first layer extends along the gate insulating film. The first layer is electrically conductive. The second layer extends along the first layer. The second layer is separate from the gate insulating film by the first layer.

摘要翻译： 半导体器件包括具有凹槽的有源区，栅极绝缘膜和栅电极。 栅电极可以包括第一层和第二层。 第一层沿着栅极绝缘膜延伸。 第一层是导电的。 第二层沿着第一层延伸。 第二层与第一层与栅极绝缘膜分开。

公开(公告)号：US20230212238A1

公开(公告)日：2023-07-06

申请号：US18050245

申请日：2022-10-27

申请人： Toru Miyazaki

发明人： Toru Miyazaki ,  Satoko Arai

IPC分类号： C12P21/02 ,  C07K14/705

CPC分类号： C12P21/02 ,  C07K14/70596

摘要： The present invention relates to the provision of a recombinant AIM that maintains functions, does not multimerize, and is not inactivated by IgM (e.g., a protein containing an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid, and the like).

公开(公告)号：US11253571B2

公开(公告)日：2022-02-22

申请号：US16509161

申请日：2019-07-11

申请人： Toru Miyazaki

发明人： Toru Miyazaki

IPC分类号： A61K38/17 ,  A61K38/00 ,  C07K14/435 ,  A61K45/06 ,  G01N33/68 ,  A61K31/7088 ,  A01K67/027

摘要： The present invention provides a prophylactic or therapeutic agent for a kidney disease, comprising Apoptosis Inhibitor of Macrophage (AIM) or a partial peptide thereof, or a nucleic acid comprising a base sequence encoding the same, or a screening method for a prophylactic or therapeutic agent for a kidney disease, comprising using an animal obtained by subjecting a non-human mammal deficient in AIM expression to unilateral ureteral obstruction or transient kidney ischemia/reperfusion and the like.