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公开(公告)号：US20240318024A1
公开(公告)日：2024-09-26
申请号：US18678505
申请日：2024-05-30
发明人： Deepa MADAN , Priyanshu BANERJEE , Jiyuan HUANG
IPC分类号： C09D105/00 , C09D11/08
CPC分类号： C09D105/00 , C09D11/08
摘要： An energy-efficient method of controlling the composite microstructure and resulting thermoelectric (TE) properties of TE composite films. The TE composite films, which include a small amount of naturally occurring chitosan binder that is sufficient to hold TE particles together, are modified by applying uniaxial mechanical pressure at low temperatures for a short duration. The TE composite films have high electrical conductivity and low thermal conductivity, making them ideal for use into high-performance energy harvesting thermoelectric devices.
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公开(公告)号：US20240299428A1
公开(公告)日：2024-09-12
申请号：US18661922
申请日：2024-05-13
发明人： Katherine L. RADTKE
IPC分类号： A61K31/683 , A61K31/506 , A61K31/675 , A61K45/06
CPC分类号： A61K31/683 , A61K31/506 , A61K31/675 , A61K45/06
摘要： The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
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公开(公告)号：US20240295459A1
公开(公告)日：2024-09-05
申请号：US18437773
申请日：2024-02-09
发明人： Weidong ZHU , Linfeng LYU
摘要： A one-dimensional (1D) and two-dimensional (2D) scan scheme for a tracking continuously scanning laser Doppler vibrometer (CSLDV) system to scan the whole surface of a rotating structure excited by a random force. A tracking CSLDV system tracks a rotating structure and sweep its laser spot on its surface. The measured response of the structure using the scan scheme of the tracking CSLDV system is considered as the response of the whole surface of the structure subject to random excitation. The measured response can be processed by operational modal analysis (OMA) methods (e.g., an improved lifting method, an improved demodulation method, an improved 2D demodulation method). Damped natural frequencies of the rotating structure are estimated from the fast Fourier transform of the measured response. Undamped full-field mode shapes are estimated by multiplying the measured response using sinusoids whose frequencies are estimated damped natural frequencies.
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公开(公告)号：US20240282455A1
公开(公告)日：2024-08-22
申请号：US18583009
申请日：2024-02-21
发明人： Justin Brooks , Jan Ver Eecke , Sarah Conklin , Jessica Dietch
摘要： Methods, systems, and devices for analyzing objective health data and subject-conveyed health information are disclosed for health information reporting, treatment planning, diagnoses, and treatment. According to an aspect, a method can include receiving objective health data of a subject. Further, the method can include receiving a first set of information about the subject's health. The first set of information was conveyed by the subject. The method includes presenting the objective health data to the subject. The method includes receiving, subsequent to presentation of the objective health data to the subject, a second set of information about the subject's health, wherein the second set of information was conveyed by the subject. The method can also include analyzing the objective health data, the first set of information, and the second set of information. Further, the method can include determining a treatment plan, diagnosis, and/or health information based on the analysis.
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5.发明公开公开(公告)号：US20240192081A1
公开(公告)日：2024-06-13
申请号：US18539064
申请日：2023-12-13
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY , NATIONAL AERONAUTICS AND SPACE ADMINISTRATION LANGLEY RESEARCH CENTER
发明人： Myung K. SUNG , Soobum Lee , Jude Persia , Devin E. Burns
CPC分类号： G01M9/062 , G01L1/2262 , G01L1/2287
摘要： This present disclosure is about a wind tunnel balance axial section. A wind tunnel balance is a sensor that measures six force/moment components from a test model in a wind tunnel. An axial section, one of the six measurement sections in the balance, is the hardest section to design because it is often required to measure an axial force which is much smaller than other force components. Therefore, there is a specific design requirement for the axial section to selectively amplify the axial force response and suppress the non-axial responses. This disclosure presents a sensor mechanism composed of elastic linkages to achieve this design requirements for the axial section.
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公开(公告)号：US11708553B2
公开(公告)日：2023-07-25
申请号：US16618473
申请日：2018-06-07
发明人： Govind Rao , Yordan Kostov , Abhay Andar , Mustafa Al-Adhami , Sevda Deldari , Douglas D. Frey
CPC分类号： C12M23/16 , A61K38/00 , C12M23/44 , C12M27/00 , C12M29/20 , C12M33/14 , C12M41/12 , C12M41/26 , C12M41/28 , C12M41/40
摘要： The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.
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7.发明授权公开(公告)号：US11702625B2
公开(公告)日：2023-07-18
申请号：US17376439
申请日：2021-07-15
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Xudong Ge , Douglas Frey
摘要： A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
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公开(公告)号：US11685892B2
公开(公告)日：2023-06-27
申请号：US17055149
申请日：2019-05-15
摘要： The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.
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公开(公告)号：US20230126566A1
公开(公告)日：2023-04-27
申请号：US18048567
申请日：2022-10-21
发明人： Weidong ZHU , Linfeng LYU
摘要： A one-dimensional (1D) and two-dimensional (2D) scan scheme for a tracking continuously scanning laser Doppler vibrometer (CSLDV) system to scan the whole surface of a rotating structure excited by a random force. A tracking CSLDV system tracks a rotating structure and sweep its laser spot on its surface. The measured response of the structure using the scan scheme of the tracking CSLDV system is considered as the response of the whole surface of the structure subject to random excitation. The measured response can be processed by operational modal analysis (OMA) methods (e.g., an improved lifting method, an improved demodulation method, an improved 2D demodulation method). Damped natural frequencies of the rotating structure are estimated from the fast Fourier transform of the measured response. Undamped full-field mode shapes are estimated by multiplying the measured response using sinusoids whose frequencies are estimated damped natural frequencies.
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公开(公告)号：US20220411656A1
公开(公告)日：2022-12-29
申请号：US17706765
申请日：2022-03-29
发明人： Deepa MADAN , Priyanshu BANERJEE , Jiyuan HUANG
摘要： An energy-efficient method of controlling the composite microstructure and resulting thermoelectric (TE) properties of TE composite films. The TE composite films, which include a small amount of naturally occurring chitosan binder that is sufficient to hold TE particles together, are modified by applying uniaxial mechanical pressure at low temperatures for a short duration. The TE composite films have high electrical conductivity and low thermal conductivity, making them ideal for use into high-performance energy harvesting thermoelectric devices.
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