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公开(公告)号：US11788962B2
公开(公告)日：2023-10-17
申请号：US17156915
申请日：2021-01-25
CPC分类号： G01N21/6428 , B01L3/50273 , B01L3/502715 , B01L3/502753 , B01L3/502761 , G01N21/645 , B01L2300/044 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , C12Q2304/22 , G01N21/272 , G01N21/6408 , G01N2021/0112 , G01N2201/0221 , G01N2333/195
摘要： A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
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公开(公告)号：US10948414B2
公开(公告)日：2021-03-16
申请号：US16000935
申请日：2018-06-06
摘要： A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
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3.发明授权公开(公告)号：US10435664B2
公开(公告)日：2019-10-08
申请号：US15966609
申请日：2018-04-30
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Xudong Ge , Douglas Frey
摘要： A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
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4.发明授权公开(公告)号：US09982227B2
公开(公告)日：2018-05-29
申请号：US15095305
申请日：2016-04-11
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Xudong Ge , Douglas Frey
摘要： A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
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公开(公告)号：US11708553B2
公开(公告)日：2023-07-25
申请号：US16618473
申请日：2018-06-07
发明人： Govind Rao , Yordan Kostov , Abhay Andar , Mustafa Al-Adhami , Sevda Deldari , Douglas D. Frey
CPC分类号： C12M23/16 , A61K38/00 , C12M23/44 , C12M27/00 , C12M29/20 , C12M33/14 , C12M41/12 , C12M41/26 , C12M41/28 , C12M41/40
摘要： The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.
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6.发明授权公开(公告)号：US11702625B2
公开(公告)日：2023-07-18
申请号：US17376439
申请日：2021-07-15
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Xudong Ge , Douglas Frey
摘要： A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
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公开(公告)号：US11685892B2
公开(公告)日：2023-06-27
申请号：US17055149
申请日：2019-05-15
摘要： The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.
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8.发明授权公开(公告)号：US10774304B2
公开(公告)日：2020-09-15
申请号：US16660993
申请日：2019-10-23
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Xudong Ge , Douglas Frey , Shayan Gholipour Borhani , David Burgenson
摘要： A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
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