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公开(公告)号：US20210309704A1
公开(公告)日：2021-10-07
申请号：US17040418
申请日：2019-03-22
发明人： Benoit VanHollebeke
摘要： Novel therapeutic agents, particularly those capable of activating (GPR)124/RECK/Frizzled/lipoprotein receptor-related protein (LRP)-mediated Wnt signaling, while not activating Frizzled/LRP-mediated Wnt signaling in the absence of RECK and/or GPR124. The agents are particularly useful for the prevention or treatment of neurovascular disorders or central nervous system (CNS) disorders including neurovascular dysfunction.
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公开(公告)号：US20210259603A1
公开(公告)日：2021-08-26
申请号：US17256736
申请日：2019-06-04
发明人： Mikhail Kissine , Gaétane Deliens
摘要： A method is provided in order to evaluate a risk of child having a neurodevelopmental disorder. Firstly, a first and a second information are shown simultaneously to the child at two different places on a display screen. Then the first and second information are removed from the display screen for a while and meanwhile movements of the eye of the child are tracked and recorded. Next, a third information is displayed on the display screen, at a location where the second information was previously displayed. This sequence is repeated a number of times. Next, a score for the child is established in function of the movements of his eye(s) as recorded while the first and second information were removed from the display screen. This score gives an indication of a risk of neurodevelopmental disorder with the child.
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公开(公告)号：US09689021B2
公开(公告)日：2017-06-27
申请号：US14350646
申请日：2012-10-15
申请人： UNIVERSITÉ DE LIÈGE , UNIVERSITÉ CATHOLIQUE DE LOUVAIN , UNIVERSITÉ LIBRE DE BRUXELLES , UNIVERSITÉ DE MONS-HAINAUT
发明人： Alain Brans , Bernard Joris , Michael Delmarcelle , Jacqueline Marchand , Paul Tulkens , Catherine Hammaecher , Erik Goormaghtigh , Joel De Coninck
CPC分类号： C12Q1/34 , C12N9/86 , G01N33/9446 , G01N2333/986
摘要： The present invention relates to methods for determining the concentration of a free beta-lactam antibiotic in a biological sample. In particular, the present invention relates to methods for measuring a free beta-lactam antibiotic in a biological sample, comprising the steps of: (a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining the concentration of said free beta-lactam antibiotic in said at least one biological sample.
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公开(公告)号：US20140363814A1
公开(公告)日：2014-12-11
申请号：US14356465
申请日：2011-11-15
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6806 , C12Q1/6816 , C12Q2600/112 , C12Q2600/16 , C12Q2527/125
摘要： The present invention provides a method and a kit for detecting a S. pneumoniae nucleic acid in a sample. The method comprises the steps of isolating said nucleic acid and detecting hybridization between the S. pneumoniae nucleic acid and a labeled probe, wherein the detection of hybridization comprises detecting a change in signal from the labeled probe during or after hybridization relative to the labeled probe signal before hybridization. The method of the present invention is characterized in that said nucleic acid is a ribonucleic acid, which isolation comprises the addition of acidic phenol to said sample and the purification of said ribonucleic acid.
摘要翻译： 本发明提供了用于检测样品中肺炎链球菌核酸的方法和试剂盒。 该方法包括分离所述核酸并检测肺炎链球菌核酸与标记探针之间的杂交的步骤，其中杂交检测包括在杂交期间或之后相对于标记的探针信号检测标记的探针的信号变化 杂交前。 本发明的方法的特征在于所述核酸是核糖核酸，其分离包括向所述样品中加入酸性苯酚和所述核糖核酸的纯化。
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公开(公告)号：US20140105823A1
公开(公告)日：2014-04-17
申请号：US14125689
申请日：2012-06-22
申请人： Robert Muller , Decio L. Eizirik , Corine Sermeus , Sophie Laurent , Carmen Burtea , Marie-Claire Beckers , Daisy Flamez
发明人： Robert Muller , Decio L. Eizirik , Corine Sermeus , Sophie Laurent , Carmen Burtea , Marie-Claire Beckers , Daisy Flamez
IPC分类号： C07K14/00 , A61K49/00 , G01N33/569
CPC分类号： C07K14/001 , A61K49/0004 , C07K14/4713 , G01N33/56966
摘要： The present invention provides a synthetic peptide molecule that specifically binds an FXYD2-gamma isoform of pancreatic beta cells, said synthetic peptide molecule has 25 amino acids.
摘要翻译： 本发明提供了特异性结合胰腺β细胞的FXYD2-γ同种型的合成肽分子，所述合成肽分子具有25个氨基酸。
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公开(公告)号：US12123877B2
公开(公告)日：2024-10-22
申请号：US16494223
申请日：2018-03-16
IPC分类号： G01N33/574
CPC分类号： G01N33/57492 , G01N2333/70589
摘要： The application discloses CD321 as a useful global marker of circulating tumor cells (CTCs) and provides related methods and kits of parts relying on detection of CD321.5.
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7.发明公开公开(公告)号：US20240183857A1
公开(公告)日：2024-06-06
申请号：US18553044
申请日：2022-03-29
发明人： Esteban Gurzov , Wei Wu
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N2333/916 , G01N2800/50 , G01N2800/52
摘要： This application discloses in vitro methods for the diagnosis, prognosis, and/or monitoring of cancer, in particular liver cancer or hepatocellular carcinoma (HCC) based on the aggregate expression level and oxidation level of all protein tyrosine phosphatases in a sample; whether or not in combination with the differential expression of protein tyrosine phosphatases individually. Also provided are in vitro methods for the selection of a prophylactic or therapeutic treatment or the evaluate the efficacy of a therapeutic treatment. Further, the present application provides a kit to be used in said methods.
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公开(公告)号：US20230399369A1
公开(公告)日：2023-12-14
申请号：US18304018
申请日：2023-04-20
发明人： Benoit VANHOLLEBEKE
CPC分类号： C07K14/4705 , A61P25/00 , G01N33/5041 , A61K38/00
摘要： Therapeutic agents are capable of activating (GPR)124/RECK/Frizzled/lipoprotein receptor-related protein (LRP)-mediated Wnt signaling. The agents do not activate Frizzled/LRP-mediated Wnt signaling in the absence of RECK and/or GPR124. The agents are particularly useful for the prevention or treatment of neurovascular disorders or central nervous system (CNS) disorders that include neurovascular dysfunction.
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公开(公告)号：US20230367176A1
公开(公告)日：2023-11-16
申请号：US18030606
申请日：2021-10-08
发明人： Stéphane CLEMMEN , Serge MASSAR
CPC分类号： G02F1/3507 , G01J3/28 , G02F1/3526 , G02F1/353
摘要： A quasi-deterministic single-photon source and method of generating single photons on demand are disclosed. The single-photon source includes photon pair generation for generating a heralding and heralded photon in a frequency-correlated photon pair, a single-photon spectrometer adapted to detect the heralding photon and to generate an output signal that is indicative of the frequency of the detected heralding photon, a pulse shaper arrangement for reshaping a broadband pulse, and an optical frequency conversion means for converting, upon irradiation with a reshaped pulse, a heralded photon into a single output photon with deterministic source frequency. The pulse shaper arrangement is configured to select, based on the spectrometer output signal, only frequency components of the broadband pulse that substantially coincide with the heralding photon frequency or with a constant detuning thereof.
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10.发明公开公开(公告)号：US20230355534A1
公开(公告)日：2023-11-09
申请号：US18246005
申请日：2021-09-23
发明人： Youen VITRY , Jean SEPTAVAUX , Adrien DEWANDRE , Benoit SCHEID
CPC分类号： A61K9/5026 , A61K9/5089 , A61K9/5015 , A61K38/42 , B01J13/18
摘要： A method for encapsulating a compound of interest in a matrix may include preparing a first aqueous solution including the compound of interest and a gelating agent. An oil or oil mixture and a second aqueous solution having a gelation inducing agent are prepared. The first aqueous solution is emulsified in the oil or oil mixture to form an emulsion of aqueous solution droplets in oil. That emulsion is emulsified in the second aqueous solution. The gelation inducing agent from the second aqueous solution is diffused through the oil towards the interface of the oil and the first aqueous solution. Gelation of the gelating agent at the interface forms the matrix, wherein particles are obtained including the matrix composed of the gelified gelating agent and encapsulating the compound of interest.
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