公开(公告)号：US07510681B2

公开(公告)日：2009-03-31

申请号：US10695550

申请日：2003-10-28

申请人： Michael James Justin ,  James Clement Bishop ,  Stanley Michael Philipak ,  Mark Joseph Fanning

发明人： Michael James Justin ,  James Clement Bishop ,  Stanley Michael Philipak ,  Mark Joseph Fanning

IPC分类号： G01N21/13

CPC分类号： G01N21/13 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/0465 ,  G01N2035/0491 ,  Y10T436/11 ,  Y10T436/113332

摘要： A transport system is provided for a sample testing machine. The transport system includes a carrier holding a set of test sample devices and a drive subsystem for moving the carrier through the sample testing machine. The drive subsystem includes a reciprocating motor-driven block engaging the carrier and moving the carrier back and forth in a predetermined longitudinal path extending along a longitudinal axis from an entrance station to a plurality of processing stations in the sample testing machine. The processing stations are accessed as the carrier is moved along the path. The carrier includes features in the form of slots that are detected by strategically placed optical interrupt sensors. As the carrier moves, the slots are detected by the sensors to thereby continuously track the position of the carrier and the test devices as they are moved through the instrument.

摘要翻译： 为样品测试机提供运输系统。 运输系统包括一个承载一组测试样品装置的托架和用于使载体移动通过样品测试机的驱动子系统。 驱动子系统包括一个往复运动的马达驱动的块，其与载体相接合，并以沿着纵向轴线从入口站到样品测试机中的多个处理站的预定纵向路径来回移动载体。 当载体沿着路径移动时，处理站被访问。 载体包括通过策略放置的光中断传感器检测到的槽形式的特征。 当载体移动时，通过传感器检测槽，从而在载体和测试装置移动通过仪器时连续跟踪载体和测试装置的位置。

公开(公告)号：US08709344B2

公开(公告)日：2014-04-29

申请号：US12800446

申请日：2010-05-14

申请人： James C. Bishop ,  Lawrence Guerra ,  Ronnie J. Robinson ,  Mark J. Fanning ,  David M. Robbins ,  Tomasz Taubert ,  Christopher D. Justice

发明人： James C. Bishop ,  Lawrence Guerra ,  Ronnie J. Robinson ,  Mark J. Fanning ,  David M. Robbins ,  Tomasz Taubert ,  Christopher D. Justice

IPC分类号： B01F11/00

CPC分类号： C12Q1/04 ,  C12M41/36 ,  C12Q1/02 ,  G01N35/00603 ,  G01N35/0099 ,  G01N35/026 ,  G01N2035/00148 ,  G01N2035/0406 ,  G01N2035/0453 ,  G01N2035/0465

摘要： A system is disclosed for agitating multiple specimen containers each containing a sample and a growth medium. The system includes a plurality of racks. The racks have a plurality of receptacles, each of which is adapted for holding a specimen container. The racks include a first rack oriented in a first direction and a second rack oriented in a second direction different from the first direction. The system also includes a rotating turret having a frame holding the racks. The frame is rotatable about an axis, wherein the rotating turret operates to rotate the racks about the axis to an access position, e.g., where a user may access the specimen containers. The system also includes an agitation assembly coupled to the racks. The agitation assembly rocks the racks back and forth thereby agitating specimen containers held by the racks. In one configuration, the system is incorporated into an automated instrument detecting whether a microbiological agent is present in the specimen container. In another configuration, the system is incorporated into an automated instrument identifying or characterizing the microbiological agent.

摘要翻译： 公开了一种用于搅拌每个含有样品和生长培养基的多个标本容器的系统。 该系统包括多个机架。 机架具有多个插座，每个插座适于容纳标本容器。 机架包括沿第一方向定向的第一机架和沿与第一方向不同的第二方向定向的第二机架。 该系统还包括具有保持机架的框架的旋转转台。 框架可围绕轴线旋转，其中旋转转盘操作以使机架围绕轴线旋转至访问位置，例如用户可以访问标本容器的位置。 该系统还包括耦合到机架的搅拌组件。 搅拌组件来回摇摆机架，从而搅拌由机架保持的样品容器。 在一种配置中，将系统并入自动化仪器中，检测微生物剂是否存在于样品容器中。 在另一种配置中，将该系统结合到识别或表征微生物剂的自动化仪器中。

公开(公告)号：US08748122B2

公开(公告)日：2014-06-10

申请号：US12653527

申请日：2009-12-15

申请人： Jones Hyman ,  John Walsh ,  Thurman Thorpe

发明人： Jones Hyman ,  John Walsh ,  Thurman Thorpe

IPC分类号： C12Q1/04

CPC分类号： C12Q1/04

摘要： The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms.

公开(公告)号：US08647835B2

公开(公告)日：2014-02-11

申请号：US13117976

申请日：2011-05-27

申请人： John Walsh ,  Jones Hyman

发明人： John Walsh ,  Jones Hyman

IPC分类号： C12Q1/04

CPC分类号： C12Q1/04 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/3581 ,  G01N21/47 ,  G01N21/64 ,  G01N21/6486 ,  G01N21/65 ,  G01N2015/1402

摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The method may also be useful for the physical separation and/or enrichment of two or more different or individual microorganism species contained in a mixed test sample. The invention further provides for spectroscopic interrogation of the separated microorganism sample(s) to produce measurements of the microorganism and characterizing and/or identifying the microorganism(s) in the sample using said spectroscopic measurements.

摘要翻译： 本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。 本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的任选裂解步骤，随后是随后的分离步骤。 该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。 该方法还可用于混合测试样品中包含的两种或多种不同或单独的微生物物质的物理分离和/或富集。 本发明进一步提供分离的微生物样品的光谱询问以产生微生物的测量，并使用所述光谱测量来表征和/或鉴定样品中的微生物。