公开(公告)号：US11491145B2

公开(公告)日：2022-11-08

申请号：US16625343

申请日：2018-06-19

申请人： MADRIGAL PHARMACEUTICALS, INC.

发明人： Weiwen Ying ,  Dinesh U. Chimmanamada ,  David Proia

IPC分类号： A61K31/4375 ,  A61K31/502 ,  A61K31/5025 ,  A61K9/00

摘要： The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

公开(公告)号：US11160871B2

公开(公告)日：2021-11-02

申请号：US15770513

申请日：2016-10-28

申请人： TARVEDA THERAPEUTICS, INC.

发明人： Richard Wooster ,  Kerry Whalen ,  Patrick Rosaire Bazinet ,  Mark T. Bilodeau ,  Sudhakar Kadiyala ,  Samantha Perino ,  Beata Sweryda-Krawiec ,  Rajesh R. Shinde

IPC分类号： A61P35/00 ,  A61K51/08 ,  A61K47/64 ,  C07K14/72 ,  A61K47/69 ,  A61K31/404 ,  A61K31/436 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5365 ,  A61K31/655 ,  A61K31/7048 ,  A61K45/06

摘要： Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

公开(公告)号：US10954287B2

公开(公告)日：2021-03-23

申请号：US16093762

申请日：2017-04-14

申请人： Ra Pharmaceuticals, Inc.

发明人： Kristopher Josephson ,  Zhong Ma ,  Yili Sun ,  Nathan Ezekiel Nims ,  Kathleen Seyb ,  Sylvia Tobe ,  Ping Ye ,  Douangsone D. Vadysirisack ,  Guo-Qing Tang ,  Douglas A. Treco

IPC分类号： A61K38/00 ,  C07K14/82 ,  C07K7/08 ,  G01N33/574 ,  A61K47/65 ,  A61K47/64 ,  A61P35/00 ,  A61K47/14 ,  C07K7/54

摘要： The present invention provides Ras modulators including inhibitors and/or antagonists of Ras, Ras binding, and Ras-dependent cell signaling activity. Also provided are methods of utilizing the Ras modulators as therapeutics.

公开(公告)号：US10901239B2

公开(公告)日：2021-01-26

申请号：US15920414

申请日：2018-03-13

申请人： PILESTONE, INC.

发明人： Tiangang Zhuang ,  Shangzi Zou ,  Ximin Yin

IPC分类号： G02C7/10 ,  C09D7/61 ,  C09D7/41

摘要： The present invention relates to optical devices for use by color blindness viewers and more particularly, to eyeglasses which improve the ability of a color blindness viewer to discriminate between different colored objects.

公开(公告)号：US10774331B2

公开(公告)日：2020-09-15

申请号：US15837377

申请日：2017-12-11

申请人： MiNA THERAPEUTICS LIMITED

发明人： Pål Sætrom

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12N15/11 ,  C12Q1/68

摘要： The present invention provides a method of inducing insulin production in a cell by up-regulating a target gene involved in insulin production in said cell using an saRNA (short activating ribonucleic acid) which specifically targets a target antisense RNA transcript present in said cell.

公开(公告)号：US10729753B2

公开(公告)日：2020-08-04

申请号：US16243295

申请日：2019-01-09

申请人： The Regents of the University of Colorado, a Body Corporate

发明人： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC分类号： A61K38/51 ,  A61K31/385 ,  A61K31/198 ,  A61K47/60 ,  C12N9/96 ,  C12N9/88 ,  A61K45/06 ,  A61K9/00 ,  A61K31/205

摘要： Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US10466246B2

公开(公告)日：2019-11-05

申请号：US15569808

申请日：2016-04-26

申请人： DOTS Technology Corp.

发明人： Adi Gilboa-Geffen

IPC分类号： G01N33/58 ,  G01N33/68 ,  A61K38/00 ,  C12M1/34 ,  G01N33/53 ,  G01N33/542 ,  A61P37/00

摘要： The present invention is drawn to nucleic acid aptamer based signaling polynucleotides (SPNs) for allergen detection in samples. Disclosed herein include compositions, compounds, assays and methods of using said SPNs to detect one or more allergens in a sample, particularly food allergens in a food product.

公开(公告)号：US10322137B2

公开(公告)日：2019-06-18

申请号：US15711041

申请日：2017-09-21

申请人： PLACON THERAPEUTICS, INC.

发明人： Mark T. Bilodeau ,  Benoit Moreau ,  Adam H. Brockman ,  Kristan Meetze ,  Kerry Whalen ,  Richard Wooster ,  Rossitza G. Alargova

IPC分类号： C07F15/00 ,  A61K31/555 ,  A61K31/282 ,  A61K33/24

摘要： The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.

公开(公告)号：US10160962B2

公开(公告)日：2018-12-25

申请号：US14970814

申请日：2015-12-16

申请人： The Regents of the University of Colorado, a Body Corporate

发明人： Richard Carrillo ,  Jan P. Kraus ,  Tomas Majtan ,  David Naveh

IPC分类号： C12N9/88 ,  A61K38/51 ,  B01D15/36 ,  B01D15/38

摘要： This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.

公开(公告)号：US09745579B2

公开(公告)日：2017-08-29

申请号：US15013866

申请日：2016-02-02

申请人： MINA THERAPEUTICS LIMITED

发明人： Pål Sætrom

IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61K31/713 ,  A61K31/7105 ,  C12N15/11 ,  C12N5/00

CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/113 ,  Y02A90/26

摘要： The present invention provides short activating RNA molecules which up-regulate albumin production. The present invention also provides methods of up-regulating albumin production, such methods involving the use of short activating RNA molecules capable of increasing the expression of albumin. The present invention also provides the use of the short activating RNA molecules in therapy, such as treating or preventing a hyperproliferative disorder and/or a disorder characterised by hypoalbuminemia.