公开(公告)号：US11505550B2

公开(公告)日：2022-11-22

申请号：US17164428

申请日：2021-02-01

申请人： HORIZON ORPHAN LLC

发明人： Todd C. Zankel ,  John Unitt ,  Timothy Phillips ,  Benoit Gourdet ,  Lorna Duffy

IPC分类号： C07C323/30 ,  C07D211/54 ,  C07C323/26 ,  C07D211/60 ,  C07D471/08 ,  A61K31/145 ,  A61K31/4402 ,  A61K31/4465 ,  A61K31/40 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/397 ,  C07C323/25 ,  C07D205/04 ,  C07D207/08 ,  C07D213/32 ,  C07D213/70 ,  C07D223/06 ,  C07D295/088 ,  C07D451/04

摘要： The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.

公开(公告)号：US11310485B2

公开(公告)日：2022-04-19

申请号：US17122848

申请日：2020-12-15

申请人： Washington University

发明人： Samuel Achilefu ,  Yang Liu ,  Viktor Gruev ,  Joseph P. Culver ,  Walter Akers ,  Adam Bauer

IPC分类号： G09G5/00 ,  H04N13/344 ,  A61B90/00 ,  A61B90/30 ,  A61B34/00 ,  A61K49/00 ,  C07K7/06 ,  G02B27/01 ,  H04N5/374 ,  A61B1/00 ,  A61B1/06

摘要： A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.

公开(公告)号：US11160814B1

公开(公告)日：2021-11-02

申请号：US17194931

申请日：2021-03-08

申请人： Ensemble Group Holdings

发明人： Michael David Kuo

IPC分类号： A61K31/58 ,  A61K31/167 ,  A61K31/567 ,  A61K31/137 ,  A61P11/16 ,  A61K31/40 ,  A61K31/4704 ,  A61K31/381 ,  A61K31/522 ,  A61K45/06 ,  A61K31/439 ,  A61K31/404

摘要： Disclosed herein are methods of treating a disease in a subject which is the consequence of previous exposure of the subject to a virus, particularly SARS-CoV-2, the method comprising administration of an effective amount of one or more agents to the subject.

公开(公告)号：US10975069B2

公开(公告)日：2021-04-13

申请号：US16426791

申请日：2019-05-30

申请人： Washington University

发明人： William Hawkins ,  Robert Mach ,  Dirk Spitzer ,  Suwanna Vangveravong ,  Brian Van Tine

IPC分类号： C07D451/14 ,  A61K31/517 ,  A61P35/00 ,  C07D471/08 ,  A61K31/496 ,  A61K45/06

摘要： Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described, such as the methanesulfonate salt of a compound of structural Formula IV, , wherein n is an integer chosen from 1, 2, 3, 4, and 5, and R2 is H or methyl. At least one described molecular species exhibits an IC50 value below 5 μM against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo. It led to a 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.

公开(公告)号：US10369144B2

公开(公告)日：2019-08-06

申请号：US16289165

申请日：2019-02-28

申请人： PureTech Health LLC

发明人： Eric Elenko ,  Philip E. Murray, III ,  Andrew C. Miller

IPC分类号： A61K31/46 ,  A61K9/48 ,  A61K31/4439 ,  A61K31/222 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4725 ,  A61K45/06 ,  A61K31/138

摘要： The present disclosure provides a method of treating a central nervous system disorder in a patient in need thereof. The method comprises orally administering between 75 mg and 300 mg xanomeline and between 20 mg and 200 mg trospium chloride to the patient during a 24-hour period. The central nervous system disorder is selected from schizophrenia, Alzheimer's disease, Huntington's disease, Parkinson's disease, and Lewy Body dementia, wherein use of the trospium chloride alleviates a side effect associated with use of the xanomeline.

公开(公告)号：US10301507B2

公开(公告)日：2019-05-28

申请号：US16165557

申请日：2018-10-19

申请人： Burning Bush Group, LLC

发明人： Chris Fish ,  Jerry Kilby

IPC分类号： C09D183/16 ,  B05D3/02 ,  C08G77/60 ,  C08G77/62

摘要： Provided herein is a method of coating a surface. A silicon-based coating composition is coated onto a surface. The composition comprises 5% to 80% polysilazane, 20% to 60% polysiloxane, and polysilane of a formula (R1R2Si)n, wherein n is greater than 1, and wherein R1 and R2 are the same or different and are chosen from alkyl, alkenyl, cycloalkyl, alkylamino, aryl, aralkyl, or alkylsilyl, which polysilane has a weight average molecular weight of more than 50,000, and optionally organic solvent. The coating is cured ambiently to provide a non-ceramic clear coating having a thickness ranging between 0.1 mil and 1.5 mil, a hardness ranging between 2H and 9H in accordance with ASTM 3363 for film hardness by pencil test, and a kinetic coefficient of friction between 0.03 and 0.04. Also provided are silicon-based coating compositions and cured coatings from those compositions using the provided method.

公开(公告)号：US10138381B2

公开(公告)日：2018-11-27

申请号：US13891438

申请日：2013-05-10

申请人： Burning Bush Group, LLC

发明人： Chris Fish

IPC分类号： C09D5/18 ,  C09D183/14 ,  C08G77/54 ,  C08G77/04

摘要： A silicon based coating composition for a wide range of surfaces, which composition is formed from a mixture of constituents comprising appropriate portions of silazane, siloxane, and silane, and optionally organic solvent and additives, and the composition results in a coating having a thickness between 0.4 mil and 1.5 mil, a hardness of 4-9H and an endurance to continuous temperature above 1600° F.

公开(公告)号：US11015083B2

公开(公告)日：2021-05-25

申请号：US16844513

申请日：2020-04-09

申请人： Burning Bush Group, LLC

发明人： Chris Fish ,  Jerry Kilby

IPC分类号： C09D183/16 ,  B05D3/02 ,  C08G77/60 ,  C08G77/62

摘要： Provided herein is a method of coating a surface. A silicon-based coating composition is coated onto a surface. The silicon-based coating composition comprises polysilazane and polysilane comprising a formula (R1R2Si)n, wherein n is greater than 1, and wherein R1 and R2 are the same or different and are chosen from alkyl, alkenyl, cycloalkyl, alkylamino, aryl, aralkyl, or alkylsilyl, which polysilane has a weight average molecular weight of more than 50,000. Also provided are silicon-based coating compositions and cured coatings from those compositions using the provided method.

公开(公告)号：US10538685B2

公开(公告)日：2020-01-21

申请号：US15600084

申请日：2017-05-19

申请人： Techneglas LLC

发明人： Christopher Fish

IPC分类号： C09D183/04 ,  C08L83/04 ,  B29C70/46 ,  B29C70/34 ,  C09D183/16 ,  C08K3/04 ,  C08K3/38 ,  C08L83/00 ,  C08L83/16 ,  B29K83/00 ,  B29K105/12 ,  C08G77/62

摘要： Provided herein is a composition comprising from 50% to 60% polysiloxane consisting essentially of polyphenylmethylsiloxane and α,ω-methoxy-terminated polydimethylsiloxane, from 40% to 50% organic solvent, from 2% to 4% polysilazane, and polysilane of a formula (R1R2Si)n, wherein n is greater than 1, and wherein R1 and R2 are the same or different and are alkyl, alkenyl, cycloalkyl, alkylamino, aryl, aralkyl, or alkylsilyl. The composition, after curing, is a flame resistant binder for forming a composition-fiber composite that withstands repeated temperatures over 1800° F. The composition may further comprise from 0.1% to 2% of an enhancer selected from butyltitanate and aminoethylaminopropyltrimethoxysilane (H2NC2H4NHC3H6—Si(OCH3)3). The composition may be mixed with fibers in a ratio of 35:65 to 45:55 (w/w), and the composition-fiber mixture may be cured under vacuum at a temperature of 200° F. to 450° F. for 30 minutes to 180 minutes to form a composite.

公开(公告)号：US10344029B2

公开(公告)日：2019-07-09

申请号：US16111842

申请日：2018-08-24

申请人： Washington University

发明人： William Hawkins ,  Robert Mach ,  Dirk Spitzer ,  Suwanna Vangveravong ,  Brian Van Tine

IPC分类号： C07D451/14 ,  C07D471/08 ,  A61K31/496 ,  A61K31/517 ,  A61K45/06

摘要： The present disclosure provides compounds of structural Formula III: or a salt thereof, wherein Y is chosen from Further provided are pharmaceutical compositions comprising these compounds, and methods for treating cancer, such as pancreatic cancer or synovial sarcoma, using the compounds and compositions.