公开(公告)号：US12131803B2

公开(公告)日：2024-10-29

申请号：US16757329

申请日：2018-10-17

申请人： THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Giulio Genovese ,  Po-Ru Loh ,  Steven McCarroll

IPC分类号： G16B20/10 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B5/00 ,  G16B20/20 ,  G16H10/40

CPC分类号： G16B20/10 ,  G16B5/00 ,  G16B20/20 ,  G16H10/40 ,  C12Q1/6883 ,  C12Q1/6886

摘要： Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.

公开(公告)号：US12089765B2

公开(公告)日：2024-09-17

申请号：US17031274

申请日：2020-09-24

申请人： Philip DiTrolio

发明人： Philip DiTrolio

IPC分类号： A47H1/142 ,  E04H1/12

CPC分类号： A47H1/142 ,  E04H1/1272

摘要： The present coupler-mounted connector enables industry standard hooks on horizontal rods to rest at such a height as to provide uniform appearance to the top of drape walls. The coupler-mounted connector includes an adaptor to support couplers for the drape rods to be mounted on a vertically disposed, affixed coupler, such as a coupler on a pipe, a flat-mounted coupler, or any other coupler. The body of the coupler-mounted connector is positioned around the affixed coupler. The coupler-mounted connector includes a spanning element with a lower wedge to mate with the openings in the upper body of the affixed coupler. The coupler-mounted connector is secured in the coupler with the accessories protruding to one or more sides of the coupler-mounted connector. The accessories are connected to the coupler-mounted connector by one or more connection bridges.

公开(公告)号：US12046151B2

公开(公告)日：2024-07-23

申请号：US17100149

申请日：2020-11-20

申请人： Edward Via College of Osteopathic Medicine

发明人： Jeremy Jason White

IPC分类号： G09B23/30 ,  G09B23/28

CPC分类号： G09B23/30 ,  G09B23/285

摘要： Described and demonstrated herein are embodiments of a self-supporting wearable device that can be used for medical training and simulations. Also described herein are methods of using the wearable device described herein.

公开(公告)号：US12041945B2

公开(公告)日：2024-07-23

申请号：US18516686

申请日：2023-11-21

申请人： WTI, INC.

发明人： Wolf Peter Ludwig

IPC分类号： A23L27/24 ,  A23B4/027 ,  A23B4/12 ,  A23B4/20 ,  A23B4/24 ,  A23L3/3472 ,  A23L3/3508 ,  A23L27/00 ,  A23P10/40

CPC分类号： A23B4/027 ,  A23B4/12 ,  A23B4/20 ,  A23B4/24 ,  A23L3/3472 ,  A23L3/3508 ,  A23L27/24 ,  A23L27/82 ,  A23P10/40 ,  A23V2002/00 ,  Y02A40/90

摘要： A method of processing is disclosed that provides improved water retention and enhanced coloring and flavor, while preserving the meat and preventing bacterial contamination. In an exemplary embodiment, the method includes: (a) providing a body of meat at a first temperature; (b) contacting the body of meat of step (a), in at least one treating vessel, with a brine solution at a second temperature, wherein the second temperature is greater than the first temperature, and wherein the brine solution comprises a vinegar-derived food additive and/or a reddening agent, wherein the reddening agent comprises nitrite; (c) agitating the body of meat at the second temperature for a time sufficient to distribute the solution throughout the body of meat; (d) cooling the body of meat in at least one cooling vessel to a third temperature, wherein the third temperature is less than the second temperature; (e) agitating the body of meat at the third temperature; (f) contacting the body of meat of step (e) with the brine solution at the third temperature and agitating the body of meat at the third temperature until the brine solution is substantially absorbed by the body of meat; and (g) recovering the body of meat in a dry state at the third temperature.
In one embodiment, the aforementioned brine solution comprises a vinegar-variety food additive, such as a vinegar-derived acetate composition. In another embodiment, the reddening agent comprises nitrate derived from plant material comprising nitrate.

公开(公告)号：US11963966B2

公开(公告)日：2024-04-23

申请号：US16499393

申请日：2018-03-30

申请人： Dana-Farber Cancer Institute, Inc. ,  The Broad Institute, Inc. ,  Massachusetts Institute of Technology

发明人： Levi Garraway ,  Benjamin Izar ,  Aviv Regev ,  Orit Rozenblatt-Rosen ,  Asaf Rotem ,  Elizabeth Stover ,  Itay Tirosh

IPC分类号： A61K31/575 ,  A61K9/00 ,  A61K33/243 ,  A61K35/17 ,  A61K39/395

CPC分类号： A61K31/575 ,  A61K9/0019 ,  A61K33/243 ,  A61K35/17 ,  A61K39/39533

摘要： Described herein are compositions and methods of using single-cell RNA-sequencing to identify treatment resistance in patients with ovarian cancer. Also, described herein are compositions and methods for treatment targeting resistance in patients with ovarian cancer.

公开(公告)号：US11943215B1

公开(公告)日：2024-03-26

申请号：US17334186

申请日：2021-05-28

申请人： CITIGROUP TECHNOLOGY, INC.

发明人： Sandeep Nair ,  Matthew E. Nunn ,  Julio Caraballo ,  Jason Edward Morris ,  Udaya Chandupatia ,  Partha S. Peddi

IPC分类号： H04L9/40 ,  G06F8/65 ,  H04L9/32

CPC分类号： H04L63/083 ,  G06F8/65 ,  H04L9/3226 ,  H04L9/3268 ,  H04L63/0823 ,  H04L63/0869

摘要： Machines, devices, and other objects are configured to use authorization tokens to verify object identities without human input. In examples, the object uses a password to validate the object's identity to an authorization server to obtain an access token for use in multiple applications. In another example, the object uses a certificate to validate the object's identity to an authorization server to obtain an access token. In other examples, any other suitable identifying data may be used to validate the object's identity to an authorization server to obtain an access token. The process of using passwords, certificates, or other validation processes to obtain tokens or other authorization mechanisms allows the object to authenticate themselves without human interaction and to use a single identity to access services from multiple service providers that trust a central authorization server.

公开(公告)号：US11943096B1

公开(公告)日：2024-03-26

申请号：US18376051

申请日：2023-10-03

申请人： CITIBANK, N.A.

发明人： Raja Balasubramanian ,  Rene Wilfredo Villatoro Escalante ,  Chike Gideon Okechukwu ,  Terry John Jenkins ,  Scott Taylor

IPC分类号： H04B10/03 ,  H04B10/079 ,  H04L41/069 ,  H04L41/22

CPC分类号： H04L41/069 ,  H04B10/03 ,  H04B10/07955 ,  H04L41/22

摘要： The technology may be utilized in network environments that use fiber optic cables to connect components. Components of the network perform functions as transceivers that transmit and receive light signals via the fiber cable. When optic power data received from the transceivers is recognized as a fault, an event is identified. The system logs each received event and converts all measurements into a common unit of measurement. The system analyzes aggregated data from the transceivers to detect patterns and trends, monitor the received data and provide real time fault predictions. For example, a machine learning process may recognize subtle trends or patterns in the data, and use the recognition to predict potential failures. The system uses the received data to create a graphical user interface (“GUI”) that represents the health of the network.

公开(公告)号：US11882400B2

公开(公告)日：2024-01-23

申请号：US17623309

申请日：2020-06-24

申请人： NNNN AS

发明人： Rune Skramstad

IPC分类号： H04R1/30 ,  H04R1/34 ,  H04R1/02

CPC分类号： H04R1/345 ,  H04R1/02

摘要： The present invention discloses directional loudspeaker at least comprising: a loudspeaker cabinet comprising: a folded horn with a length of minimum one quarter of a wavelength, λ, and the horn mouth opening is asymmetrically placed in a front baffle providing a physical delay between the different wraparound pathways to the rear side of the loudspeaker cabinet; one or more driver speakers loading the horn with an open rear chamber, the open rear chamber having at least two opening pathways with a distance there between providing a physical delay of a rear wave, the loudspeaker cabinet provides at least four pathways for in phase and out of phase signals, at least two pathways for the out of phase signal and at least two pathways for the in phase signal amplified by the horn.

公开(公告)号：US11873483B2

公开(公告)日：2024-01-16

申请号：US15557442

申请日：2016-03-11

申请人： THE BROAD INSTITUTE, INC. ,  ÉCOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (ESPCI PARIS TECH)

发明人： Robert Nicol ,  Andrew David Griffiths ,  Baptiste Saudemont ,  Timothy V. Kirk

IPC分类号： C12P19/34 ,  C12N15/10 ,  G01N33/68 ,  C12Q1/6816

CPC分类号： C12N15/1075 ,  C12Q1/6816 ,  G01N33/6845 ,  G01N2458/10 ,  C12Q1/6816 ,  C12Q2563/159 ,  C12Q2565/514

摘要： The disclosure provides methods and compositions useful for labeling of target molecules with origin-specific nucleic acid identifiers (for example, barcodes), which can be used subsequently to identify, quantify, or otherwise characterize a feature or activity of target molecules originating from a particular discreet volume. Such target molecules can include polypeptides expressed by cells, in which nucleic acid molecules encoding the polypeptides are labeled with the same, or matched, origin-specific nucleic acid identifiers.

公开(公告)号：US11844800B2

公开(公告)日：2023-12-19

申请号：US17085650

申请日：2020-10-30

申请人： Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc.

发明人： Alexander K. Shalek ,  Peter Winter ,  David Weinstock ,  Mark Murakami ,  Scott Manalis ,  Andrew Navia ,  Jennyfer Galvez-Reyes

IPC分类号： A61K31/506 ,  C07K16/28 ,  A61K45/06 ,  A61K31/403 ,  A61K31/427 ,  A61K31/5383 ,  A61K31/44 ,  A61P35/02

CPC分类号： A61K31/506 ,  A61K31/403 ,  A61K31/427 ,  A61K31/44 ,  A61K31/5383 ,  A61K45/06 ,  A61P35/02 ,  C07K16/2887

摘要： Described in exemplary embodiments herein are methods, compositions, and kits for diagnosing, prognosing, monitoring, treating and/or preventing a hemopoietic malignancy and/or relapse thereof in a subject. In some embodiments, the methods can include determining an average cellular mass of cells in a sample from the subject and/or detecting one or more molecular signatures in one or more of the cells. In some embodiments, treatment includes administering one or more BCR-ABL tyrosine kinase inhibitors or a pharmaceutical formulation thereof, one or more pre-BCR signaling pathway inhibitors or a pharmaceutical formulation thereof, one or more p38 MAPK inhibitors or a pharmaceutical formulation thereof; or any combination thereof.