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公开(公告)号：US10478295B2
公开(公告)日：2019-11-19
申请号：US15918987
申请日：2018-03-12
发明人： Richard George Cartledge , Kevin W. Smith , Thomas O. Bales, Jr. , Max Pierre Mendez , Korey Kline , Matthew A. Palmer , Michael Walter Kirk , Carlos Rivera , Derek Dee Deville
摘要： A delivery apparatus can include a handle portion and at least one rotatable drive shaft. The handle portion can have an actuation mechanism with a motor. The rotatable drive shaft can have a proximal end portion and a distal end portion. The proximal end portion of the rotatable drive shaft can be coupled to the motor, and the distal end portion of the rotatable drive shaft can be configured to be releasably coupled to a prosthetic heart valve. The actuation mechanism can be configured to control and monitor expansion of the prosthetic heart valve and to control and monitor torque of the motor.
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公开(公告)号：US10463484B2
公开(公告)日：2019-11-05
申请号：US15808599
申请日：2017-11-09
发明人： Tamir S. Levi
摘要： Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve can include an annular frame having an inflow end, an outflow end and a central longitudinal axis extending from the inflow end to the outflow end. The valve can include a valvular structure including two or more leaflets, each of the two or more leaflets having a leaflet inflow edge positioned at least partially outside of the frame and a leaflet outflow edge positioned within the frame, wherein at least a portion of each of the leaflet inflow edges is unsupported by the frame.
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公开(公告)号：US10426611B2
公开(公告)日：2019-10-01
申请号：US16202980
申请日：2018-11-28
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh A. Khanna , Son V. Nguyen , Tamir S. Levi , Itai Pelled
摘要： A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.
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公开(公告)号：US10413406B2
公开(公告)日：2019-09-17
申请号：US16201625
申请日：2018-11-27
发明人： Netanel Benichou
IPC分类号： A61F2/24
摘要： An implantable prosthetic valve has an upper frame section and a lower frame section. The upper frame section has a plurality of struts and a first leaflet receiving surface at a lower portion of the upper frame section. The lower frame section has a second leaflet receiving surface at an upper portion of the lower frame section. An edge of a flexible leaflet is disposed between the first and second leaflet receiving surfaces to attach the leaflet to the upper and lower frame sections.
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公开(公告)号：US10327897B2
公开(公告)日：2019-06-25
申请号：US15085842
申请日：2016-03-30
发明人： Gilbert Madrid , Matthew T. Winston , Sam Sok , Thanh Huy Le , Tri D. Tran , Kim Le , Michael D. Franklin
摘要： A delivery system for stabilizing a catheter shaft across an aortic arch can include one or more stabilizing members configured to fix or stabilize the position of the catheter relative to the aortic arch of a patient.
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公开(公告)号：US10299923B2
公开(公告)日：2019-05-28
申请号：US16202980
申请日：2018-11-28
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh A. Khanna , Son V. Nguyen , Tamir S. Levi , Itai Pelled
摘要： A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.
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公开(公告)号：US10238514B2
公开(公告)日：2019-03-26
申请号：US15793867
申请日：2017-10-25
发明人： Richard Cartledge , Kevin W. Smith , Thomas O. Bales, Jr. , Derek Dee Deville , Korey Kline , Max Pierre Mendez , Matthew A. Palmer , Michael Walter Kirk , Carlos Rivera , Eric Petersen , Sean McBrayer
摘要： A delivery apparatus comprises a handle portion and at least one rotatable drive shaft. The handle portion has an actuation mechanism and a display. The actuation mechanism includes a motor and one or more actuators. The rotatable drive shaft has a proximal end portion and a distal end portion. The proximal end portion is coupled to the motor, and the distal end portion is configured to be releasably coupled to a prosthetic heart valve. The actuation mechanism is configured to control and monitor expansion of the prosthetic heart valve, and the display is configured to display a diameter of the prosthetic heart valve.
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公开(公告)号：US10154904B2
公开(公告)日：2018-12-18
申请号：US14695607
申请日：2015-04-24
发明人： Brian C. Gray , Tung T. Le , Andrew Oien , Sonny Tran , Thanh Huy Le , Robert Bowes , Maria L. Saravia , Uy D. Trinh , Hamid Rafi , Alejandro J. Froimovich Rosenberg
摘要： Disclosed embodiments of introducer devices provide hemostatic sealing and allow a delivery catheter to be inserted through the introducer seals without the use of a separate loader device that covers a medical device that is mounted on the catheter. Some disclosed introducers comprise a housing, a distal sheath extending distally from the housing and adapted to be inserted into a patient's vasculature, a distal hemostatic seal mounted within the housing and a proximal hemostatic seal mounted within the housing, and a slidable tube positioned within the housing that is movable longitudinally relative to the distal hemostatic seal between a proximal position and a distal position, wherein in the proximal position a distal end of the tube is positioned proximal to the distal hemostatic seal with the distal hemostatic seal closed, and wherein in the distal position the distal end of the tube extends through the distal hemostatic seal.
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公开(公告)号：US07563943B2
公开(公告)日：2009-07-21
申请号：US11956228
申请日：2007-12-13
CPC分类号： C12N15/8246 , A23K10/30 , A23K20/147 , A23K20/158 , A23K20/163 , A23L25/30 , A23L33/185 , C07K14/415 , C12N15/8247 , C12N15/8251
摘要： The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an HIO nucleic acid. The invention is further directed to methods of generating plants with an improved oil quantity phenotype or improved meal quality phenotype.
摘要翻译： 本发明涉及由于HIO核酸的表达改变而显示改善的油量表型或改善的膳食质量表型的植物。 本发明进一步涉及产生具有改善的油量表型或改良的膳食质量表型的植物的方法。
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公开(公告)号：US07285350B2
公开(公告)日：2007-10-23
申请号：US10671750
申请日：2003-09-26
CPC分类号： H01M8/04007 , H01M8/0637 , H01M8/1231 , H01M8/2428 , H01M8/243 , H01M8/244 , Y02E60/566
摘要： Enhanced high temperature fuel cell systems, such as solid oxide fuel cell systems and molten carbonate fuel cell systems are disclosed. Embodiments of the disclosure include solid oxide and molten carbonate fuel cell systems incorporating gas separation apparati facilitating the recycle of hydrogen fuel from fuel cell anode exhaust for supply to the fuel cell anode inlet. Further embodiments of the disclosure include solid oxide and molten carbonate fuel cell systems incorporating inventive combinations of anode materials conducive to combination with enriched hydrogen fuel. Other embodiments of the disclosure include gas separation apparati for providing enriched oxygen feed to the cathode inlet of solid oxide and molten carbonate fuel cells.
摘要翻译： 公开了增强的高温燃料电池系统，例如固体氧化物燃料电池系统和熔融碳酸盐燃料电池系统。 本公开的实施方案包括固体氧化物和熔融碳酸盐燃料电池系统，其包括气体分离装置，其有助于将燃料电池阳极排气中的氢燃料循环供应到燃料电池阳极入口。 本公开的另外的实施方案包括固体氧化物和熔融碳酸盐燃料电池系统，其结合有助于与富集氢燃料组合的阳极材料的本发明组合。 本公开的其它实施方案包括气体分离装置，用于向固体氧化物和熔融碳酸盐燃料电池的阴极入口提供富集的氧气进料。
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