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6 条记录 (耗时 0.012 秒)

    Method for detection of high risk human papillomavirus
    1.
    发明授权
    Method for detection of high risk human papillomavirus 有权
    高危人乳头状瘤病毒检测方法

    公开(公告)号：US09453265B2

    公开(公告)日：2016-09-27

    申请号：US14172793

    申请日：2014-02-04

    申请人： Trovagene, Inc.

    发明人： Samuil R. Umansky ,  Hovsep S. Melkonyan ,  Zhenghan M. Xin

    IPC分类号： C12P19/34 ,  C12Q1/70

    CPC分类号： C12Q1/708 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.

    摘要翻译： 本发明提供了用于从患者提供的尿样中差异检测HPV的高风险形式的组合物和方法。 具体地说，本发明提供了特异性识别和结合HPV基因E1基因序列的引物和探针。 检测HPV的高风险形式识别患有发展或宫颈癌早期发生危险的个体。

    Athletic wear with hidden pockets
    3.
    发明授权
    Athletic wear with hidden pockets 有权
    运动服与隐藏的口袋

    公开(公告)号：US09060550B2

    公开(公告)日：2015-06-23

    申请号：US13891144

    申请日：2013-05-09

    申请人： Christina Conrad

    发明人： Christina Conrad

    IPC分类号： A41C3/00

    CPC分类号： A41C3/0035 ,  A41C3/0057 ,  A41C3/08

    摘要： An article of clothing containing concealed pockets for storing and protecting smart phones, identification cards, credit cards, and other objects is provided. In some preferred embodiments, the article of clothing is sportswear or a sports bra.

    摘要翻译： 提供了一种包含用于存储和保护智能电话，身份证，信用卡和其他物体的隐藏口袋的衣物。 在一些优选实施例中，衣物是运动服或运动胸罩。

    Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media
    4.
    发明授权
    Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media 有权
    使用阴离子交换介质从体液分离核酸的组合物，方法和试剂盒

    公开(公告)号：US09163229B2

    公开(公告)日：2015-10-20

    申请号：US11974016

    申请日：2007-10-10

    申请人： Hovsep Melkonyan ,  Erik Meyer ,  William John Feaver ,  Samuil R. Umansky

    发明人： Hovsep Melkonyan ,  Erik Meyer ,  William John Feaver ,  Samuil R. Umansky

    IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/10 ,  C12Q1/68

    CPC分类号： C12N15/101 ,  C12N15/1006 ,  C12N15/1017 ,  C12Q1/6806

    摘要： This invention provides compositions and methods for rapid isolation and purification of nucleopolymers from biological samples using anionic exchange media. The method of this invention can utilize commercially available anion exchanger materials with selected solutions of known ionic strength for absorption and elution. The medium/nucleoprotein bound complex may be optionally stored or transported, and is subsequently treated with eluents to remove undesirable proteins and inorganic salts. The partially purified complex may also be stored or transported. This method is particularly advantageous since it allows rapid isolation and purification of soluble nucleic acids from a large volume of biological fluids with easy handling and storage, stabilizing the samples against degradation prior to analysis. It also permits the purification and identification of shorter fragments of nucleic acids from bodily fluids which, until now, had not been identified. The method is widely useful to prepare samples formats that are convenient in diagnostic analytical methods.

    摘要翻译： 本发明提供了使用阴离子交换介质从生物样品快速分离和纯化核聚合物的组合物和方法。 本发明的方法可以利用具有已知离子强度的所选溶液进行吸收和洗脱的市售阴离子交换剂材料。 中等/核蛋白结合的复合物可以任选地储存或运输，随后用洗脱液处理以除去不需要的蛋白质和无机盐。 部分纯化的复合物也可以被储存或运输。 该方法是特别有利的，因为其允许从易于处理和储存的大量生物流体中快速分离和纯化可溶性核酸，从而在样品分析之前使样品不会降解。 它还允许纯化和鉴定来自身体液体的较短的核酸片段，迄今为止尚未鉴定。 该方法广泛用于准备在诊断分析方法中方便的样品格式。

    Tumor activated prodrugs
    6.
    发明授权
    Tumor activated prodrugs 有权
    肿瘤活化前药

    公开(公告)号：US08957016B2

    公开(公告)日：2015-02-17

    申请号：US13485595

    申请日：2012-05-31

    申请人： Samuel R. Denmeade ,  John T. Isaacs

    发明人： Samuel R. Denmeade ,  John T. Isaacs

    IPC分类号： A61K38/08 ,  C07K7/06 ,  A61K38/16 ,  A61K47/48

    CPC分类号： A61K38/08 ,  A61K38/168 ,  A61K47/65 ,  C07K7/06

    摘要： The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences: Ser-Ser-Lys-Tyr-Gln (SEQ ID NO:1); Gly-Lys-Ser-Gln-Tyr-Gln (SEQ ID NO:2); and Gly-Ser-Ala-Lys-Tyr-Gln (SEQ ID NO:3) wherein the peptide is linked to the therapeutically active drug to inhibit the therapeutic activity of the drug, and wherein the therapeutically active drug is cleaved from the peptide upon proteolysis by an enzyme having a proteolytic activity of prostate specific antigen (PSA). The invention further provides methods of making and using the claimed compositions.

    摘要翻译： 本发明提供包含前药的组合物，前药包含治疗活性药物; 和选自以下序列的肽：Ser-Ser-Lys-Tyr-Gln（SEQ ID NO：1）; Gly-Lys-Ser-Gln-Tyr-Gln（SEQ ID NO：2）; 和Gly-Ser-Ala-Lys-Tyr-Gln（SEQ ID NO：3），其中所述肽与治疗活性药物连接以抑制药物的治疗活性，并且其中治疗活性药物从肽切割 通过具有前列腺特异性抗原（PSA）的蛋白水解活性的酶进行蛋白水解。 本发明还提供制备和使用所要求保护的组合物的方法。