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公开(公告)号：US12131589B2
公开(公告)日：2024-10-29
申请号：US17974432
申请日：2022-10-26
申请人： IPS GROUP INC.
摘要： A meter apparatus and method of operating a removable meter apparatus are described. The meter apparatus includes a tag associated with unique tag identification information and configured to be permanently affixed to a location housing at a unique physical location, and includes a removable meter unit configured to mate with the location housing and receive the tag identification from the tag and report the tag identification to a data manager configured to associate an identifier of the removable meter unit with the tag identification and unique physical location, and associate configuration information for the physical location with the removable meter unit and the tag identification. The unique physical location can comprise a single-space parking location.
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公开(公告)号：US12129249B2
公开(公告)日：2024-10-29
申请号：US17180127
申请日：2021-02-19
发明人： Sayuri Hirano , Yoshiyuki Takeda , Koji Nakamoto , Motoki Ikeuchi , Masato Kitayama , Masatoshi Yamada , Jun-ichi Kawakami
IPC分类号： C07D417/12 , C07D417/14
CPC分类号： C07D417/14 , C07D417/12
摘要： The aim of the present invention is to provide a method capable of producing an optically active pyrimidinamide derivative on an industrial scale.
Compound (I) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, and the obtained compound (III) or a salt thereof is reacted with compound (VI) or a salt thereof to obtain compound (V) or a salt thereof.
wherein each symbol is as defined in the specification.-
公开(公告)号：US12128174B1
公开(公告)日：2024-10-29
申请号：US18604209
申请日：2024-03-13
IPC分类号： A61M15/00
CPC分类号： A61M15/0001 , A61M2205/3334 , A61M2205/3584 , A61M2205/581 , A61M2205/583 , A61M2230/40
摘要： Disclosed herein are devices and methods for the use of medicament devices. The devices and methods may be used to detect or sense one or more parameters of a medicament device, for instance, shake parameters, actuation parameters, or inhalation airflow parameters. The devices and methods may be used to indicate to a user that the medicament device is in an appropriate condition for actuation of the medicament device. The devices and methods may be used to indicate to a user that the medicament device is in a condition to deliver an intended dosage range of a formulation. The devices and methods may further be used to guide a user through proper usage of a medicament device.
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公开(公告)号：USD1048460S1
公开(公告)日：2024-10-22
申请号：US29795241
申请日：2021-06-17
设计人： Joseph Anthony , Nathan Beckett , Ryan Rosenfeld
摘要： FIG. 1 is a front perspective view of a sequencer machine, according to a new design;
FIG. 2 is a top back perspective view thereof;
FIG. 3 is a front view of thereof;
FIG. 4 is a left view of thereof;
FIG. 5 is a back view of thereof;
FIG. 6 is a right side view of thereof; and,
FIG. 7 is a top view of thereof.
FIG. 8 is a close-up view of an area of the front of the sequencer machine as indicated by a circle in FIG. 3.
FIG. 9 is a close-up view of the area of the rear of the sequencer machine as indicated by a circle in FIG. 5; and,
FIG. 10 is a close-up view of the area of the side of the sequencer machine as indicated by a circle in FIG. 6.
In the drawings, the equal-length broken lines depict portions of the sequencer machine and form no part of the claimed design. The dash-dot-dash broken lines define the limits of the enlarged portions shown. All broken lines form no part of the claim.-
公开(公告)号：US12122827B2
公开(公告)日：2024-10-22
申请号：US18307477
申请日：2023-04-26
发明人： Yik Andy Yeung , Renee L. Greer , Henry C. Nguyen , David Liu , Byong Kang , Ivana Djuretic
CPC分类号： C07K16/244 , A61P35/00 , C07K14/54 , C07K16/2815 , C07K16/40 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/64 , C07K2317/92 , C07K2319/30 , C07K2319/33 , C07K2319/74
摘要： The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.
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公开(公告)号：US12119782B2
公开(公告)日：2024-10-15
申请号：US18053687
申请日：2022-11-08
申请人： Planted Solar, Inc.
发明人： Richard Erb , Gilad Almogy , Nathan Beckett
CPC分类号： H02S30/10 , B25J9/1687 , B60P1/00 , E04H12/347 , G01L5/0033 , G05D1/0088 , H02S20/10 , H02S20/32
摘要： In an aspect, the present disclosure describes a system for constructing a solar module array. The system can comprise one or more mobile platforms; one or more carriers operatively coupled to the one or more mobile platforms, wherein the one or more carriers support a plurality of posts and/or a plurality of solar modules; one or more robotic components for retrieving one or more posts from the plurality of posts and one or more solar modules from the plurality of solar modules from the one or more carriers; and at least one controller in operative communication with the one or more mobile platforms and the one or more robotic components, wherein the at least one controller (i) directs the one or more mobile platforms to transport the one or more carriers over a terrain and (ii) controls the one or more robotic components to (1) autonomously position and install the one or more posts on the terrain, and (2) autonomously position and assemble the one or more solar module to the one or more posts installed on the terrain to thereby construct the solar module array on the terrain.
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公开(公告)号：US12119115B2
公开(公告)日：2024-10-15
申请号：US18156010
申请日：2023-01-18
发明人： Luca Foschini , Filip Jankovic , Raghunandan Melkote Kainkaryam , Juan Ignacio Oguiza Mendez , Arinbjörn Kolbeinsson
摘要： Disclosed is a method comprising accessing, by a machine learning system, a set of data records for a plurality of users, the data records representative of physical statistics measured for each of the plurality of users over a time period. At least a subset of the data records comprises patterns of missing data for at least a portion of the time period. The method also comprises generating a set of masked data records by masking a subset of the data records in accordance with a pattern of natural missingness from a data record. The method also comprises generating, by the machine learning system, a set of learned representations from at least the set of masked data records. Finally, the method comprises fine tuning, by the machine learning system, a machine learning model using the set of learned representations, the machine learning model configured to perform a downstream machine learning task.
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公开(公告)号：US12115242B2
公开(公告)日：2024-10-15
申请号：US18334287
申请日：2023-06-13
摘要： The current application discloses a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment and cosmetics of animal hair, in preference human hair. There are several hair styling methods that involve breakage and reestablishment of disulfide bonds, allowing relaxation and straightening of the hair. However, the most effective methods currently used to modulate hair contain harmful chemicals. Thus, there is a constant demand for formulations that efficiently model the hair fiber without damage. Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.
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公开(公告)号：US12112238B2
公开(公告)日：2024-10-08
申请号：US18068408
申请日：2022-12-19
申请人： ATOM COMPUTING INC.
发明人： Jonathan King , Benjamin Bloom , Krish Kotru , Brian Lester , Maxwell Parsons
摘要： The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation.
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公开(公告)号：US12110554B2
公开(公告)日：2024-10-08
申请号：US17157876
申请日：2021-01-25
申请人： VERACYTE, INC.
发明人： Giulia C. Kennedy , Bonnie H. Anderson , Darya I. Chudova , Eric T. Wang , Hui Wang , Moraima Pagan , Nusrat Rabbee , Jonathan I. Wilde
IPC分类号： C12Q1/6883 , C12Q1/6886
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.
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