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1.发明授权公开(公告)号：US12115262B2
公开(公告)日：2024-10-15
申请号：US17058339
申请日：2019-05-24
申请人： Elektrofi, Inc.
发明人： Chase Coffman , Lyndon Charles, Jr. , Paul Brown , Daniel Benjamin Dadon , Lisa Liu , Sadiqua Shadbar , Chaitanya Sudrik
CPC分类号： A61K9/5192 , A61K31/167 , A61K45/06 , A61K47/02 , A61K47/14 , A61K47/186 , A61K47/26
摘要： The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.
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公开(公告)号：US12110299B2
公开(公告)日：2024-10-08
申请号：US17277033
申请日：2019-09-11
发明人： Kwang Ok Lee , Jakyung Yoo , Jun Hee Lee , Mijung Lee , Kangwoo Lee , Jieun Min
IPC分类号： C07D498/18 , C07D277/46 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/18
CPC分类号： C07D498/18 , C07D277/46 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/18
摘要： The present invention provides a novel thiazole derivative or a pharmaceutically acceptable salt thereof, and a method for preparing the same. The thiazole derivative or pharmaceutically acceptable salt thereof according to the present invention has selective inhibitory activity against cyclin-dependent kinase (CDK) and thus can be used as a preventive or therapeutic agent for various diseases associated with CDK.
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公开(公告)号：US12097500B2
公开(公告)日：2024-09-24
申请号：US16852113
申请日：2020-04-17
发明人： Pengfei Xie , Mehdi Javanmard , Mark George Allen , Wen Shen , Naixin Song
CPC分类号： B01L3/5085 , G01N27/02 , G01N33/6863 , B01L2300/0636 , B01L2300/0645 , B01L2300/0893 , B01L2300/123
摘要： A sensor for detecting a target analyte in a sample includes a pair of conducting electrodes that are separated by a gap. An insulator is disposed in the gap between the electrodes. Plural wells are defined by one of the electrodes and the insulator, to expose the other of the electrodes. The wells are configured to receive a sample including a target analyte. The target analyte, when present in the sample received in the wells, modulates an impedance between the electrodes. The modulated impedance, which is measurable with an applied electrical voltage, is indicative of the concentration of the target analyte in the sample. The wells can include antibodies immobilized inside the wells, to bind the target analyte, which can be a cytokine. Also provided are a method for label-free sensing of a target analyte in a sample, and a transcutaneous impedance sensor for label-free, in-situ biomarker detection.
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公开(公告)号：US12095513B2
公开(公告)日：2024-09-17
申请号：US17804905
申请日：2022-06-01
发明人： Tommaso Melodia , Emrecan Demirors
摘要： Embodiments disclosed herein may be implemented in the form of a method or corresponding apparatus for receiving or transmitting network communications carried at acoustic wavelengths via an acoustic medium. The corresponding method or apparatus may include a gate-level digital hardware module communicatively coupled to a communications module and define therein logic blocks configured to perform respective primitive processing functions, sequences of the logic blocks being capable of processing data units in accordance with any of the multiple communications protocols on a data unit-by-data unit basis without reconfiguring. According to some embodiments, the gate-level digital hardware module may be configured to process a data unit in accordance with a first communications protocol by directing the data unit through a first sequence of logic blocks, and process a subsequent data unit in accordance with a second communications protocol by directing the subsequent data unit through a second of sequence logic blocks.
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公开(公告)号：US12086975B2
公开(公告)日：2024-09-10
申请号：US17586197
申请日：2022-01-27
申请人： DigiM Solution LLC
发明人： Shuang Zhang
CPC分类号： G06T7/0006 , G06T7/001 , G06T7/55 , G16H20/10
摘要： A method using high resolution imaging data, artificial intelligence-based quantitative image analytics, and image-based release prediction is disclosed to facilitate the determination of microstructure equivalence between two representative samples, such as pharmaceutical and material products. A computer-implemented method of evaluating microstructural equivalence of samples includes quantitatively comparing corresponding parameters of microstructure feature matrices, such as parameters for particle size distribution, porosity, uniformity of spatial distribution, and release rate of a material phase, to permit evaluating whether the samples meet a microstructural equivalence standard within an error tolerance.
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公开(公告)号：US12081365B2
公开(公告)日：2024-09-03
申请号：US18309124
申请日：2023-04-28
IPC分类号： H04L12/26 , G06Q40/04 , H04L12/417 , H04L45/24
CPC分类号： H04L12/417 , G06Q40/04 , H04L45/24
摘要： A distributed system includes a plurality of compute nodes configured to process messages. The compute nodes each process messages corresponding an assigned value of a common parameter of the messages. The values are assigned to the compute nodes such that two or more compute nodes are available to process each message. The values can be assigned to the compute nodes in a grouping configuration or a striping configuration. The compute nodes also circulate one or more tokens among nodes, and perform a self-maintenance operation during a given state of possession of the token. During a self-maintenance operation, the values assigned to the compute node can be reassigned to other compute nodes to ensure processing of corresponding messages.
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公开(公告)号：US12072491B2
公开(公告)日：2024-08-27
申请号：US16425088
申请日：2019-05-29
申请人： Kopin Corporation
发明人： Jeffrey J. Jacobsen
IPC分类号： G02B27/01
CPC分类号： G02B27/0172 , G02B27/0101 , G02B27/0149 , G02B27/0176 , G02B2027/014 , G02B2027/0192
摘要： A headset display system may comprise a head mounted display and a remote host device. The head mounted display may comprise a microdisplay and sensing components. The remote host device may communicate with the head mounted display, and formulate a task requirement based on information associated with a user of the headset display system. The remote host device may further search for and identify one or more wireless resources currently available to the remote host device, determine which of the identified wireless resources are suitable for satisfying the task requirement, and utilize the determined wireless resources to accomplish a task corresponding to the task requirement. The wireless resources may comprise at least one entity, external to the headset display system, that (i) generates a physical informational parameter, (ii) generates a process result, (iii) performs a data processing task, and/or (iv) accesses a communication and/or information storage resource.
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公开(公告)号：US12067602B2
公开(公告)日：2024-08-20
申请号：US18348501
申请日：2023-07-07
发明人： Leslie H. Swanson
IPC分类号： G06Q30/00 , G06F40/205 , G06F40/30 , G06F40/35 , G06N5/046 , G06Q30/0601
CPC分类号： G06Q30/0603 , G06F40/205 , G06F40/30 , G06F40/35 , G06N5/046 , G06Q30/0613
摘要： An intelligent product catalog system provides for electronic creation, management and viewing of product information using a multimedia display system. A central database repository stores the product information and provides for an unlimited number of product attributes and dynamic reconfiguration of the product information. The central database repository comprises a metadata system, a scheme system and an object model system. A plurality of applications access the central database repository, the applications being automatically adaptive to the dynamic reconfiguration of the product information. A user interface provides display, sorting and filtering of the product information including the unlimited number of product attributes.
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公开(公告)号：US12055452B2
公开(公告)日：2024-08-06
申请号：US18475515
申请日：2023-09-27
发明人： Gerardo A. Brucker
CPC分类号： G01L21/12 , B81B3/0018 , G01L9/0055 , G01L13/025 , G01L27/005 , B81B2201/0264
摘要： A load lock pressure gauge comprises a housing configured to be coupled to a load lock vacuum chamber. The housing supports an absolute vacuum pressure sensor that provides instantaneous high vacuum pressure signal over a range of high vacuum pressures and a differential diaphragm pressure sensor that provides an instantaneous differential pressure signal between load lock pressure and ambient pressure. The housing further supports an absolute ambient pressure sensor. A low vacuum absolute pressure is computed from the instantaneous differential pressure signal and the instantaneous ambient pressure signal. A controller in the housing is able to recalibrate the differential diaphragm pressure sensor based on measured voltages of the sensor and a measured ambient pressure during normal operation of the pressure gauge with routine cycling of pressure in the load lock.
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公开(公告)号：US12045322B2
公开(公告)日：2024-07-23
申请号：US16960960
申请日：2019-01-11
申请人： Virsec Systems, Inc.
发明人： Satya V. Gupta
CPC分类号： G06F21/121 , G06F9/30087 , G06F9/3842 , G06F9/3861 , G06F21/54 , G06F21/577
摘要： Embodiments protect a computer application from being exploited by an attacker, while the application code is executed by a speculative execution engine having vulnerabilities. Embodiments are directed to systems that, prior to execution of the application by a speculative execution engine, locate a sequence of instructions of the application in which the speculative execution engine executes the instructions out of sequence. For example, the sequence of instructions may be an “if-then” code block. The systems determine a disposition that forces the speculative execution engine to execute the instructions in sequence. For example, the disposition may be adding a fence instruction to the sequence of instructions. During execution of the application code by the speculative execution engine, the systems change the sequence of instructions based on the disposition. The systems execute the changed sequence of instructions in place of the located sequence of instructions to prevent an attack on the application.
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