利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.015 秒)

    METHODS AND KITS OF DETERMINING WHETHER A SUBJECT IS SUSCEPTIBLE TO HAVE A HYPER-AGGRESSIVE BEHAVIOUR
    2.
    发明申请
    METHODS AND KITS OF DETERMINING WHETHER A SUBJECT IS SUSCEPTIBLE TO HAVE A HYPER-AGGRESSIVE BEHAVIOUR 审中-公开
    方法和方法确定一个主体是否可以拥有一个更高的行为

    公开(公告)号：US20160123989A1

    公开(公告)日：2016-05-05

    申请号：US14898628

    申请日：2014-06-20

    申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE ROUEN ,  CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN ,  AKERSHUS UNIVERSITETSSYKEHUS HF

    发明人： Serguei FETISSOV ,  Pierre DECHELOTTE ,  Henning VÆRØY ,  Romain LEGRAND

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6854 ,  G01N33/74 ,  G01N2333/695

    摘要： The present invention relates to methods and kits of determining whether a subject is susceptible to have a hyper-aggressive behaviour. In particular, the present invention relates to a method for determining whether a subject is susceptible to have a hyper-aggressive behaviour comprising the steps consisting of i) isolating the auto antibodies that bind to adrenocorticotropic hormone (ACTH) from a blood sample obtained from the subject, ii) determining the affinity of the isolated autoantibodies iii) comparing the affinity determined at step ii) with a predetermined reference value and iv) concluding that the subject is susceptible to have a hyper-aggressive behaviour when the affinity determined at step ii) is higher than the predetermined reference value.

    摘要翻译： 本发明涉及确定受试者是否容易具有过度侵袭行为的方法和试剂盒。 特别地，本发明涉及一种用于确定受试者是否易于具有过度侵袭行为的方法，该方法包括以下步骤：i）从获得的血液样品中分离与促肾上腺皮质激素（ACTH）结合的自身抗体 主题，ii）确定分离的自身抗体的亲和力iii）将在步骤ii）中确定的亲和力与预定参考值进行比较，以及iv）当在步骤ii）确定的亲和力确定受试者易于具有过度侵袭行为时， 高于预定的参考值。

    CLEARANCE ASSAY
    3.
    发明公开
    CLEARANCE ASSAY 审中-公开

    公开(公告)号：US20240168011A1

    公开(公告)日：2024-05-23

    申请号：US18549388

    申请日：2022-03-08

    申请人： Akershus Universitetssykehus HF

    发明人： Tormod FLADBY ,  Marianne WETTERGREEN ,  Kulbhushan SHARMA ,  Berglind GISLADOTTIR ,  Bjørn-Eivind KIRSEBOM

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5035 ,  G01N33/5055 ,  G01N2333/4709 ,  G01N2800/2821

    摘要： An ex vivo method of determining the effect of an agent on catalysis by a Monocyte Phagocyte System (MPS) cell of a disease marker product and/or at least one fragment thereof associated with neurodegeneration and/or inflammatory activation. The method comprises: i) maintaining a sample of MPS cells under conditions in which the MPS cells remain alive, ii) exposing the sample of MPS cells to an agent and a disease marker product, to permit phagocytosis of the disease marker product by the MPS cells, iii) detecting the intracellular amount of the disease marker product and/or at least one fragment thereof in the sample of MPS cells, and iv) comparing the intracellular amount of the disease marker product and/or the at least one fragment thereof to an intracellular amount of the same disease marker product and/or at least one fragment thereof measured in control MPS cells in the absence of the agent. The effect of the agent on catalysis by MPS cells of the disease marker product and/or at least one fragment thereof is determined by the result of the comparison of step iv).

    Processing MRI data for analysis of tumors
    6.
    发明授权
    Processing MRI data for analysis of tumors 有权

    公开(公告)号：US11138729B2

    公开(公告)日：2021-10-05

    申请号：US16092036

    申请日：2017-04-20

    申请人： OSLO UNIVERSITETSSYKEHUS HF ,  AKERSHUS UNIVERSITETSSYKEHUS HF

    发明人： Kjell-Inge Gjesdal ,  Endre Grøvik ,  Kathrine Røe Redalen ,  Tryggve Holck Storås

    IPC分类号： G06T7/00 ,  A61B5/055 ,  A61B5/00

    摘要： Dynamic contrast enhanced MRI data and dynamic susceptibility contrast MRI data for a volume of the patient's body including a tumor are used in order to identify the risk of lymph node metastasis. A volume of interest enclosing the tumor is identified and the MRI data for the volume of interest is processed in order to identify one or more parameters relating to the transverse relaxation rate and/or to dynamic changes in the transverse relaxation rate. A comparison is made to previously obtained similar parameters for other patients having similar tumors that are either known to exhibit lymph node metastasis or are known not to exhibit lymph node metastasis in order to determine if the MRI data indicates that the patient has a tumor at greater risk of exhibiting lymph node metastasis or a tumor with a lesser risk of exhibiting lymph node metastasis.

    PROCESSING MRI DATA FOR ANALYSIS OF TUMORS
    7.
    发明申请
    PROCESSING MRI DATA FOR ANALYSIS OF TUMORS 审中-公开

    公开(公告)号：US20190156479A1

    公开(公告)日：2019-05-23

    申请号：US16092036

    申请日：2017-04-20

    申请人： OSLO UNIVERSITETSSYKEHUS HF ,  AKERSHUS UNIVERSITETSSYKEHUS HF

    发明人： Kjell-Inge GJESDAL ,  Endre GRØVIK ,  Kathrine Røe REDALEN ,  Tryggve Holck STORÅS

    IPC分类号： G06T7/00 ,  A61B5/055 ,  A61B5/00

    摘要： Dynamic contrast enhanced MRI data and dynamic susceptibility contrast MRI data for a volume of the patient's body including a tumor are used in order to identify the risk of lymph node metastasis. A volume of interest enclosing the tumor is identified and the MRI data for the volume of interest is processed in order to identify one or more parameters relating to the transverse relaxation rate and/or to dynamic changes in the transverse relaxation rate. A comparison is made to previously obtained similar parameters for other patients having similar tumors that are either known to exhibit lymph node metastasis or are known not to exhibit lymph node metastasis in order to determine if the MRI data indicates that the patient has a tumor at greater risk of exhibiting lymph node metastasis or a tumor with a lesser risk of exhibiting lymph node metastasis.