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    METHODS AND KITS OF DETERMINING WHETHER A SUBJECT IS SUSCEPTIBLE TO HAVE A HYPER-AGGRESSIVE BEHAVIOUR
    7.
    发明申请
    METHODS AND KITS OF DETERMINING WHETHER A SUBJECT IS SUSCEPTIBLE TO HAVE A HYPER-AGGRESSIVE BEHAVIOUR 审中-公开
    方法和方法确定一个主体是否可以拥有一个更高的行为

    公开(公告)号：US20160123989A1

    公开(公告)日：2016-05-05

    申请号：US14898628

    申请日：2014-06-20

    申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE ROUEN ,  CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN ,  AKERSHUS UNIVERSITETSSYKEHUS HF

    发明人： Serguei FETISSOV ,  Pierre DECHELOTTE ,  Henning VÆRØY ,  Romain LEGRAND

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6854 ,  G01N33/74 ,  G01N2333/695

    摘要： The present invention relates to methods and kits of determining whether a subject is susceptible to have a hyper-aggressive behaviour. In particular, the present invention relates to a method for determining whether a subject is susceptible to have a hyper-aggressive behaviour comprising the steps consisting of i) isolating the auto antibodies that bind to adrenocorticotropic hormone (ACTH) from a blood sample obtained from the subject, ii) determining the affinity of the isolated autoantibodies iii) comparing the affinity determined at step ii) with a predetermined reference value and iv) concluding that the subject is susceptible to have a hyper-aggressive behaviour when the affinity determined at step ii) is higher than the predetermined reference value.

    摘要翻译： 本发明涉及确定受试者是否容易具有过度侵袭行为的方法和试剂盒。 特别地，本发明涉及一种用于确定受试者是否易于具有过度侵袭行为的方法，该方法包括以下步骤：i）从获得的血液样品中分离与促肾上腺皮质激素（ACTH）结合的自身抗体 主题，ii）确定分离的自身抗体的亲和力iii）将在步骤ii）中确定的亲和力与预定参考值进行比较，以及iv）当在步骤ii）确定的亲和力确定受试者易于具有过度侵袭行为时， 高于预定的参考值。

    METHODS AND KITS FOR TESTING THE GENOTOXICITY OF AN AGENT
    8.
    发明申请
    METHODS AND KITS FOR TESTING THE GENOTOXICITY OF AN AGENT 审中-公开
    用于测试代谢物的致病性的方法和试剂盒

    公开(公告)号：US20160084823A1

    公开(公告)日：2016-03-24

    申请号：US14785489

    申请日：2014-04-17

    申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  UNIVERSITÉ DE ROUEN ,  CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN

    发明人： Jean-Michel FLAMAN ,  Thierry FREBOURG ,  Gaelle BOUGEARD ,  Yasmine ZERDOUMI

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5023 ,  G01N33/5014

    摘要： The present invention relates to methods and kits for testing the genotoxicity of an agent. In particular, the present invention provides a global assay for the measurement of genotoxic stress based on p53 target gene induction. In particular, the present invention relates to a method for testing the genotoxicity of an agent comprising the steps consisting of i) providing a population of test cells, ii) exposing the populations of test cells with the agent to be tested, iii) determining the expression level of at least one p53 target gene selected from the group consisting of ATF3, BBC3, CABYR, C10ORF10; EMX1; FHL2, GLS2; GRHL3; HES2; IGF-BP4; KIAA0284; PODXL1; RRAD; TP53I3, and XPC in the population of test cells exposed to the agent to be tested iv) comparing the expression level determined at step iii) with the expression level determined when the population of test cells was not exposed to the agent to be tested, and v) concluding that the agent is genotoxic when the expression level determined at step iii) is higher than the level determined when the population of test cells was not exposed to the agent to be tested.

    摘要翻译： 本发明涉及用于测试药剂基因毒性的方法和试剂盒。 特别地，本发明提供了基于p53靶基因诱导测量基因毒性应激的全局测定。 特别地，本发明涉及一种用于测试药剂的基因毒性的方法，包括以下步骤：i）提供一组测试细胞，ii）将测试细胞群暴露于待测试的试剂中，iii）确定 至少一种选自ATF3，BBC3，CABYR，C10ORF10的p53靶基因的表达水平; EMX1; FHL2，GLS2; GRHL3; HES2; IGF-BP4; KIAA0284; PODXL1; RRAD; TP53I3和XPC在暴露于待测试试剂的测试细胞群体中iv）将步骤iii）中确定的表达水平与当测试细胞群体未暴露于待测试试剂时测定的表达水平进行比较，以及 v）得出结论，当在步骤iii）中确定的表达水平高于当测试细胞群体未暴露于待测试试剂时确定的水平时，该试剂是基因毒性。