公开(公告)号：US20220331258A1

公开(公告)日：2022-10-20

申请号：US17765862

申请日：2020-09-30

申请人： Allergan Sales, LLC

发明人： Patrick Hughes ,  Hongwen Rivers ,  Jie Shen ,  Johan Zuidema ,  Henk Haitjema ,  Christine Hiemstra ,  Rob Steendam

IPC分类号： A61K9/50 ,  A61K38/17 ,  C08G81/00 ,  A61K9/00

摘要： Provided herein are poly(ether ester) multi-block copolymers (PEE-MBCP). Also provided herein are injectable delivery systems or pharmaceutical compositions, comprising a PEE-MBCP provided herein, either alone or in combination with a binding protein, such as abicipar. Also provided herein are methods of using these injectable delivery systems or pharmaceutical compositions provided herein for the treatment of ocular disorders.

公开(公告)号：US20220117977A1

公开(公告)日：2022-04-21

申请号：US17564400

申请日：2021-12-29

申请人： ALLERGAN SALES, LLC

发明人： Charles Ebert ,  Gary Hoel ,  Angela Anigbogu ,  Samir Roy

IPC分类号： A61K31/57 ,  A61K9/70 ,  A61K31/565

摘要： Formulations and methods for providing progestin-only contraception to a woman including transdermally administering to a woman a formulation having a contraceptively effective amount of progestin-only hormonal agents as part of a contraceptive regimen.

公开(公告)号：US11202786B2

公开(公告)日：2021-12-21

申请号：US16583140

申请日：2019-09-25

申请人： ALLERGAN SALES, LLC

发明人： Robert M. Moriarty ,  Nathaniel E. David ,  Nadir Ahmeduddin Mahmood

IPC分类号： A61K31/575 ,  C07J9/00 ,  A61K45/06

摘要： Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.

公开(公告)号：US20210254008A1

公开(公告)日：2021-08-19

申请号：US17112911

申请日：2020-12-04

申请人： Allergan Sales, LLC

发明人： Patrick Nido

IPC分类号： C12N5/077 ,  A61Q19/00 ,  A61K8/97 ,  A61K8/99 ,  A61K8/64 ,  A61K35/33

摘要： The production and use of extracellular matrix or conditioned medium compositions and more specifically to compositions obtained by culturing cells under hypoxic conditions on a surface in a suitable growth medium.

公开(公告)号：US11008363B2

公开(公告)日：2021-05-18

申请号：US16856374

申请日：2020-04-23

申请人： ALLERGAN SALES, LLC

发明人： Achampeta Rathan Prasad ,  Roy A. Swaringen, Jr. ,  John Gregory Reid ,  Robert M. Moriarty ,  Akhila Kumar Sahoo

IPC分类号： C07J9/00 ,  C07J75/00 ,  C07J1/00 ,  C07J13/00

摘要： Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.

公开(公告)号：US10946030B2

公开(公告)日：2021-03-16

申请号：US15663356

申请日：2017-07-28

申请人： ALLERGAN SALES, LLC

发明人： Robert Emil Hodge ,  Jeffrey Douglas Webster ,  Robert M. Moriarty

IPC分类号： A61K31/57 ,  A61K31/575 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10

摘要： The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.

公开(公告)号：US20200078354A1

公开(公告)日：2020-03-12

申请号：US16684622

申请日：2019-11-15

申请人： Allergan Sales, LLC

发明人： Rahul Sareen ,  Shahin Fesharaki ,  Parag Shah

IPC分类号： A61K31/485 ,  A61K9/20 ,  A61K9/46

摘要： The invention relates to an abuse deterrent immediate release tablet.

公开(公告)号：US10434107B2

公开(公告)日：2019-10-08

申请号：US15940941

申请日：2018-03-29

申请人： ALLERGAN SALES, LLC

发明人： Robert M. Moriarty ,  Nathaniel E. David ,  Nadir Ahmeduddin Mahmood

IPC分类号： C07J9/00 ,  A61K31/575 ,  A61K47/24 ,  A61K45/06 ,  A61K38/08

摘要： Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.

公开(公告)号：US20170304297A1

公开(公告)日：2017-10-26

申请号：US15640823

申请日：2017-07-03

申请人： Allergan Sales, LLC

发明人： Rahul Sareen ,  Shahin Fesharaki ,  Parag Shah

IPC分类号： A61K31/485 ,  A61K9/20 ,  A61K9/46

CPC分类号： A61K31/485 ,  A61K9/0007 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2059

摘要： The invention relates to an abuse deterrent immediate release tablet.

公开(公告)号：US20170095438A1

公开(公告)日：2017-04-06

申请号：US15348478

申请日：2016-11-10

申请人： Allergan Sales, LLC

发明人： Charles D. Ebert ,  Steven W. Sanders

IPC分类号： A61K31/216 ,  A61K47/10 ,  A61K9/70 ,  A61K9/16 ,  A61K9/06 ,  A61K9/00

CPC分类号： A61K31/216 ,  A61F2013/00646 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/1647 ,  A61K9/7061 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K2300/00

摘要： The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.