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公开(公告)号：US20160177299A1
公开(公告)日：2016-06-23
申请号：US14897577
申请日：2014-06-05
申请人： APSE LLC
发明人： Juan Pedro Humberto ARHANCET , JUAN P. ARHANCET , Kimberly DELANEY , Kathleen B. HALL , Neena SUMMERS , Edward OATES
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K9/5184 , A61K48/00 , C07K14/005 , C12N15/111 , C12N2310/12 , C12N2310/121 , C12N2310/14 , C12N2310/141 , C12N2310/3519 , C12N2310/531 , C12N2320/32 , C12N2330/50 , C12N2795/00023 , C12N2795/00042 , C12N2795/18122 , C12N2795/18123 , C12N2795/18142
摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.
摘要翻译： 描述了新的方法和组合物，其使用对水解酶具有抗性的病毒衣壳蛋白来制备病毒样颗粒以包围并随后分离和纯化目标物质分子，包括核酸如siRNA和shRNA，miRNA，信使RNA，小肽和生物活性 分子。
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公开(公告)号：US09822361B2
公开(公告)日：2017-11-21
申请号：US14897577
申请日：2014-06-05
申请人： APSE LLC
发明人： Juan Pedro Humberto Arhancet , Juan P. Arhancet , Kimberly Delaney , Kathleen B. Hall , Neena Summers , Edward Oates
IPC分类号： C12N15/11 , C12N15/113 , A61K48/00 , A61K9/51
CPC分类号： C12N15/113 , A61K9/5184 , A61K48/00 , C07K14/005 , C12N15/111 , C12N2310/12 , C12N2310/121 , C12N2310/14 , C12N2310/141 , C12N2310/3519 , C12N2310/531 , C12N2320/32 , C12N2330/50 , C12N2795/00023 , C12N2795/00042 , C12N2795/18122 , C12N2795/18123 , C12N2795/18142
摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.
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公开(公告)号：US20160208221A1
公开(公告)日：2016-07-21
申请号：US14914553
申请日：2014-09-12
申请人： APSE, LLC
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N15/88 , C12N2795/18122 , C12N2795/18123 , C12N2795/18151
摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.
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公开(公告)号：US20140302593A1
公开(公告)日：2014-10-09
申请号：US14279793
申请日：2014-05-16
申请人： APSE, LLC
发明人： Juan Pedro Humberto Arhancet , Juan P. Arhancet , Kimberly Delaney , Kathleen B. Hall , Neena Summers
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A01N25/26 , A01N25/28 , C07K14/005 , C07K14/01 , C12N7/04 , C12N15/111 , C12N15/113 , C12N2310/121 , C12N2310/123 , C12N2310/128 , C12N2310/14 , C12N2310/16 , C12N2330/51 , C12N2795/18122 , C12N2795/18123 , C12N2795/18142 , A01N43/70 , A01N47/40 , A01N57/12 , A01N57/14 , A01N57/30 , C12N2310/531
摘要： Processes and compositions to produce, package, and purify virus like particles containing heterologous cargo molecules utilizing self assembling proteins and protease treatment coupled with simple precipitation and filtration methods are described.
摘要翻译： 描述了使用自组装蛋白和蛋白酶处理与简单沉淀和过滤方法一起生产，包装和纯化含有异源货物分子的病毒样颗粒的方法和组合物。
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公开(公告)号：US20180291066A1
公开(公告)日：2018-10-11
申请号：US15570711
申请日：2016-05-09
申请人： APSE, LLC
IPC分类号： C07K14/005 , C12N7/00
摘要： Methods and compositions for producing, isolating and purifying virus-like particles (VLPs) containing long sense and antisense RNA molecules, including RNA molecules predicted to fold into double-stranded regions longer than the inner diameter of the VLP capsids are disclosed.
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公开(公告)号：US09181531B2
公开(公告)日：2015-11-10
申请号：US14279793
申请日：2014-05-16
申请人： APSE, LLC
发明人： Juan Pedro Humberto Arhancet , Juan P. Arhancet , Kimberly Delaney , Kathleen B. Hall , Neena Summers
IPC分类号： C12N7/01 , C12N15/113 , C12N7/04 , C07K14/01 , C12N7/00 , A01N25/26 , A01N25/28 , C12N15/11 , C07K14/005
CPC分类号： C12N7/00 , A01N25/26 , A01N25/28 , C07K14/005 , C07K14/01 , C12N7/04 , C12N15/111 , C12N15/113 , C12N2310/121 , C12N2310/123 , C12N2310/128 , C12N2310/14 , C12N2310/16 , C12N2330/51 , C12N2795/18122 , C12N2795/18123 , C12N2795/18142 , A01N43/70 , A01N47/40 , A01N57/12 , A01N57/14 , A01N57/30 , C12N2310/531
摘要： Processes and compositions to produce, package, and purify virus like particles containing heterologous cargo molecules utilizing self assembling proteins and protease treatment coupled with simple precipitation and filtration methods are described.
摘要翻译： 描述了使用自组装蛋白和蛋白酶处理与简单沉淀和过滤方法一起生产，包装和纯化含有异源货物分子的病毒样颗粒的方法和组合物。
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公开(公告)号：US20130167267A1
公开(公告)日：2013-06-27
申请号：US13725184
申请日：2012-12-21
申请人： Apse, LLC
发明人： Juan Pedro Humberto Arhancet , Juan P. Arhancet , Kimberly Delaney , Kathleen B. Hall , Neena Summers
IPC分类号： C07K14/01 , C12N15/113 , A01N25/26
CPC分类号： C12N7/00 , A01N25/26 , A01N25/28 , C07K14/005 , C07K14/01 , C12N7/04 , C12N15/111 , C12N15/113 , C12N2310/121 , C12N2310/123 , C12N2310/128 , C12N2310/14 , C12N2310/16 , C12N2330/51 , C12N2795/18122 , C12N2795/18123 , C12N2795/18142 , A01N43/70 , A01N47/40 , A01N57/12 , A01N57/14 , A01N57/30 , C12N2310/531
摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides.
摘要翻译： 描述了新的方法和组合物，其使用对水解酶具有抗性的病毒衣壳蛋白，以制备病毒样颗粒以包围并随后分离和纯化目标载体分子，包括核酸如siRNA和shRNA以及小肽。
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公开(公告)号：US20180265868A1
公开(公告)日：2018-09-20
申请号：US15763431
申请日：2016-09-30
申请人： APSE, LLC
发明人： Juan P. H. ARHANCET
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N15/8218 , C12N15/8286 , C12N2310/14 , C12N2310/15 , C12N2310/531 , C12N2320/32 , C12N2320/51 , C12N2330/50 , Y02A40/162
摘要： The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming pseudoknots and being encapsidated in Virus Like Particles having higher insect control efficacy than previously described RNA molecules.
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