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    CONCENTRATED, INHALABLE CIPROFLOXACIN FORMULATION
    4.
    发明申请
    CONCENTRATED, INHALABLE CIPROFLOXACIN FORMULATION 有权
    浓缩，可吸入的CIPROFLOXACIN配方

    公开(公告)号：US20170035753A1

    公开(公告)日：2017-02-09

    申请号：US15299284

    申请日：2016-10-20

    申请人： ARADIGM CORPORATION

    发明人： DAVID C. CIPOLLA ,  James BLANCHARD

    IPC分类号： A61K31/496 ,  A61K47/22 ,  A61K9/00 ,  A61K9/127

    摘要： A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions.

    摘要翻译： 公开了一种抗生素药物如环丙沙星的浓缩可吸入制剂。 抗生素用含有抗生素的乙酸钠和脂质体配制。 该制剂被雾化并吸入以治疗呼吸道感染和其他医学状况。

    Pore structures for reduced pressure aerosolization
    5.
    发明授权
    Pore structures for reduced pressure aerosolization 有权

    公开(公告)号：US09511199B2

    公开(公告)日：2016-12-06

    申请号：US14157134

    申请日：2014-01-16

    申请人： ARADIGM CORPORATION

    发明人： Rajesh S. Patel ,  Sudarsan Srinivasan

    IPC分类号： B05B1/08 ,  A61M15/00

    CPC分类号： A61M15/009 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  Y10T29/49826

    摘要： A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.

    NANOCRYSTALS FORMED IN A MICROENVIRONMENT
    6.
    发明申请
    NANOCRYSTALS FORMED IN A MICROENVIRONMENT 审中-公开
    在微环境中形成的纳米晶体

    公开(公告)号：US20160120806A1

    公开(公告)日：2016-05-05

    申请号：US14993281

    申请日：2016-01-12

    申请人： ARADIGM CORPORATION

    发明人： David C. CIPOLLA ,  Igor GONDA

    IPC分类号： A61K9/127 ,  A61K31/496

    CPC分类号： A61K9/127 ,  A61K9/0078 ,  A61K9/1277 ,  A61K31/496 ,  A61K47/26 ,  Y02A50/406

    摘要： A formulation is disclosed which is comprised of a first solvent having a first active ingredient dissolved therein a plurality of microenvironments dispersed in the first solvent, the microenvironment being comprised of a shell having a dimension in a range of 50 nanometers to 100, the shell comprising an internal volume comprising a second solvent having a second active ingredient dissolved therein and nanocrystals of the second active ingredient.

    摘要翻译： 公开了一种配方，其由具有溶解在其中的分散在第一溶剂中的多个微环境的第一活性成分的第一溶剂组成，微环境由尺寸在50纳米至100范围内的壳体组成，壳体包含 内部体积，其包含溶解有第二活性成分的第二溶剂和第二活性成分的纳米晶体。