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公开(公告)号:US20170166868A1
公开(公告)日:2017-06-15
申请号:US15443374
申请日:2017-02-27
发明人: Michael Coleman , Ivone Bruno , Rudy Martinez , Amir Sanchez , Eckhard Alt , Frank D. Marcum , Paul Shealy
IPC分类号: C12N5/0775 , A01N1/02
CPC分类号: C12N5/0667 , A01N1/0221 , A01N1/0284 , A61K31/737 , A61K35/28 , C12N5/0018 , C12N2501/90 , C12N2501/905 , C12N2533/70 , C12N2533/80 , C12N2539/00 , A61K2300/00
摘要: A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.
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公开(公告)号:US20180221413A1
公开(公告)日:2018-08-09
申请号:US15928509
申请日:2018-03-22
发明人: Frank D. Marcum
IPC分类号: A61K35/28 , A61K31/728
CPC分类号: A61K35/28 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61K31/715 , A61K31/728 , A61K35/35 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/27 , A61K38/30 , A61K45/06 , A61L27/26 , A61L27/34 , A61L27/3834 , A61L27/3852 , A61L27/54 , A61L2300/41 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2400/06 , C08L5/08 , A61K2300/00
摘要: A pharmaceutical preparation and method for treating connective tissue damage in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a glycosaminoglycan composition comprising chondroitin sulfate, hyaluronan, and N-acetyl D-glucosamine, wherein the connective tissue is skin.
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