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1.发明公开公开(公告)号：US20240360401A1
公开(公告)日：2024-10-31
申请号：US18287728
申请日：2022-04-21
Applicant: ETABLISSEMENT FRANÇAIS DU SANG , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE DE STRASBOURG , AVIGNON UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE D'AIX MARSEILLE , ECOLE CENTRALE DE MARSEILLE
Inventor： Catherine STRASSEL , Léa MALLO , Valentin DO SACRAMENTO , Eric BERTRAND , Yannick KNAPP
Abstract: The disclosure relates to a method for releasing platelets from megakaryocytes contained in a fluid (F), the method being carried out by means of a system comprising two concentric cylinders, an inner cylinder comprising a cylindrical wall and a hollow outer cylinder located radially external to the inner cylinder, the outer cylinder comprising a cylindrical wall of a base at which the second cylinder is closed, the cylinders being separated by a space devoid of any mechanical parts, the space being intended to receive the fluid (F), the method comprising the following steps: supplying the space with a fluid (F) comprising megakaryocytes, rotating the inner cylinder about its axis, the outer cylinder being stationary, or moving the two cylinders in opposite directions about their axes, so as to generate an at least partially turbulent flow of fluid (F) in the space and obtain a second fluid (F′) enriched in platelets.
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公开(公告)号：US12016957B2
公开(公告)日：2024-06-25
申请号：US17297530
申请日：2019-11-27
Applicant: AVIGNON UNIVERSITE , LYOFAL , Centre National de la Recherche Scientifique , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER , UNIVERSITE DE MONTPELLIER
Inventor： Christiane Contino-Pepin , Stéphane Desgranges , Alice Dall'armellina , Charles Duval , Mathias Letan-Martin
IPC: A61K36/00 , A23L33/105 , A61K9/19 , A61K36/53 , A61K36/752 , A61K36/9066 , A61K47/14 , A61K47/44 , B01D11/02
CPC classification number: A61K9/19 , A23L33/105 , A61K36/53 , A61K36/752 , A61K36/9066 , A61K47/14 , A61K47/44 , B01D11/0265 , A23V2002/00 , A61K2236/331 , A61K2236/35 , A61K2236/51
Abstract: The present description relates to a method for extracting at least one substance of interest, the method comprising the following steps: —providing an admixture comprising water, a source comprising the at least one substance of interest or at least one precursor thereof, at least one surfactant and at least one lipophilic compound; —the emulsification of the admixture, leading to the formation of an emulsion; wherein the emulsion comprises: —a continuous aqueous phase; and a discontinuous lipidic phase comprising the at least one lipophilic compound, the at least one surfactant and at least one substance of interest extracted from the source during the emulsification; wherein the method further comprises the addition of at least one cryoprotectant to the admixture and the lyophilization of the emulsion.
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公开(公告)号：US20210252172A1
公开(公告)日：2021-08-19
申请号：US17252100
申请日：2019-06-14
Applicant: AVIGNON UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , SORBONNE UNIVERSITE , UNIVERSITE DE MONTPELLIER , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventor： Christiane Contino-Pepin , Stéphane Desgranges , Nicolas Taulier
Abstract: The present description relates to an emulsion comprising an amphiphilic compound, a first phase comprising droplets including at least one perfluorocarbon compound and a second phase, which is aqueous. The droplets have a diameter d4,3 of between 0.5 pm and 5.5 pm, and the at least one perfluorocarbon compound has a boiling point above 100° C. The present description also relates to such an emulsion for use as an improving agent in ultrasound ablation surgery (FIG. 3).
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4.发明公开公开(公告)号：US20230191383A1
公开(公告)日：2023-06-22
申请号：US17999346
申请日：2021-05-27
Applicant: UNIVERSITE DE STRASBOURG , AVIGNON UNIVERSITE , Centre National de la Recherche Scientifique , UNIVERSITE DE MONTPELLIER , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventor： Frédéric Bihel , Damien Bourgeois , Christiane Contino-Pepin , Stéphane Desgranges , Valentin Lacanau
CPC classification number: B01J31/064 , B01J31/22 , B01J31/0209 , B01J35/0013 , B01J2531/16 , B01J2531/842
Abstract: A dry formulation obtained by desiccation of an emulsion comprises at least one surfactant, at least one lipophilic compound, and at least one metal catalyst. The dry formulation may be used to carry out a catalysed reaction in an aqueous medium. The dry formulation has a water content of less than (10) wt% relative to the total weight of the dry formulation, and wherein: - the at least one surfactant is selected from the group comprising dendrimers of Dendri-TAC type, oligomers of F,TACn or H,TACn type, TPGS 1000, TPGS 750 M, surfactants derived from sugars and/or amino acids, and combinations thereof; - the at least one lipophilic compound is selected from the group comprising lipids, hydrophobic complexing agents and combinations thereof; and - the metal catalyst comprises a metal selected from Groups (3) to (12) of the Periodic Table.
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Patent Agency Ranking
公开(公告)号：US20220313875A1
公开(公告)日：2022-10-06
申请号：US17764686
申请日：2020-10-12
Applicant: ETABLISSEMENT FRANCAIS DU SANG , AVIGNON UNIVERSITE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , UNIVERSITE DE STRASBOURG
Inventor： Valentin DO SACRAMENTO , Yannick KNAPP , Lea MALLO , Catherine STRASSEL
Abstract: The invention relates to a system for platelet release from a fluid comprising in particular megakaryocytic cells comprising cytoplasmic extensions.
The system allows to reproduce the pipetting process performed manually by means of a pipette, thereby permitting a continuous and automatic release of platelets.
This is performed on a large scale since the geometry of the system according to the invention allows to treat large volumes of fluid with a high flow rate (of the order of a plurality of liters per hour), thereby making it particularly suitable for use on an industrial scale.
The invention also relates to a method for platelet release from a fluid comprising in particular megakaryocytic cells comprising cytoplasmic extensions, said method being implemented by means of the abovementioned system.-
公开(公告)号：US12251451B2
公开(公告)日：2025-03-18
申请号：US17252100
申请日：2019-06-14
Applicant: AVIGNON UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , SORBONNE UNIVERSITE , UNIVERSITE DE MONTPELLIER , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventor： Christiane Contino-Pepin , Stéphane Desgranges , Nicolas Taulier
Abstract: The present description relates to an injectable emulsion comprising an amphiphilic compound, a first phase comprising droplets including at least one perfluorocarbon compound and a second phase, which is aqueous. The droplets have a diameter d4,3 of between 0.5 pm and 5.5 pm, and the at least one perfluorocarbon compound has a boiling point above 100° C. The present description also relates to methods comprising administering such an injectable emulsion in, for example, ultrasound ablation surgery (FIG. 3).
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公开(公告)号：US20220008340A1
公开(公告)日：2022-01-13
申请号：US17297530
申请日：2019-11-27
Applicant: AVIGNON UNIVERSITE , LYOFAL , Centre National de la Recherche Scientifique , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER , UNIVERSITE DE MONTPELLIER
Inventor： Christiane Contino-Pepin , Stéphane Desgranges , Alice Dall`armellina , Charles Duval , Mathias Letan-Martin
IPC: A61K9/19 , A61K36/9066 , A61K47/44 , A61K47/14 , A61K36/53 , A61K36/752 , B01D11/02 , A23L33/105
Abstract: The present description relates to a method for extracting at least one substance of interest, the method comprising the following steps: —providing an admixture comprising water, a source comprising the at least one substance of interest or at least one precursor thereof, at least one surfactant and at least one lipophilic compound; —the emulsification of the admixture, leading to the formation of an emulsion; wherein the emulsion comprises: —a continuous aqueous phase; and a discontinuous lipidic phase comprising the at least one lipophilic compound, the at least one surfactant and at least one substance of interest extracted from the source during the emulsification; wherein the method further comprises the addition of at least one cryoprotectant to the admixture and the lyophilisation of the emulsion.
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公开(公告)号：US20240247207A1
公开(公告)日：2024-07-25
申请号：US18288397
申请日：2022-04-29
Applicant: AVIGNON UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE MONTPELLIER , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventor： GRÉGORY DURAND , MOHEDDINE WEHBIE
IPC: C11D1/00 , C07C317/28 , C07H15/06 , C07H15/18 , C07K14/245
CPC classification number: C11D1/004 , C07C317/28 , C07H15/06 , C07H15/18 , C07K14/245 , C07C2601/14
Abstract: The present invention relates to new amphiphilic perfluorinated compounds and their use as a detergent for extracting membrane-proteins or synthesizing membrane-proteins in acellular system. It also relates to a method for extracting a membrane-protein from a biological sample using such compounds.
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公开(公告)号：US20220370394A1
公开(公告)日：2022-11-24
申请号：US17774684
申请日：2020-11-06
Applicant: GIVAUDAN SA , AVIGNON UNIVERSITE , L'UNIVERSITÉ DE MONTPELLIER , LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , L,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Inventor： Doria BOULGHOBRA , Michael LAGUERRE , Mathieu TENON , Jérémy FAUCONNIER , Simona BIRTIC , Pascale Elizabeth Renée FANÇA-BERTHON , Cyril REBOUL , Olivier CAZORLA
IPC: A61K31/216 , A61K36/31 , A23L33/105 , A61P21/06
Abstract: The present invention relates to compounds having a lipid affinity of less than 15% by weight of the compound (such as a log P of −0.75 or less) for use in targeting mitochondria to reduce, inhibit or prevent the formation of mitochondrial reactive oxygen species and for use in treating or preventing a pathological condition associated with increased levels of mitochondrial reactive oxygen species, and for non-therapeutic uses, such as enhancing sports performance and reducing, inhibiting or preventing the formation of mitochondrial reactive oxygen species during exercise, resulting in maintenance of muscle strength and/or a reduction in muscle fatigue, and associated methods. The present invention also relates to extracts and compositions comprising compounds having a lipid affinity of less than 15% (such as a log P of −0.75 or less) for the same uses.
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