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    APPARATUS FOR EFFECTIVE ABLATION AND NERVE SENSING ASSOCIATED WITH DENERVATION
    3.
    发明申请
    APPARATUS FOR EFFECTIVE ABLATION AND NERVE SENSING ASSOCIATED WITH DENERVATION 有权

    公开(公告)号：US20210204854A1

    公开(公告)日：2021-07-08

    申请号：US17127443

    申请日：2020-12-18

    申请人： Ablative Solutions, Inc.

    发明人： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

    IPC分类号： A61B5/24 ,  A61B5/00 ,  A61B18/14

    摘要： An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

    Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
    5.
    发明授权
    Expandable catheter system for fluid injection into and deep to the wall of a blood vessel 有权

    公开(公告)号：US11007329B2

    公开(公告)日：2021-05-18

    申请号：US16178940

    申请日：2018-11-02

    申请人： ABLATIVE SOLUTIONS, INC.

    发明人： David R. Fischell ,  Tim A. Fischell

    IPC分类号： A61F5/40 ,  A61M5/46 ,  A61M25/00 ,  A61M25/06 ,  A61B5/00

    摘要： A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

    Methods of ablating tissue using a catheter injection system
    6.
    发明授权
    Methods of ablating tissue using a catheter injection system 有权

    公开(公告)号：US11007008B2

    公开(公告)日：2021-05-18

    申请号：US15711162

    申请日：2017-09-21

    申请人： Ablative Solutions, Inc.

    发明人： David R. Fischell ,  Tim A. Fischell

    IPC分类号： A61B18/00 ,  A61B18/14 ,  A61M5/00

    摘要： At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.