公开(公告)号：US20060280817A1

公开(公告)日：2006-12-14

申请号：US11440790

申请日：2006-05-25

申请人： Ajit Saxena ,  Bishan Gupta ,  Bal Kapahi ,  Shanmugavel Muthiah ,  Dilip Mondhe ,  Baleshwar ,  Ghulam Qazi ,  Vijay Kumar ,  Ganeshan Mathan

发明人： Ajit Saxena ,  Bishan Gupta ,  Bal Kapahi ,  Shanmugavel Muthiah ,  Dilip Mondhe ,  Baleshwar ,  Ghulam Qazi ,  Vijay Kumar ,  Ganeshan Mathan

IPC分类号： A61K36/48

CPC分类号： A61K36/48

摘要： The present invention relates to anticancer activity against hepatocellular carcinoma of an extract and fraction isolated from flowers of Butea monosperma. Particularly, this invention relates to anticancer activity against hepatocellular carcinoma of a composition containing markered flavonoid glycosides such as butrin and isobutrin in the range of 2 to 9% by weight, isolated from the flowers of Butea monosperma by extracting the flowers with polar solvent like ethanol, methanol, aqueous ethanol or water, removing fatty non-polar constituents by triturating the extract with solvents such as ethylene chloride, methylene chloride, chloroform or ethyl acetate, suspending the residue in water, extracting with n-butanol and freeze drying the aqueous part.

摘要翻译： 本发明涉及一种提取物对肝细胞癌的抗癌活性和从白花单倍体花中分离的部分。 特别地，本发明涉及通过用极性溶剂如乙醇提取鲜花，从含有白芍的花中分离出含有2至9重量％的标记的类黄酮苷类的标记黄酮糖苷类化合物的抗癌活性 ，甲醇，乙醇水溶液或水中，通过用溶剂如氯化乙烯，二氯甲烷，氯仿或乙酸乙酯研磨提取物除去脂肪非极性组分，将残余物悬浮在水中，用正丁醇萃取并冷冻干燥含水部分 。

公开(公告)号：US20090298938A1

公开(公告)日：2009-12-03

申请号：US12401337

申请日：2009-03-10

申请人： Ghulam Nabi Qazi ,  Subhash Chandra Taneja ,  Jaswant Singh ,  Ajit Kumar Saxena ,  Vijay Kumar Sethi ,  Bhahwal Ali Shah ,  Bal Krishan Kapahi ,  Samar Singh Andotra ,  Ajay Kumar ,  Shashi Bhushan ,  Fayaz Malik ,  Dilip Manikrao Mondhe ,  Shanmugavel Muthiah ,  Surjeet Singh ,  Monika Verma ,  Shashank Kumar Singh

发明人： Ghulam Nabi Qazi ,  Subhash Chandra Taneja ,  Jaswant Singh ,  Ajit Kumar Saxena ,  Vijay Kumar Sethi ,  Bhahwal Ali Shah ,  Bal Krishan Kapahi ,  Samar Singh Andotra ,  Ajay Kumar ,  Shashi Bhushan ,  Fayaz Malik ,  Dilip Manikrao Mondhe ,  Shanmugavel Muthiah ,  Surjeet Singh ,  Monika Verma ,  Shashank Kumar Singh

IPC分类号： A61K31/19 ,  C07C62/30

CPC分类号： A61K31/19

摘要： The present invention relates to use of compounds of general formula 1 for anticancerous activity, wherein the said compound being derived semi-synthetically from natural triterpenoic acids known as boswellic acids by the induction of apoptosis thereof cytotoxicity and anti-cancer activity displayed by semi-synthetic analogues of natural triterpenes, known as Boswellic acids. These compounds may be used for the treatment of cancer, alone or in combination with pharmaceutically acceptable or other carriers, displaying cytotoxicity and anti-cancer activity for colon, prostrate, liver, breast, central nervous system (CNS), leukemia and malignancy of other tissues, including ascites and solid tumors. The cancer cell death is mediated by induction of apoptosis and inhibition of cell proliferation at specific doses.

摘要翻译： 本发明涉及通式1的化合物用于抗癌活性的用途，其中所述化合物通过诱导其细胞凋亡的细胞毒性和半合成显示的抗癌活性而被天然三萜烯酸被称为保乳酸半合成衍生 天然三萜类似物，称为乳香酸。 这些化合物可以单独使用或与药学上可接受的或其它载体组合用于治疗癌症，显示对结肠，前列腺癌，肝癌，乳腺癌，中枢神经系统（CNS），白血病和其他恶性肿瘤的细胞毒性和抗癌活性 组织，包括腹水和实体瘤。 癌细胞死亡是通过细胞凋亡的诱导和特定剂量的细胞增殖抑制来介导的。