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    CAPSULES FROM SEPARATED POLYMER SOLUTIONS
    1.
    发明申请
    CAPSULES FROM SEPARATED POLYMER SOLUTIONS 审中-公开
    分离聚合物溶液的胶囊

    公开(公告)号：US20100086664A1

    公开(公告)日：2010-04-08

    申请号：US12514832

    申请日：2007-11-15

    Applicant: Albert Thijs Poortinga ,  Ramona Maria Henricus Prickaerts

    Inventor： Albert Thijs Poortinga ,  Ramona Maria Henricus Prickaerts

    IPC: A23C19/00 ,  A23J1/00 ,  A23G3/00 ,  A23C9/154 ,  A23C21/00

    CPC classification number: A61K9/107 ,  A23C9/1307 ,  A23C19/09 ,  A23C2210/40 ,  A23L27/84 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/1075 ,  A61K9/5089 ,  A23V2200/224 ,  A23V2250/54246 ,  A23V2250/5026 ,  A23V2250/54252 ,  A23V2250/51088

    Abstract: The invention relates to a method of preparing a double emulsion comprising a) preparing an emulsion comprising at least two liquid phases by bringing a first polymer (A) and a second polymer (B) into contact with each other in a solvent, wherein the concentrations of the polymers are chosen such that, upon bringing them into contact, a phase separation occurs, thereby forming drops of a first liquid phase in a second liquid phase, wherein, in the first phase, the weight concentration of the polymer A (CA) is higher and the weight concentration of the polymer B (CB) is lower than the respective concentrations in the second phase; b) dispersing the emulsion in a third liquid phase, which third phase comprises the polymer A in a CA which is higher than in the second phase and the polymer B in a CB which is lower than in the second phase, thereby forming the double emulsion, comprising at least one discontinuous phase (1)—with a relatively high CA and a relatively low CB—enclosed by a surrounding phase (2)—with a relatively low CA and a relatively high CB—which discontinuous and surrounding phase are dispersed in a continuous phase (3)—with a relatively high CA and a relatively low CB; and wherein the solvent in said liquid phases is the same or the solvents are at least, in the absence of the polymers, soluble in one another or completely miscible at 25° C.

    Abstract translation: 本发明涉及一种制备双重乳液的方法，其包括：a）通过使第一聚合物（A）和第二聚合物（B）在溶剂中彼此接触来制备包含至少两个液相的乳液，其中浓度 选择聚合物，使得当它们接触时，发生相分离，从而在第二液相中形成第一液相的液滴，其中在第一相中，聚合物A（CA）的重量浓度 聚合物B（CB）的重量浓度低于第二相中的相应浓度; b）将乳液分散在第三液相中，该第三相包含在高于第二相的CA中的聚合物A和CB中低于第二相的聚合物B，从而形成双重乳液 包括至少一个不连续相（1） - 具有相对较高的CA和相对较低的CB-由周围相（2）包围 - 具有相对较低的CA和相对较高的CB - 该不连续和周围相分散在 连续相（3） - 具有较高的CA和较低的CB; 并且其中所述液相中的溶剂相同或溶剂至少在不存在聚合物的情况下彼此相溶或在25℃完全混溶。

    DOUBLE EMULSION AND METHOD TO PRODUCE SUCH
    3.
    发明申请
    DOUBLE EMULSION AND METHOD TO PRODUCE SUCH 审中-公开
    双重乳液和生产方法

    公开(公告)号：US20110189298A1

    公开(公告)日：2011-08-04

    申请号：US13122084

    申请日：2009-10-01

    Applicant: Hendrik Vos ,  Albert Thijs Poortinga

    Inventor： Hendrik Vos ,  Albert Thijs Poortinga

    IPC: A61K47/08 ,  B01J13/02 ,  A61K9/14 ,  A61K9/107

    CPC classification number: A23P10/30 ,  A23D7/0053 ,  A23L27/72 ,  A23L33/135 ,  A23P10/35 ,  A61K9/113 ,  A61K9/1617

    Abstract: The invention is directed to a method to produce a water-in-oil-in-water (w/o/w) emulsion, comprising: a. preparing a water-in-oil (w/o) emulsion; b. atomizing said w/o emulsion in the presence of a carrier material comprising at least a water soluble matrix material and at least one emulsifier, to form agglomerates; c. dispersing said agglomerates in an aqueous liquid, such as water or an aqueous solution. Also provided is a new instant powder (obtained after step b) that can be used to prepare the w/o/w emulsion. The emulsion of the invention is advantageously suited for the encapsulation of active components.

    Abstract translation: 本发明涉及一种生产水包油包水（w / o / w）乳液的方法，包括：a。 制备油包水（w / o）乳液; b。 在包含至少一种水溶性基质材料和至少一种乳化剂的载体材料的存在下，使所述w / o乳液雾化，以形成附聚物; C。 将所述附聚物分散在水性液体如水或水溶液中。 还提供了可用于制备w / o / w乳液的新的速溶粉末（步骤b之后获得）。 本发明的乳液有利地适用于活性组分的包封。

    MICROENCAPSULATE AND PROCESS FOR THE MANUFACTURE THEREOF
    4.
    发明申请
    MICROENCAPSULATE AND PROCESS FOR THE MANUFACTURE THEREOF 失效
    微生物制剂及其制造方法

    公开(公告)号：US20110171349A1

    公开(公告)日：2011-07-14

    申请号：US13056969

    申请日：2009-07-31

    Applicant: Albert Thijs Poortinga ,  Daniela Oana Trambitas ,  Gerard Willem Hofland

    Inventor： Albert Thijs Poortinga ,  Daniela Oana Trambitas ,  Gerard Willem Hofland

    IPC: A23P1/04

    CPC classification number: A61K9/5089 ,  A61K9/501 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5052 ,  B01J13/043

    Abstract: The present invention relates to a microencapsulate comprising microcapsules having a diameter of 0.1 μm to 25 μm, said microcapsules comprising: —a core particle having a diameter of 90 nm to 23 μm and containing at least 3% of the active component by weight of said core particle; and—a coating that fully envelops the core particle and containing at least 20 wt. % of a hydrophobic polymer selected from cellulosic ethers, cellulosic esters, zein, shellac, gluten, polylactide, hydrophobic starch derivatives, polyvinyl acetate polymers, polymers or copolymers derived from an acrylic acid ester and/or a methacrylic acid ester and combinations thereof; wherein the core particle contains a release trigger component and/or the coating contains a release trigger component, said release trigger component being selected from: —a water-swellable polymer having a water-uptake capacity at 37° C. and pH 7.0 of less than 20 wt. % and a water-uptake capacity at 37° C. and pH 2.0 of at least 50 wt. %; an—an edible salt having a water solubility at 37° C. and a pH of 7.0 of less than 1 mg/ml and a water solubility at 37° C. and a pH of 2.0 of at least 5 mg/ml; The microencapsulate of the present invention does not release the encapsulated active component when incorporated in water-containing foodstuffs, beverages, nutritional compositions or pharmaceutical compositions. Following ingestion, however, the active component is released rapidly.

    Abstract translation: 本发明涉及一种包含直径为0.1μm至25μm的微胶囊的微胶囊，所述微胶囊包括： - 直径为90nm至23μm的核心颗粒，并含有至少3重量％的活性组分 核心颗粒; 和 - 完全包封核心颗粒并含有至少20wt。 选自纤维素醚，纤维素酯，玉米蛋白，虫胶，麸质，聚丙交酯，疏水性淀粉衍生物，聚乙酸乙烯酯聚合物，衍生自丙烯酸酯和/或甲基丙烯酸酯的聚合物或共聚物的疏水性聚合物的％和其组合; 其中所述核心颗粒含有释放触发组分和/或所述涂层含有释放触发组分，所述释放触发组分选自： - 水溶胀性聚合物，其具有37℃的吸水能力和较低的吸水能力 超过20wt。 ％和在37℃和pH 2.0下的吸水能力至少为50wt。 ％; 一种在37℃下具有水溶性，pH7.0小于1mg / ml，水溶解度在37℃，pH为2.0的至少5mg / ml的食用盐; 当掺入含水食品，饮料，营养组合物或药物组合物中时，本发明的微胶囊剂不释放包封的活性成分。 然而，摄入后，活性成分迅速释放。

    ENCAPSULATION SYSTEM
    8.
    发明申请
    ENCAPSULATION SYSTEM 有权
    封装系统

    公开(公告)号：US20150202151A1

    公开(公告)日：2015-07-23

    申请号：US14421174

    申请日：2013-08-19

    Applicant: Albert Thijs Poortinga

    Inventor： Albert Thijs Poortinga

    IPC: A61K9/113 ,  A23L1/00 ,  A61K9/19

    CPC classification number: A61K9/113 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/19 ,  A61K9/5073 ,  B01J13/14 ,  C09B67/0097

    Abstract: The invention pertains to an encapsulation system; in particular a 3-phase system comprising an inner, second and outer phase wherein the second phase is gaseous, and wherein the 3-phase system has a lifetime of at least 3 min and the second phase has a diameter of less than 1 mm. An example of such a system is a stable, small antibubble. Also, the invention pertains to methods of making such 3-phase systems, and to use and methods of use thereof. In particular, 3-phase systems according to the invention are stabilized by surface active particles or molecules, such as for instance colloidal particles. The 3-phase systems of the invention can include a variety of other compounds, and can among others be used in pharmaceutical- or food-based applications. In particular, a 3-phase system according to the invention, such as for example an antibubble, may deliver pharmaceutical compounds.

    Abstract translation: 本发明涉及封装系统; 特别是包括内相，第二和外相的三相系统，其中第二相是气态的，其中三相系统具有至少3分钟的寿命，第二相的直径小于1mm。 这种系统的一个例子是稳定的，小的反泡剂。 此外，本发明涉及制备这种三相体系的方法，以及使用方法和使用方法。 特别地，根据本发明的三相系统由表面活性颗粒或分子（例如胶体颗粒）稳定。 本发明的三相体系可以包括各种其它化合物，并且可以用于基于药物或食品的应用中。 特别地，根据本发明的三相系统，例如抗生素，可以递送药物化合物。

    Method and apparatus for spray drying and powder produced using said method
    9.
    发明授权
    Method and apparatus for spray drying and powder produced using said method 有权
    使用该方法生产喷雾干燥的方法和装置

    公开(公告)号：US08689459B2

    公开(公告)日：2014-04-08

    申请号：US12518139

    申请日：2006-12-07

    Applicant: Albert Thijs Poortinga ,  René Jos Houben

    Inventor： Albert Thijs Poortinga ,  René Jos Houben

    IPC: F26B21/06

    CPC classification number: B01J2/18 ,  B01J2/02

    Abstract: Method for spray drying a high-viscosity fluid product using a spraying device, wherein the method comprises projecting the fluid product out of an outflow opening of the spraying device for obtaining droplets of the fluid product, wherein the spraying device is arranged to cause a pressure drop in the fluid product across the outflow opening which is larger than 15 bar and at least partially drying the droplets in a drying medium, such as air, to become particles.

    Abstract translation: 用于使用喷涂装置喷雾干燥高粘度流体产品的方法，其中所述方法包括将所述流体产物从所述喷射装置的流出开口突出以获得所述流体产品的液滴，其中所述喷射装置被布置成产生压力 流过出口的流体产品落入大于15巴并至少部分干燥干燥介质（如空气）中的液滴成为颗粒。

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