公开(公告)号：US20120098075A1

公开(公告)日：2012-04-26

申请号：US12910783

申请日：2010-10-23

申请人： Alberto Lamagna ,  Pedro Marcelo Julián ,  Pablo Sergio Mandolesi ,  Alfredo Boselli ,  Betiana Lerner ,  Maximiliano Sebastián Pérez ,  Pablo Daniel Pareja Obregón

发明人： Alberto Lamagna ,  Pedro Marcelo Julián ,  Pablo Sergio Mandolesi ,  Alfredo Boselli ,  Betiana Lerner ,  Maximiliano Sebastián Pérez ,  Pablo Daniel Pareja Obregón

IPC分类号： H01L29/02 ,  H01L21/04

CPC分类号： G01N27/4145 ,  G01N27/4146 ,  G01N27/4148

摘要： An integrated electronic device for detecting gases or biological molecules having a microchip comprising integrated electronics manufactured by the CMOS process. The microchip includes a passivation layer. The passivation layer includes one or more windows configured to cover at least one electronic circuit component of the microchip. The one or more windows leave one or more contacts free. The microchip further includes a sensitive covering coupled with said one or more contacts.

摘要翻译： 一种用于检测气体或生物分子的集成电子装置，其具有包括由CMOS工艺制造的集成电子器件的微芯片。 微芯片包括钝化层。 钝化层包括被配置为覆盖微芯片的至少一个电子电路部件的一个或多个窗口。 一个或多个窗口离开一个或多个联系人。 微芯片还包括与所述一个或多个触点耦合的敏感覆盖层。

公开(公告)号：US20120181178A1

公开(公告)日：2012-07-19

申请号：US13316985

申请日：2011-12-12

申请人： Alberto LAMAGNA ,  Maximiliano Sebastián PÉREZ ,  Betiana Lerner ,  Claudio Berli ,  Andrés Felipe ORDONEZ ,  Alfredo BOSELLI ,  Francisco SACCO ,  Elda Maria SALMORAL ,  Andrés KREINER ,  Carlos Alberto RINALDI ,  Carlos LASORSA

发明人： Alberto LAMAGNA ,  Maximiliano Sebastián PÉREZ ,  Betiana Lerner ,  Claudio Berli ,  Andrés Felipe ORDONEZ ,  Alfredo BOSELLI ,  Francisco SACCO ,  Elda Maria SALMORAL ,  Andrés KREINER ,  Carlos Alberto RINALDI ,  Carlos LASORSA

IPC分类号： C25B7/00

CPC分类号： G01N27/4473

摘要： A fluidic device is disclosed for making electrophoresis of molecules. The device has channels of closed geometry and variable powers over time. Migration of molecules is contained within channel of closed geometry, whereby they can circulate again and again, thus separating the molecules at a wide migration distance. The device has an injection system which is a secondary channel which intersects the main channel. An arrangement of electrodes along this main channel connected to a variable voltage source with multiple outlets which regulates the value of the electric power in each electrode, and the frequency at which the same varies from one electrode to another. Thus it is achieved to generate a periodic arrangement of powers along the channel which set the flow of the sample optimizing the separation process. Electrodes can be added for the detection of molecules by measuring the changes in electric resistivity, current or voltage.

摘要翻译： 公开了用于进行分子电泳的流体装置。 该设备具有封闭几何通道和随时间变化的功率。 分子的迁移包含在封闭几何形状的通道内，由此它们可以一次又一次地循环，从而以宽的迁移距离分离分子。 该装置具有与主通道相交的次级通道的注射系统。 沿着该主通道的电极的布置连接到具有多个出口的可变电压源，所述多个出口调节每个电极中的电力值，以及相同的频率从一个电极到另一个电极的频率。 因此，实现沿着通道产生功率的周期布置，其设定样品的流动优化分离过程。 可以通过测量电阻率，电流或电压的变化来添加电极以检测分子。

公开(公告)号：US20120022792A1

公开(公告)日：2012-01-26

申请号：US13166221

申请日：2011-06-22

申请人： Roberto Daniel Zysler ,  Marcelo Vasquez Mansilla ,  Enio Lima, JR. ,  Pablo Gurman ,  Alberto Lamagna

发明人： Roberto Daniel Zysler ,  Marcelo Vasquez Mansilla ,  Enio Lima, JR. ,  Pablo Gurman ,  Alberto Lamagna

IPC分类号： G06F19/00 ,  G01R33/02

CPC分类号： G01R33/1276

摘要： A method of quantization of magnetic nanoparticle absorption in animal tissues includes determination of the number of magnetic nanoparticles absorbed in animal tissues by magnetization measurements. The method is based on the measurement of magnetization versus magnetic field applied of the tissue sample absorbed with the nanoparticles obtaining their saturation magnetization. This magnitude is compared to the saturation magnetization of the same nanoparticles found in the tissue for the determination of the absolute number of magnetic nanoparticles in the animal tissue studied. The method includes preparing the samples for the sample holder, measuring the magnetization vs. applied magnetic field of a known number of magnetic nanoparticles, determining the saturation magnetization of the sample to be studied by measuring the magnetization and calculating the nanoparticle mass in the tissues from the data measured (saturation magnetization of the sample and of calibration of nanoparticles).

摘要翻译： 动物组织中磁性纳米粒子吸收的量化方法包括通过磁化测量确定在动物组织中吸收的磁性纳米颗粒的数量。 该方法基于用纳米颗粒吸收的组织样品施加的磁化强度对磁场的测量，获得其饱和磁化强度。 将该幅度与组织中发现的相同纳米颗粒的饱和磁化强度进行比较，以确定研究的动物组织中磁性纳米颗粒的绝对数。 该方法包括准备样品架的样品，测量已知数量的磁性纳米颗粒的磁化强度与施加的磁场，通过测量磁化强度和计算组织中的纳米颗粒质量来确定要研究的样品的饱和磁化强度 测量的数据（样品的饱和磁化强度和纳米颗粒的校准）。