公开(公告)号：US20060216820A1

公开(公告)日：2006-09-28

申请号：US10542302

申请日：2004-01-14

Applicant: Alberto Perbellini ,  Carlo Ventura ,  Margherita Maioli

Inventor： Alberto Perbellini ,  Carlo Ventura ,  Margherita Maioli

IPC: A61K31/728 ,  C12N5/08 ,  C12N5/04 ,  C08B37/00 ,  C12N5/06

CPC classification number: C12N5/0657 ,  C12N2501/385 ,  C12N2501/905 ,  C12N2506/02

Abstract: The present the invention relates to a new use of retinoic of hyaluronic acid, that exhibit pre-differentiating activity on totipotent stem cells. The invention also relates to a process to differentiate said stem cells and to select molecules capable of modulating the pro-differentiating activity of those esters.

Abstract translation: 本发明涉及透明质酸视黄酸的新用途，其对全能干细胞具有预分化活性。 本发明还涉及区分所述干细胞和选择能够调节那些酯的促分化活性的分子的方法。

公开(公告)号：US20060074048A1

公开(公告)日：2006-04-06

申请号：US10540939

申请日：2003-12-22

Applicant: Alberto Perbellini ,  Danila Coradini

Inventor： Alberto Perbellini ,  Danila Coradini

IPC: A61K31/728 ,  C08B37/00

CPC classification number: C08B37/0072 ,  A61K47/61

Abstract: The present invention relates to mixed esters of hyaluronic acid, wherein the hydroxyl groups are partially esterified with retinoic and butyric acids. These mixed esters are characterized by specific degrees of esterification and by a high ratio between the degree of substitution with butyric acid and retinoic acid. They exhibit a high anti-proliferative activity associated with activation of cell differentiation, with consequent clinical relevance in the treatment of hyper-proliferative pathologies and in particular of solid and systemic tumors.

Abstract translation: 本发明涉及透明质酸的混合酯，其中羟基被视黄酸和丁酸部分酯化。 这些混合酯的特征在于具体的酯化程度和通过与丁酸和视黄酸的取代度之间的高比例。 它们表现出与细胞分化活化相关的高抗增殖活性，因此在治疗高增殖病理特别是固体和全身肿瘤方面具有临床意义。

公开(公告)号：US06140313A

公开(公告)日：2000-10-31

申请号：US308832

申请日：1999-05-25

Applicant: Alberto Perbellini ,  Danila Coradini

Inventor： Alberto Perbellini ,  Danila Coradini

IPC: A61K31/715 ,  A61P19/00 ,  A61P35/00 ,  A61P43/00 ,  C08B37/00 ,  C08B37/08 ,  A61K31/72

CPC classification number: C08B37/0045 ,  C08B37/0024 ,  C08B37/0036 ,  C08B37/0072

Abstract: The present application describes total or partial butyric esters of polysaccharides as novel compounds; the number of hydroxyl groups esterified with butyric residues per each glycosidic monomer is preferably higher than 0.001; the application also describes the process of preparation of said esters, their use in therapy as antiproliferative agents, and pharmaceutical compositions containing them.

Abstract translation: PCT No.PCT / EP97 / 06589 371日期1999年5月25日 102（e）日期1999年5月25日PCT 1997年11月26日PCT公布。 公开号WO98 / 23648 日期1998年6月4日本申请描述了作为新化合物的多糖的全部或部分丁酸酯; 每个糖苷单体用丁基残基酯化的羟基数优选高于0.001; 本申请还描述了所述酯的制备方法，它们在作为抗增殖剂的治疗中的用途，以及含有它们的药物组合物。

公开(公告)号：US06897203B2

公开(公告)日：2005-05-24

申请号：US10483638

申请日：2002-01-16

Applicant: Alessandro Rastrelli ,  Giuliana Miglierini ,  Alberto Perbellini ,  Luca Stucchi

Inventor： Alessandro Rastrelli ,  Giuliana Miglierini ,  Alberto Perbellini ,  Luca Stucchi

IPC: A61K47/36 ,  A61K8/67 ,  A61K8/72 ,  A61K8/73 ,  A61K31/203 ,  A61K31/25 ,  A61K31/715 ,  A61K31/716 ,  A61K31/728 ,  A61P9/00 ,  A61P11/00 ,  A61P17/06 ,  A61P17/16 ,  A61P19/02 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/04 ,  A61Q19/00 ,  C08B37/00 ,  C08B37/08 ,  C08B37/18

CPC classification number: A61K8/671 ,  A61K8/73 ,  A61K31/25 ,  A61K2800/57 ,  A61Q19/00 ,  C08B37/00 ,  C08B37/0024 ,  C08B37/0036 ,  C08B37/006 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075

Abstract: The present invention relates to polysaccharidic esters of retinoic acid, wherein the hydroxyl groups of the monosaccharidic units of the polysaccharide are partially or totally esterified with retinoic acid. A process to obtain these esters is also described. The products according to the present invention can be used in the pharmaceutical and cosmetic field.

Abstract translation: 本发明涉及视黄酸多糖酯，其中多糖的单糖单元的羟基用视黄酸部分或全部酯化。 还描述了获得这些酯的方法。 根据本发明的产品可用于药物和化妆品领域。

公开(公告)号：US5503848A

公开(公告)日：1996-04-02

申请号：US925073

申请日：1992-08-05

Applicant: Alberto Perbellini ,  Gino Toffano ,  Aurelio Romeo

Inventor： Alberto Perbellini ,  Gino Toffano ,  Aurelio Romeo

IPC: A61F11/00 ,  A61K9/00 ,  A61K9/70 ,  A61K31/715 ,  A61K47/36 ,  A61L15/28 ,  A61L15/42 ,  A61L31/04 ,  A61P1/02 ,  A61P17/00 ,  A61P25/02 ,  A61P27/16 ,  C08J9/28 ,  A61K31/725

CPC classification number: C08J9/28 ,  A61L15/28 ,  A61L15/425 ,  A61L31/042 ,  C08J2201/0504 ,  C08J2305/08 ,  Y10S424/07

Abstract: The present invention relates to a new spongy material consisting essentially of hyaluronic acid or its derivatives. The characteristics of the new pharmaceutical preparations consist in assuring high concentrations of active principle for a long period of time, by exploiting the characteristics of slow release of the active principle.The new pharmaceutical preparations can be utilized advantageously in all the numerous situations of microsurgical practice (in particular the ones relating to ear or in odontostomatology), in which it is necessary to use a substance that can be metabolized by the organism and is capable of making easier flap take, reepithelialization of mucous membranes, stabilization of grafts and filling of cavities.The specific use of the new pharmaceutical preparations is particularly important and useful in the various ear pathologies and in the practice of otologic, otoneurosurgical and odontostomatological microsurgery, such as for instance repair of tympanic perforations.

Abstract translation: 本发明涉及基本上由透明质酸或其衍生物组成的新的海绵状物质。 新型药物制剂的特点是通过开发活性成分缓释的特点，长期保证高浓度的活性成分。 新的药物制剂可以有利地用于显微手术实践（特别是涉及耳朵或牙齿病学）的所有许多情况，其中有必要使用可由生物体代谢并且能够制造的物质 更容易的皮瓣，粘膜的再上皮化，移植物的稳定和腔的填充。 新的药物制剂的具体用途在各种耳朵病理学和耳蜗外科手术和牙周病学显微外科学的实践中是特别重要和有用的，例如鼓膜穿孔的修复。