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1.发明授权Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5A receptor modulators 有权四氢吡啶并吡啶和四氢吡啶并嘧啶化合物及其作为C5A受体调节剂的用途公开(公告)号：US09505755B2
公开(公告)日：2016-11-29
申请号：US14455848
申请日：2014-08-08
申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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2.发明授权Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators 有权四氢吡啶 - 吡啶和四氢吡啶 - 嘧啶化合物及其作为C5a受体调节剂的用途公开(公告)号：US08846656B2
公开(公告)日：2014-09-30
申请号：US13553120
申请日：2012-07-19
申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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3.发明申请TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS 有权四氢吡啶并吡啶和四氢吡啶并吡啶化合物及其作为C5A受体调节剂的用途公开(公告)号：US20130184253A1
公开(公告)日：2013-07-18
申请号：US13553120
申请日：2012-07-19
申请人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian Hurley , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
发明人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian Hurley , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20110190323A1
公开(公告)日：2011-08-04
申请号：US13061318
申请日：2009-08-28
申请人： Alec Nathanson Flyer , Hong Myung Lee , Andrew G. Myers , Cristina Montserrat Nieto-Oberhuber , Matthew D. Shair , Chong Si
发明人： Alec Nathanson Flyer , Hong Myung Lee , Andrew G. Myers , Cristina Montserrat Nieto-Oberhuber , Matthew D. Shair , Chong Si
IPC分类号： A61K31/517 , C07D493/08 , C07D495/04 , A61K31/4725 , A61K31/35 , A61P35/00
CPC分类号： C07D493/08 , A61K31/34 , A61K31/4725
摘要： The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.
摘要翻译： 本发明涉及具有以下通式的皮质激素A，J，K和L的类似物：I及其盐，其中R 1，R 2，R 3，R 4，n和m如本文所定义; 制备此类化合物及其中间体的方法; 包含这些化合物的药物组合物; 治疗增殖性疾病的方法; 用于治疗与异常血管发生相关的疾病的方法; 抑制血管发生的方法; 以及制备皮质激素A，J，K和L及其类似物的方法。
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5.发明申请TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS 审中-公开四氢吡啶并吡啶和四氢吡啶并吡啶化合物及其作为C5A受体调节剂的用途公开(公告)号：US20140349995A1
公开(公告)日：2014-11-27
申请号：US14455848
申请日：2014-08-08
申请人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian HURLEY , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
发明人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian HURLEY , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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