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1.发明授权Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5A receptor modulators 有权四氢吡啶并吡啶和四氢吡啶并嘧啶化合物及其作为C5A受体调节剂的用途公开(公告)号：US09505755B2
公开(公告)日：2016-11-29
申请号：US14455848
申请日：2014-08-08
申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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2.发明授权Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators 有权四氢吡啶 - 吡啶和四氢吡啶 - 嘧啶化合物及其作为C5a受体调节剂的用途公开(公告)号：US08846656B2
公开(公告)日：2014-09-30
申请号：US13553120
申请日：2012-07-19
申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US08242125B2
公开(公告)日：2012-08-14
申请号：US12632396
申请日：2009-12-07
申请人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号： C07D403/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K31/404
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号：US08486954B2
公开(公告)日：2013-07-16
申请号：US13613034
申请日：2012-09-13
申请人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号： C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号：US08501756B2
公开(公告)日：2013-08-06
申请号：US13613062
申请日：2012-09-13
申请人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号： C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
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公开(公告)号：US08541432B2
公开(公告)日：2013-09-24
申请号：US13613053
申请日：2012-09-13
申请人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号： C07D487/04 , C07D487/08 , A61K31/404 , A61P27/02
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号：US08492393B2
公开(公告)日：2013-07-23
申请号：US13613019
申请日：2012-09-13
申请人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号： C07D487/04 , C07D487/08 , A61K31/404
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
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公开(公告)号：US20100168082A1
公开(公告)日：2010-07-01
申请号：US12632396
申请日：2009-12-07
申请人： Gerald David Artmann, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人： Gerald David Artmann, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号： A61K31/55 , C07D403/14 , A61K31/506 , A61K31/4439 , C07D413/14 , C07D471/04 , A61K31/519 , C07D487/04 , C07D261/14 , A61K31/42 , A61K31/4155 , C07D403/04
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.
摘要翻译： 本发明涉及式（I）的新型有机化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，例如治疗肿瘤疾病和眼睛新生血管疾病。
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公开(公告)号：US08431584B2
公开(公告)日：2013-04-30
申请号：US13488760
申请日：2012-06-05
申请人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
发明人： Gerald David Artman, III , Jason Matthew Elliott , Nan Ji , Donglei Liu , Fupeng Ma , Nello Mainolfi , Erik Meredith , Karl Miranda , James J. Powers , Chang Rao
IPC分类号： C07D487/04 , C07D487/08 , A61K31/404
CPC分类号： C07D403/12 , A61K31/18 , A61K31/404 , A61K45/06 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K2300/00
摘要： The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumor diseases and ocular neovascular diseases.
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公开(公告)号：US20110092505A1
公开(公告)日：2011-04-21
申请号：US12996901
申请日：2009-06-12
申请人： Robin Burgis , Michael Paul Capparelli , Lucian Dipietro , Gabriel G. Gamber , Charles Francis Jewell, JR. , Erik Meredith , Karl Miranda , Lauren G. Monovich , Chang Rao , Nicolas Soldermann , Taeyoung Yoon , Qingming Zhu
发明人： Robin Burgis , Michael Paul Capparelli , Lucian Dipietro , Gabriel G. Gamber , Charles Francis Jewell, JR. , Erik Meredith , Karl Miranda , Lauren G. Monovich , Chang Rao , Nicolas Soldermann , Taeyoung Yoon , Qingming Zhu
IPC分类号： A61K31/535 , A61K31/4985 , A61K31/501 , A61K31/497 , A61K31/437 , A61K31/4545 , C07D417/14 , C07D487/04 , C07D413/14 , C07D471/04 , C07D401/14 , A61P17/00 , A61P9/00 , A61P35/00 , A61P37/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention provides novel organic compounds of Formula I: methods of use, and pharmaceutical compositions thereof.
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