公开(公告)号：US06454999B1

公开(公告)日：2002-09-24

申请号：US09430244

申请日：1999-10-29

申请人： Mehrdad Farhangnia ,  Alex Leynov ,  Joseph Loeffler ,  Alec A. Piplani ,  Greg Potts ,  Christian Skieller

发明人： Mehrdad Farhangnia ,  Alex Leynov ,  Joseph Loeffler ,  Alec A. Piplani ,  Greg Potts ,  Christian Skieller

IPC分类号： A61M114

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366 ,  Y10S261/28

摘要： An integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood is provided that includes a plurality of partitions disposed within or about the fiber bundle assembly to lengthen the flow path of blood passing through the fiber bundle. Alternatively, or in addition, blood flow paths may be lengthened and oxygenation improved by providing internal recirculation paths within the pump/oxygenator, which also advantageously may be used to reduce blood trauma caused by stagnation nearing moving parts and heat build-up.

摘要翻译： 提供了一种具有旋转的中空纤维束组合的集成血液泵/充氧器，其包含含氧化物和泵血液，其包括设置在纤维束组件内或周围的多个隔板，以延长通过纤维束的血液的流动路径。 或者或另外，可以通过在泵/氧合器内提供内部再循环路径来延长血液流动路径并且改善氧合作用，其也可有利地用于减少由运动部件附近的滞留引起的血液创伤和积热。

公开(公告)号：US07177702B2

公开(公告)日：2007-02-13

申请号：US10799270

申请日：2004-03-12

申请人： Michael P. Wallace ,  Robert J. Garabedian ,  Alex Leynov

发明人： Michael P. Wallace ,  Robert J. Garabedian ,  Alex Leynov

IPC分类号： A61N1/00

CPC分类号： A61N1/0553 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0558

摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force.

摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘膜，与绝缘膜相关联的弹性弹簧元件，以及与绝缘膜相关联的至少一个电极。 弹簧层构造成将绝缘膜推动成扩展的几何形状。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。

公开(公告)号：US06428747B1

公开(公告)日：2002-08-06

申请号：US09430219

申请日：1999-10-29

申请人： Jean-Pierre Dueri ,  Robert Jochim ,  Alex Leynov

发明人： Jean-Pierre Dueri ,  Robert Jochim ,  Alex Leynov

IPC分类号： A61M3700

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1029 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366

摘要： An integrated blood pump, oxygenator and heat exchanger is provided having a rotating hollow fiber bundle assembly. A plurality of vanes arranged along a central shaft of the device increase pressure near the center of the fiber bundle to develop sufficient pressure head to pump the blood through the heat exchanger. In alternative embodiments, the heat exchanger comprises a pleated metal wall, a bundle of non-permeable hollow fibers, or a coiled tub disposed between the rotating hollow fiber bundle and an interior wall of the housing.

摘要翻译： 提供具有旋转的中空纤维束组件的集成血液泵，充氧器和热交换器。 沿着装置的中心轴布置的多个叶片增加了靠近纤维束中心的压力，以形成足够的压力头，以通过热交换器泵送血液。 在替代实施例中，热交换器包括折叠的金属壁，一束不可渗透的中空纤维或设置在旋转的中空纤维束和壳体的内壁之间的盘管。

公开(公告)号：US20050203602A1

公开(公告)日：2005-09-15

申请号：US10799270

申请日：2004-03-12

申请人： Michael Wallace ,  Robert Garabedian ,  Alex Leynov

发明人： Michael Wallace ,  Robert Garabedian ,  Alex Leynov

IPC分类号： A61N1/05

CPC分类号： A61N1/0553 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0558

摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The spring layer is configured to urge that insulative membrane into an expanded geometry. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.

摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘膜，与绝缘膜相关联的弹性弹簧元件，以及与绝缘膜相关联的至少一个电极。 弹簧层构造成将绝缘膜推动成扩展的几何形状。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。 在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

公开(公告)号：US06503450B1

公开(公告)日：2003-01-07

申请号：US09475467

申请日：1999-12-30

申请人： Thomas A. Afzal ,  Jean-Pierre Dueri ,  Alex Leynov ,  Anthony Makarewicz ,  Alec A. Piplani ,  Greg Potts

发明人： Thomas A. Afzal ,  Jean-Pierre Dueri ,  Alex Leynov ,  Anthony Makarewicz ,  Alec A. Piplani ,  Greg Potts

IPC分类号： A61M114

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1029 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366

摘要： Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. An inner member arranged along a central axis of the device accelerates blood entering the fiber bundle to reduce microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to reduce flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements.

摘要翻译： 具有提供含氧化合物和泵血液的旋转中空纤维束组件的集成血液泵/充氧器的改进。 沿着装置的中心轴布置的内部构件加速进入纤维束的血液，以减少微泡产生和血液创伤。 施加在纤维束的纤维元件上的剪切载荷通过添加加强结构而减少，而气体流动路径被配置为减少由于纤维元件的偶尔破裂引起的淹水和氧合效率的损失。