公开(公告)号：US08277476B2

公开(公告)日：2012-10-02

申请号：US10684557

申请日：2003-10-14

申请人： Charles S. Taylor ,  William N. Aldrich ,  Thomas L. Baughman ,  Federico J. Benetti ,  Brian J. Bennett ,  Michael J. Billig ,  Thomas J. Fogarty ,  John J. Frantzen ,  Richard S. Ginn ,  Robert C. Glines ,  Harry L. Green ,  Dwight P. Morejohn ,  Brent Regan ,  Eugene E. Reis ,  Amr Salahieh ,  Ivan Sepetka ,  Benjamin Sherman ,  Christian Skieller ,  Valavanur A. Subramanian ,  Gary B. Weller ,  William F. Witt

发明人： Charles S. Taylor ,  William N. Aldrich ,  Thomas L. Baughman ,  Federico J. Benetti ,  Brian J. Bennett ,  Michael J. Billig ,  Thomas J. Fogarty ,  John J. Frantzen ,  Richard S. Ginn ,  Robert C. Glines ,  Harry L. Green ,  Dwight P. Morejohn ,  Brent Regan ,  Eugene E. Reis ,  Amr Salahieh ,  Ivan Sepetka ,  Benjamin Sherman ,  Christian Skieller ,  Valavanur A. Subramanian ,  Gary B. Weller ,  William F. Witt

IPC分类号： A61M29/00

CPC分类号： A61B17/3421 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/0206 ,  A61B17/0218 ,  A61B17/0642 ,  A61B17/12 ,  A61B17/3423 ,  A61B17/8076 ,  A61B90/00 ,  A61B2017/00243 ,  A61B2017/00539 ,  A61B2017/00703 ,  A61B2017/00858 ,  A61B2017/00991 ,  A61B2017/0243 ,  A61B2017/0648 ,  A61B2017/1139 ,  A61B2017/2825 ,  A61B2017/2913 ,  A61B2017/2929 ,  A61B2017/306 ,  A61B2017/349

摘要： The invention is methods and devices which a surgeon may use to stabilize the beating heart during a surgical procedure on the heart. Pursuant to the invention, a stabilizing device is introduced through an opening in the chest and brought into contact with the beating heart. By contacting the heart with the device and by exerting a stabilizing force on the device, the motion of the heart caused by the contraction of the heart muscles is effectively eliminated such that the heart is stabilized and the site of the surgery moves only minimally if at all. Typically, in separate steps, the surgeon contacts the heart with the stabilizing means, assesses the degree of movement of the anastomosis site, and exerts a force on the stabilizing means such that the contraction of the beating heart causes orgy minimal excess motion at the surgery site. By fixing the position of the stabilizing means in a configuration where the motion of the beating heart is effectively eliminated, the surgeon is able to stabilize the beating heart for the duration of the procedure. The stabilizing means may be attached to a rigid support or may be attached to a semi-rigid support which is rendered motionless mechanically, chemically, or by human intervention. In certain preferred embodiments, the stabilizing means is affixed to a semi-rigid support which is caused to become rigid, by any of a variety of techniques, such that the position of the stabilizing means becomes fixed by the support, and the heart remains substantially motionless for the duration of the procedure.

摘要翻译： 本发明是外科医生可以在心脏手术过程中稳定跳动心脏的方法和装置。 根据本发明，稳定装置通过胸部的开口引入并与打浆心接触。 通过将心脏与装置接触并且通过在装置上施加稳定力，由心脏肌肉收缩引起的心脏的运动被有效地消除，使得心脏稳定，并且手术部位仅在最小程度上移动，如果在 所有。 通常，在单独的步骤中，外科医生将心脏与稳定装置接触，评估吻合部位的移动程度，并对稳定装置施加力，使得跳动心脏的收缩导致手术时的最小过度运动 现场。 通过将稳定装置的位置固定在跳动心脏的运动被有效地消除的构造中，外科医生能够在手术期间稳定跳动的心脏。 稳定装置可以附接到刚性支撑件，或者可以附接到半刚性支撑件，其通过机械，化学方式或通过人为干预使其不动。 在某些优选实施例中，稳定装置通过各种技术中的任一种被固定到半刚性支撑件上，使其变得刚性，使得稳定装置的位置由支撑件固定，并且心脏基本保持 在程序期间不动。

公开(公告)号：US06346077B1

公开(公告)日：2002-02-12

申请号：US08789751

申请日：1997-01-27

申请人： Charles S. Taylor ,  William N. Aldrich ,  Thomas L. Baughman ,  Federico J. Benetti ,  Brian J. Bennett ,  Michael J. Billig ,  Thomas J. Fogarty ,  John J. Frantzen ,  Richard S. Ginn ,  Robert C. Glines ,  Harry L. Green ,  Dwight P. Morejohn ,  Brent Regan ,  Eugene E. Reis ,  Amr Salahieh ,  Ivan Sepetka ,  Benjamin Sherman ,  Christian Skieller ,  Valavanur A. Subramanian ,  Gary B. Weller ,  William F. Witt

发明人： Charles S. Taylor ,  William N. Aldrich ,  Thomas L. Baughman ,  Federico J. Benetti ,  Brian J. Bennett ,  Michael J. Billig ,  Thomas J. Fogarty ,  John J. Frantzen ,  Richard S. Ginn ,  Robert C. Glines ,  Harry L. Green ,  Dwight P. Morejohn ,  Brent Regan ,  Eugene E. Reis ,  Amr Salahieh ,  Ivan Sepetka ,  Benjamin Sherman ,  Christian Skieller ,  Valavanur A. Subramanian ,  Gary B. Weller ,  William F. Witt

IPC分类号： A61B132

CPC分类号： A61B17/0218 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/0206 ,  A61B17/0642 ,  A61B17/12 ,  A61B17/3421 ,  A61B17/3423 ,  A61B90/00 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00703 ,  A61B2017/00858 ,  A61B2017/0243 ,  A61B2017/1139 ,  A61B2017/2825 ,  A61B2017/2913 ,  A61B2017/2929 ,  A61B2017/306 ,  A61B2017/349

摘要： The invention is methods and devices which a surgeon may use to stabilize the beating heart during a surgical procedure on the heart. Pursuant to the invention, a stabilizing device is introduced through an opening in the chest and brought into contact with the beating heart. By contacting the heart with the device and by exerting a stabilizing force on the device, the motion of the heart caused by the contraction of the heart muscles is effectively eliminated such that the heart is stabilized and the site of the surgery moves only minimally if at all. Typically, in separate steps, the surgeon contacts the heart with the stabilizing means, assesses the degree of movement of the anastomosis site, and exerts a force on the stabilizing means such that the contraction of the beating heart causes orgy minimal excess motion at the surgery site. By fixing the position of the stabilizing means in a configuration where the motion of the beating heart is effectively eliminated, the surgeon is able to stabilize the beating heart for the duration of the procedure. The stabilizing means may be attached to a rigid support or may be attached to a semi-rigid support which is rendered motionless mechanically, chemically, or by human intervention. In certain preferred embodiments, the stabilizing means is affixed to a semi-rigid support which is caused to become rigid, by any of a variety of techniques, such that the position of the stabilizing means becomes fixed by the support, and the heart remains substantially motionless for the duration of the procedure.

摘要翻译： 本发明是外科医生可以在心脏手术过程中稳定跳动心脏的方法和装置。 根据本发明，稳定装置通过胸部的开口引入并与打浆心接触。 通过将心脏与装置接触并且通过在装置上施加稳定力，由心脏肌肉收缩引起的心脏的运动被有效地消除，使得心脏稳定，并且手术部位仅在最小程度上移动，如果在 所有。 通常，在单独的步骤中，外科医生将心脏与稳定装置接触，评估吻合部位的移动程度，并对稳定装置施加力，使得跳动心脏的收缩导致手术时的最小过度运动 现场。 通过将稳定装置的位置固定在跳动心脏的运动被有效地消除的构造中，外科医生能够在手术期间稳定跳动的心脏。 稳定装置可以附接到刚性支撑件，或者可以附接到半刚性支撑件，其通过机械，化学方式或通过人为干预使其不动。 在某些优选实施例中，稳定装置通过各种技术中的任一种被固定到半刚性支撑件上，使其变得刚性，使得稳定装置的位置由支撑件固定，并且心脏基本保持 在程序期间不动。

公开(公告)号：US06454999B1

公开(公告)日：2002-09-24

申请号：US09430244

申请日：1999-10-29

申请人： Mehrdad Farhangnia ,  Alex Leynov ,  Joseph Loeffler ,  Alec A. Piplani ,  Greg Potts ,  Christian Skieller

发明人： Mehrdad Farhangnia ,  Alex Leynov ,  Joseph Loeffler ,  Alec A. Piplani ,  Greg Potts ,  Christian Skieller

IPC分类号： A61M114

CPC分类号： F28F21/062 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1025 ,  A61M1/1036 ,  A61M1/1625 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/366 ,  Y10S261/28

摘要： An integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood is provided that includes a plurality of partitions disposed within or about the fiber bundle assembly to lengthen the flow path of blood passing through the fiber bundle. Alternatively, or in addition, blood flow paths may be lengthened and oxygenation improved by providing internal recirculation paths within the pump/oxygenator, which also advantageously may be used to reduce blood trauma caused by stagnation nearing moving parts and heat build-up.

摘要翻译： 提供了一种具有旋转的中空纤维束组合的集成血液泵/充氧器，其包含含氧化物和泵血液，其包括设置在纤维束组件内或周围的多个隔板，以延长通过纤维束的血液的流动路径。 或者或另外，可以通过在泵/氧合器内提供内部再循环路径来延长血液流动路径并且改善氧合作用，其也可有利地用于减少由运动部件附近的滞留引起的血液创伤和积热。

公开(公告)号：US06743169B1

公开(公告)日：2004-06-01

申请号：US09975392

申请日：2001-10-10

申请人： Charles S. Taylor ,  William N. Aldrich ,  Thomas L. Baughman ,  Federico J. Benetti ,  Brian J. Bennett ,  Michael J. Billig ,  Thomas J. Fogarty ,  John J. Frantzen ,  Richard S. Ginn ,  Robert C. Glines ,  Harry L. Green ,  Dwight P. Morejohn ,  Brent Regan ,  Eugene E. Reis ,  Amr Salahieh ,  Ivan Sepetka ,  Benjamin Sherman ,  Christian Skieller ,  Valavanur A. Subramanian ,  Gary B. Weller ,  William F. Witt

发明人： Charles S. Taylor ,  William N. Aldrich ,  Thomas L. Baughman ,  Federico J. Benetti ,  Brian J. Bennett ,  Michael J. Billig ,  Thomas J. Fogarty ,  John J. Frantzen ,  Richard S. Ginn ,  Robert C. Glines ,  Harry L. Green ,  Dwight P. Morejohn ,  Brent Regan ,  Eugene E. Reis ,  Amr Salahieh ,  Ivan Sepetka ,  Benjamin Sherman ,  Christian Skieller ,  Valavanur A. Subramanian ,  Gary B. Weller ,  William F. Witt

IPC分类号： A61B132

CPC分类号： A61B17/3421 ,  A61B17/00234 ,  A61B17/02 ,  A61B17/0206 ,  A61B17/0218 ,  A61B17/0642 ,  A61B17/12 ,  A61B17/3423 ,  A61B17/8076 ,  A61B90/00 ,  A61B2017/00243 ,  A61B2017/00539 ,  A61B2017/00703 ,  A61B2017/00858 ,  A61B2017/00991 ,  A61B2017/0243 ,  A61B2017/0648 ,  A61B2017/1139 ,  A61B2017/2825 ,  A61B2017/2913 ,  A61B2017/2929 ,  A61B2017/306 ,  A61B2017/349

摘要： The invention is methods and devices which a surgeon may use to stabilize the beating heart during a surgical procedure on the heart. Pursuant to the invention, a stabilizing device is introduced through an opening in the chest and brought into contact with the beating heart. By contacting the heart with the device and by exerting a stabilizing force on the device, the motion of the heart caused by the contraction of the heart muscles is effectively eliminated such that the heart is stabilized and the site of the surgery moves only minimally if at all. Typically, in separate steps, the surgeon contacts the heart with the stabilizing means, assesses the degree of movement of the anastomosis site, and exerts a force on the stabilizing means such that the contraction of the beating heart causes orgy minimal excess motion at the surgery site. By fixing the position of the stabilizing means in a configuration where the motion of the beating heart is effectively eliminated, the surgeon is able to stabilize the beating heart for the duration of the procedure. The stabilizing means may be attached to a rigid support or may be attached to a semi-rigid support which is rendered motionless mechanically, chemically, or by human intervention. In certain preferred embodiments, the stabilizing means is affixed to a semi-rigid support which is caused to become rigid, by any of a variety of techniques, such that the position of the stabilizing means becomes fixed by the support, and the heart remains substantially motionless for the duration of the procedure.

公开(公告)号：US5624597A

公开(公告)日：1997-04-29

申请号：US436670

申请日：1995-05-08

申请人： Steven N. Buhl ,  Terri Bogart ,  Tammy Burd ,  Bhaskar Bhayani ,  Christian Skieller ,  Chi-Sou Yu ,  Thuy N. Tang ,  Vladimir E. Ostoich ,  Branko Huc ,  Carol T. Schembri

发明人： Steven N. Buhl ,  Terri Bogart ,  Tammy Burd ,  Bhaskar Bhayani ,  Christian Skieller ,  Chi-Sou Yu ,  Thuy N. Tang ,  Vladimir E. Ostoich ,  Branko Huc ,  Carol T. Schembri

IPC分类号： C12Q1/32 ,  A61K9/16 ,  C12Q1/42 ,  G01N1/10 ,  G01N9/30 ,  G01N21/78 ,  G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/58 ,  G01N33/68 ,  G01N35/00 ,  C09K3/00 ,  G01N31/00

CPC分类号： G01N33/52 ,  A61K9/1694 ,  C12Q1/42 ,  G01N33/491 ,  G01N33/50 ,  G01N33/585 ,  G01N33/68 ,  Y10S436/805 ,  Y10S436/808 ,  Y10T436/10 ,  Y10T436/111666

摘要： The present invention provides lyophilized reagent spheres comprising reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. Also provided are diluents which are conveniently used in such analyzers.

摘要翻译： 本发明提供了冻干试剂球，其包含适于分析生物样品的试剂，特别是离心分析仪中血液样品的分析。 还提供了在这种分析仪中方便使用的稀释剂。