公开(公告)号：US5798113A

公开(公告)日：1998-08-25

申请号：US449524

申请日：1995-05-24

申请人： Keith E. Dionne ,  Dwaine F. Emerich ,  Diane Hoffman ,  Paul R. Sanberg ,  Lisa Christenson ,  Orion D. Hegre ,  David W. Scharp ,  Paul E. Lacy ,  Patrick Aebischer ,  Alfred V. Vasooncellos ,  Michael J. Lysaght ,  Frank T. Gentile

发明人： Keith E. Dionne ,  Dwaine F. Emerich ,  Diane Hoffman ,  Paul R. Sanberg ,  Lisa Christenson ,  Orion D. Hegre ,  David W. Scharp ,  Paul E. Lacy ,  Patrick Aebischer ,  Alfred V. Vasooncellos ,  Michael J. Lysaght ,  Frank T. Gentile

IPC分类号： A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K9/50 ,  A61K35/12 ,  A61K35/30 ,  A61K35/39 ,  A61K38/18 ,  A61K39/395 ,  A61K47/36 ,  A61K48/00 ,  A61L27/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/077 ,  A61K9/14

CPC分类号： A61K9/0092 ,  A61K35/12 ,  A61K35/30 ,  A61K35/39 ,  A61K38/185 ,  A61K48/00 ,  A61K9/0024 ,  A61K9/4816 ,  C12N5/0012 ,  C12N5/0062 ,  C12N5/0614 ,  C12N5/0656 ,  C12N5/0677 ,  A61K2035/126 ,  A61K2035/128 ,  C12N2510/02 ,  Y10S514/814 ,  Y10S514/866

摘要： A method of providing a biologically active molecule or metabolic or immunologic function to a patient, comprising implanting into the body of the patient at least one immunoisolatory vehicle comprising a core comprising a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells dispersed in a biocompatible matrix formed of a hydrogel or extracellular matrix components, said cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to the patient; and an external jacket surrounding said core, said jacket being formed from a thermoplastic or hydrogel, said jacket being free of said cells projecting externally therefrom, said jacket being biocompatible and having a molecular weight cutoff permitting passage of molecules between the patient and the core through said jacket to provide said biologically active product of function.

摘要翻译： 一种向患者提供生物活性分子或代谢或免疫功能的方法，包括将至少一种免疫隔离载体植入患者体内，所述至少一种免疫隔离载体包含含有超过1μl的体积和分散的至少约104个活细胞的核心 在由水凝胶或细胞外基质组分形成的生物相容性基质中，所述细胞能够分泌生物活性产物或为患者提供代谢或免疫功能; 以及围绕所述芯的外部护套，所述护套由热塑性或水凝胶形成，所述护套没有从其外部突出的所述细胞，所述护套是生物相容的并且具有分子量截留允许分子在患者和核之间通过， 所述夹克提供所述生物活性产品的功能。