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    Methods and compositions for generating hematopoietic cells
    3.
    发明授权
    Methods and compositions for generating hematopoietic cells 有权

    公开(公告)号：US11542473B2

    公开(公告)日：2023-01-03

    申请号：US16343617

    申请日：2016-10-21

    申请人： Amniotics AB

    发明人： Shobhit Saxena ,  Roger Emanuel Rönn ,  Niels-Bjarne Woods

    IPC分类号： C12N5/0789

    摘要： Maturation signals provided via cyclic adenosine monophosphate (cAMP)/Exchange proteins activated by cAMP (Epac) signaling during in vitro generation of blood cells from reprogrammed cells or pluripotent stem cells achieve superior function of hematopoietic cells differentiated from stem cells. The cAMP/Epac signaling enables an increased efficiency of production of precursor to blood and to blood cells. These generated blood cells can be utilized for therapeutics, treatments, disease prevention, drug discovery, personalized medicine, regenerative medicine, cell and tissue generation, universal donor banks and related methods and compositions.

    AN APPARATUS FOR FILTERING AMNIOTIC FLUID
    9.
    发明申请
    AN APPARATUS FOR FILTERING AMNIOTIC FLUID 有权

    公开(公告)号：US20220297032A1

    公开(公告)日：2022-09-22

    申请号：US17596770

    申请日：2020-06-17

    申请人： Amniotics AB

    发明人： Jan Talts ,  Niels-Bjarne Woods

    IPC分类号： B01D24/00 ,  A61B10/00 ,  B01D35/30

    摘要： An apparatus for filtering amniotic fluid containing particulate matter and amniotic cells is disclosed, comprising a filter for filtering the particulate matter from the amniotic fluid, a chamber enclosing the filter, wherein the chamber comprises a fluid inlet and a fluid outlet, and an inlet connector arranged to form a sealing connection between the fluid inlet and an amniotic fluid sample source, wherein, in use, the amniotic fluid pass the filter when flowing from the fluid inlet to the fluid outlet, whereby particulate matter is deposited on the filter and the amniotic fluid flows through the fluid outlet containing amniotic cells.