公开(公告)号：US20080269529A1

公开(公告)日：2008-10-30

申请号：US11667381

申请日：2005-11-10

申请人： Johannes Gerardus (Hans) Vries De ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria Vries De ,  Vincent Ritleng ,  Adeline Marie Josephe Voelklin

发明人： Johannes Gerardus (Hans) Vries De ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria Vries De ,  Vincent Ritleng ,  Adeline Marie Josephe Voelklin

IPC分类号： C07F17/00 ,  C07C29/143

CPC分类号： C07F17/02

摘要： The invention relates to an enantiomerically enriched chiral compound comprising a transition metal M, which comprises four, five or six coordinating groups of which at least one pair is linked together to form a bidentate ligand, in which M is directly bound via one single σ-bond to a carbon atom of an optionally substituted and/or optionally fused (hetero)aromatic ring of said bidentate ligand and in which M is directly bound to a nitrogen atom of a primary or secondary amino group of said bidentate ligand, thereby forming a metallacycle between said bidentate ligand and the metal M, said metal M being selected from the metals of groups 8 and 9 of the Periodic Table of the Elements, in particular iron, ruthenium, osmium, cobalt, rhodium, or iridium. The chiral compound can be used as a catalyst, preferably in an asymmetric transfer hydrogenation process. The invention further relates to a process for an asymmetric transfer hydrogenation of a prochiral compound in the presence of a hydrogen donor and the chiral compound of the invention comprising a transition metal chosen from the metals of groups 8, 9 and 10 of the Periodic Table, in particular iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium or platinum as the catalyst.

摘要翻译： 本发明涉及包含过渡金属M的对映异构体富集的手性化合物，其包含四个，五个或六个配位基团，其中至少一对连接在一起形成双齿配体，其中M通过一个单一的σ- 键合到所述二齿配位体的任选取代的和/或任选稠合的（杂）芳族环的碳原子，其中M直接与所述二齿配位体的伯或仲氨基的氮原子结合，由此形成金属环 在所述二齿配体和金属M之间，所述金属M选自元素周期表第8和9族的金属，特别是铁，钌，锇，钴，铑或铱。 手性化合物可以用作催化剂，优选在不对称转移氢化方法中。 本发明还涉及在氢供体和含有选自元素周期表第8,9和10族的金属的过渡金属的本发明的手性化合物的存在下前手性化合物的不对称转移氢化的方法， 特别是铁，钌，锇，钴，铑，铱，镍，钯或铂作为催化剂。

公开(公告)号：US06921731B2

公开(公告)日：2005-07-26

申请号：US10297237

申请日：2001-06-19

申请人： Floris Jacobus Parlevliet ,  Johannes Gerardus Vries De ,  Andreas Hendrikus Maria Vries De

发明人： Floris Jacobus Parlevliet ,  Johannes Gerardus Vries De ,  Andreas Hendrikus Maria Vries De

IPC分类号： B01J38/42 ,  B01J23/96 ,  B01J31/40 ,  B01J38/54 ,  C07B37/04 ,  C07B61/00 ,  B01J20/34 ,  B01J23/44

CPC分类号： B01J31/1616 ,  B01J21/04 ,  B01J21/08 ,  B01J21/18 ,  B01J23/44 ,  B01J23/96 ,  B01J27/13 ,  B01J31/1805 ,  B01J31/2239 ,  B01J31/4038 ,  B01J38/54 ,  B01J2231/4205 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2531/0222 ,  B01J2531/824 ,  C07B37/04 ,  Y02P20/584

摘要： Process for regenerating a Pd catalyst after a homogeneously catalyzed C—C coupling reaction in which the Pd catalyst precipitates, is separated from the reaction mixture and subsequently treated with I2 or Br2. The Pd catalyst can then be used in a subsequent reaction run.Preferably between 1 and 3 mole equivalents of I2 or Br2, relative to the quantity of Pd catalyst is usedThe C—C coupling reaction is preferably carried out in the presence of a support material.The C—C coupling reaction may be for example a Heck reaction, a Suzuki reaction or a cross-coupling reaction.

摘要翻译： 在其中Pd催化剂沉淀的均匀催化的C-C偶联反应后，从反应混合物中分离出Pd催化剂再生方法，随后用I 2或Br 2 N处理。 然后可以在随后的反应运行中使用Pd催化剂。 相对于Pd催化剂的量，优选1〜3摩尔当量的I 2或Br 2 N。CC偶联反应优选在 支撑材料 C-C偶联反应可以是例如Heck反应，Suzuki反应或交叉偶联反应。