公开(公告)号：US10526363B2

公开(公告)日：2020-01-07

申请号：US15503776

申请日：2015-08-14

Applicant: Merck Sharp & Dohme Corp. ,  Merck Sharp & Dohme Limited ,  John Simon Edwards ,  Peter Richard Mullens ,  Edward Cleator ,  Bryon L. Simmons ,  Courtney K. Maguire ,  Jeremy Peter Scott ,  Nobuyoshi Yasuda ,  Yong-Li Zhong ,  Lisa F. Frey ,  Peter G. Dormer ,  Andrew Brunskill ,  Artis Klapars ,  Pu Qian ,  Yi Zhang ,  Baoqiang Wan ,  Eric Ashley

Inventor： John Simon Edwards ,  Peter Richard Mullens ,  Edward Cleator ,  Bryon L. Simmons ,  Courtney K. Maguire ,  Jeremy Peter Scott ,  Nobuyoshi Yasuda ,  Yong-Li Zhong ,  Lisa F. Frey ,  Peter G. Dormer ,  Andrew Brunskill ,  Artis Klapars ,  Pu Qian ,  Yi Zhang ,  Baoqiang Wan ,  Eric Ashley

IPC: C07H19/10 ,  C07F9/58 ,  C07H19/06 ,  C07F9/24 ,  C07F9/6558

Abstract: The present invention is directed to Compounds of Formula (I) and salts thereof, wherein R1, R2, R3 and R4 are defined above herein. The present invention is also directed to uses of the compounds of Formula (I) to add phosphoramidate groups onto organic alcohols.

公开(公告)号：US20180179223A1

公开(公告)日：2018-06-28

申请号：US15578777

申请日：2016-06-03

Applicant: Jingjun Yin ,  Tetsuji Itoh ,  Jianguo Yin ,  Bangping Xiang ,  Kevin R. Campos ,  Alexei Kalinin ,  Zhuqing Liu ,  Melodie Deniz Christensen ,  Kevin M. Belyk ,  Richard J. Varsolona ,  Andrew Brunskill

Inventor： Jingjun Yin ,  Tetsuji Itoh ,  Jianguo Yin ,  Bangping Xiang ,  Kevin R. Campos ,  Alexei Kalinin ,  Zhuqing Liu ,  Melodie Deniz Christensen ,  Kevin M. Belyk ,  Richard J. Varsolona ,  Andrew Brunskill

IPC: C07D498/04 ,  C07F5/02 ,  C07D403/04 ,  B01J31/04

CPC classification number: C07D498/04 ,  B01J31/04 ,  C07D403/04 ,  C07F5/025

Abstract: The present invention is directed to processes for preparing Substituted Tetracyclic Heterocycle Compounds of formula (I): (I) which may be useful as HCV NS5A inhibitors. The present invention is also directed to compounds that may be useful as synthetic intermediates and catalysts in the processes of the invention.

公开(公告)号：US20170275327A1

公开(公告)日：2017-09-28

申请号：US15503776

申请日：2015-08-14

Applicant: John Simon EDWARDS ,  Peter Richard MULLENS ,  Edward CLEATOR ,  Bryon L. SIMMONS ,  Courtney K. MAGUIRE ,  Jeremy Peter SCOTT ,  Nobuyoshi YASUDA ,  Yong ZHONG ,  Lisa F. FREY ,  Peter G. DORMER ,  Andrew BRUNSKILL ,  Artis KLAPARS ,  Eric ASHLEY ,  Pu QIAN ,  Yi ZHANG ,  Baoqiang WAN ,  MERCK SHARP & DOHME CORP. ,  MERCK SHARP & DOHME LIMITED

Inventor： John Edwards ,  Peter Richard Mullens ,  Ed Cleator ,  Bryon L. Simmons ,  Courtney K. Maguire ,  Jeremy Peter Scott ,  Nobuyoshi Yasuda ,  Yong-Li Zhong ,  Lisa F. Frey ,  Peter G. Dormer ,  Andrew Brunskill ,  Artis Klapars ,  Puneet Qian ,  Yi Zhang ,  Baoqiang Wan

IPC: C07H19/10 ,  C07F9/24 ,  C07F9/58

CPC classification number: C07H19/10 ,  C07F9/242 ,  C07F9/2458 ,  C07F9/2487 ,  C07F9/58 ,  C07F9/65586 ,  C07H19/06

Abstract: The present invention is directed to Compounds of Formula (I) and salts thereof, wherein R1, R2, R3 and R4 are defined above herein. The present invention is also directed to uses of the compounds of Formula (I) to add phosphoramidate groups onto organic alcohols.