Characterization of chromosomal inversions using anti-parallel probes
    2.
    发明授权
    Characterization of chromosomal inversions using anti-parallel probes 有权
    使用反平行探针表征染色体反转

    公开(公告)号:US09090935B2

    公开(公告)日:2015-07-28

    申请号:US13270575

    申请日:2011-10-11

    Applicant: F. Andrew Ray

    Inventor: F. Andrew Ray

    CPC classification number: C12Q1/6841 C12Q1/6827 C12Q2537/143

    Abstract: A method for the characterization of chromosomal inversions using anti-parallel probes is described. Reporter species are attached to oligonucleotide strands designed such that they may hybridize to portions of only one of a pair of single-stranded sister chromatids which may be prepared by the CO-FISH procedure. If an inversion has occurred, these marker probes will be detected on the second sister chromatid at the same location as the inversion on the first chromatid. Further, one or more reporter species are replaced with anti-parallel probes that hybridize at known locations along the second sister chromatid such that the position and size of the inversion may be identified/estimated.

    Abstract translation: 描述了使用反平行探针表征染色体反转的方法。 报道物种与设计成可以通过CO-FISH程序制备的一对单链姊妹染色单体中仅一个部分杂交的寡核苷酸链连接。 如果发生反转,则在与第一染色单体上的反转相同的位置处,将在第二姐妹染色单体上检测到这些标记探针。 此外,一个或多个报告物种被替换为反平行探针,其在沿着第二姐妹染色单体的已知位置处杂交,使得可以鉴定/估计反转的位置和大小。

    Hardware based memory scrubbing
    4.
    发明授权
    Hardware based memory scrubbing 有权
    基于硬件的内存擦除

    公开(公告)号:US08307259B2

    公开(公告)日:2012-11-06

    申请号:US12319266

    申请日:2009-01-05

    CPC classification number: G06F11/106 G11C29/52 G11C2029/0409

    Abstract: This application relates to hardware based memory scrubbing. One disclosed embodiment may comprise a system that includes an engine, implemented in hardware, configured to initiate a request for data residing in associated memory. An error system is configured to detect errors in data that has been read from associated memory in response to the request for the data, the error system maintaining a log of entries corresponding to errors detected by the error system. An identifier is associated with each of the entries in the log that result from the request initiated by the engine to differentiate from other entries in the log.

    Abstract translation: 本应用程序涉及基于硬件的内存擦除。 一个公开的实施例可以包括系统,其包括以硬件实现的引擎,被配置为发起对驻留在相关联的存储器中的数据的请求。 错误系统被配置为响应于对数据的请求来检测已经从相关联的存储器读取的数据中的错误,错误系统维护对应于由错误系统检测到的错误的条目的日志。 标识符与日志中由引擎发起的请求相关联的每个条目相关联,以区分日志中的其他条目。

    Hardware based memory scrubbing
    5.
    发明申请
    Hardware based memory scrubbing 有权
    基于硬件的内存擦除

    公开(公告)号:US20090125788A1

    公开(公告)日:2009-05-14

    申请号:US12319266

    申请日:2009-01-05

    CPC classification number: G06F11/106 G11C29/52 G11C2029/0409

    Abstract: This application relates to hardware based memory scrubbing. One disclosed embodiment may comprise a system that includes an engine, implemented in hardware, configured to initiate a request for data residing in associated memory. An error system is configured to detect errors in data that has been read from associated memory in response to the request for the data, the error system maintaining a log of entries corresponding to errors detected by the error system. An identifier is associated with each of the entries in the log that result from the request initiated by the engine to differentiate from other entries in the log.

    Abstract translation: 本应用程序涉及基于硬件的内存擦除。 一个公开的实施例可以包括系统,其包括以硬件实现的引擎,被配置为发起对驻留在相关联的存储器中的数据的请求。 错误系统被配置为响应于对数据的请求来检测已经从相关联的存储器读取的数据中的错误,错误系统维护对应于由错误系统检测到的错误的条目的日志。 标识符与日志中由引擎发起的请求相关联的每个条目相关联,以区分日志中的其他条目。

    Communication device with image transmission operation and method thereof
    6.
    发明申请
    Communication device with image transmission operation and method thereof 审中-公开
    具有图像传输操作的通信设备及其方法

    公开(公告)号:US20060061662A1

    公开(公告)日:2006-03-23

    申请号:US10945185

    申请日:2004-09-20

    Applicant: Andrew Ray

    Inventor: Andrew Ray

    Abstract: A communication device (100, 200) is adapted to participate in a primary communication on a communication channel with at least one other communication device (250); and simultaneously transmit an image to the at least one other communication device (250) or and alternative communication device using the communication channel or an alternative communication channel.

    Abstract translation: 通信设备(100,200)适于参与与至少一个其他通信设备(250)的通信信道上的主要通信; 并且同时将图像发送到至少一个其他通信设备(250),或者使用所述通信信道或替代通信信道来发送替代通信设备。

    METHOD OF CORRECTION FOR WAFER CRYSTAL CUT ERROR IN SEMICONDUCTOR PROCESSING
    7.
    发明申请
    METHOD OF CORRECTION FOR WAFER CRYSTAL CUT ERROR IN SEMICONDUCTOR PROCESSING 失效
    半导体处理中晶体切割误差校正方法

    公开(公告)号:US20050161619A1

    公开(公告)日:2005-07-28

    申请号:US11006840

    申请日:2004-12-08

    Applicant: Andrew Ray

    Inventor: Andrew Ray

    Abstract: The present invention is directed to accounting for crystal cut error data in ion implantation systems, thereby facilitating more accurate ion implantation. One or more aspects of the invention also consider possible shadowing effects that can result from features formed on the surface of a wafer being doped. According to one or more aspects of the invention, crystal cut error data and optionally feature data also are periodically fed forward in one or more ion implantation stages or systems to ascertain how to re-orient the ion beam with respect to the workpiece to achieve desired implantation results.

    Abstract translation: 本发明旨在说明离子注入系统中的晶体切割误差数据,从而促进更精确的离子注入。 本发明的一个或多个方面还考虑可能由在被掺杂的晶片的表面上形成的特征产生的阴影效应。 根据本发明的一个或多个方面,晶体切割误差数据和任选的特征数据也在一个或多个离子注入阶段或系统中周期性地向前馈送,以确定如何相对于工件重新定向离子束以实现期望的 植入结果。

    Electromicroinjection of particles into living cells
    8.
    发明授权
    Electromicroinjection of particles into living cells 失效
    将微粒体注入活细胞

    公开(公告)号:US4784737A

    公开(公告)日:1988-11-15

    申请号:US853823

    申请日:1986-04-18

    CPC classification number: C12N15/89 A61N1/306 C12M35/02 C12N13/00

    Abstract: Method and apparatus for introducing particles into living cells. Fluorescently-stained human chromosomes are introduced into cultured, mitotic Chinese hamster cells using electromicroinjection. The recipient cells frequently survived the physiological perturbation imposed by a successful chromosome injection. Successfully injected recipient cells maintained viability as evidenced by their ability to be expanded.The technique relies on the surface charge of fluorescently stained chromosomes and their ability to be attracted and repelled to and from the tip of a micropipette. The apparatus includes a micropipette having a tip suitable for piercing the membrane of a target cell and an electrode inserted into the lumen thereof. The target cells and suspended particles are located in an electrically conducted solution, and the lumen of the micropipette is filled with an electrically conducting solution which contacts the electrode located therein. A second electrode is also located in the conducting solution containing the target cells and particles. Voltages applied to the electrode within the micropipette attract the particles to the region of the tip thereof. The particles adhere to the surface of the micropipette with sufficient force that insertion of the micropipette tip and attached particle through the membrane of a target cell will not dislodge the particle. By applying a voltage having the opposite polarity of the attraction voltage, the particles are expelled from the micropipette to which is then withdrawn from the cell body.

    Abstract translation: 将颗粒引入活细胞的方法和装置。 荧光染色的人类染色体使用电喷雾引入培养的有丝分裂的中国仓鼠细胞。 受体细胞经常由成功的染色体注射施加的生理扰动中存活。 成功注射受体细胞保持活力,这是由于其扩展能力所证明。 该技术依赖于荧光染色体的表面电荷及其吸附和排斥到微量移液管尖端的能力。 该装置包括具有尖端的微量移液管,该尖端适于刺穿靶细胞的膜和插入其内腔中的电极。 靶细胞和悬浮颗粒位于导电溶液中,并且微量移液管的内腔填充有与位于其中的电极接触的导电溶液。 第二电极也位于含有靶细胞和颗粒的导电溶液中。 施加到微量移液管内的电极的电压将颗粒吸引到其尖端的区域。 颗粒以足够的力粘附到微量吸管的表面,使得微量吸头和附着的颗粒通过靶细胞的膜插入不会移除颗粒。 通过施加具有与吸引电压相反的极性的电压,颗粒从微量移液管排出,然后将其从细胞体中取出。

    CLEANING PRESSURE REDUCTION THROUGH BLOWPIPES
    9.
    发明申请
    CLEANING PRESSURE REDUCTION THROUGH BLOWPIPES 失效
    通过吹风机清洁压力减少

    公开(公告)号:US20100275776A1

    公开(公告)日:2010-11-04

    申请号:US12434046

    申请日:2009-05-01

    Applicant: Andrew Ray

    Inventor: Andrew Ray

    CPC classification number: B01D46/0068 B01D46/04 B01D46/42

    Abstract: A system for cleaning at least one filter in a baghouse and an associated method for providing the system. The at least one filter separate a dirty gas chamber from a clean gas chamber, and filters at least one substance from a gas. The system includes a supply of compressed air and a blowpipe to direct the air at the at least one filter to dislodge a collected amount of the at least one substance from the at least one filter. The blowpipe has a cross-sectional flow area through which the compressed air flows. A valve controls provision of the compressed air. The valve has a cross-sectional flow area though which the compressed gas flows. The cross-sectional area of the valve is smaller than the cross-sectional area of the blowpipe to provide for air pressure at the valve to be greater than air pressure at the blowpipe.

    Abstract translation: 用于清洁袋式清洁器中的至少一个过滤器的系统和用于提供系统的相关方法。 至少一个过滤器将脏气体室与清洁气体室分离,并从气体中过滤至少一种物质。 该系统包括供应压缩空气和吹管,以引导至少一个过滤器处的空气以从所述至少一个过滤器中移走所收集的至少一种物质的量。 吹气管具有压缩空气流过的横截面流动区域。 阀控制压缩空气的供应。 该阀具有压缩气体流过的横截面流动面积。 阀的横截面面积小于吹管的横截面积,以使阀处的空气压力大于吹管处的空气压力。

    DETECTION OF CHROMOSOMAL INVERSIONS
    10.
    发明申请
    DETECTION OF CHROMOSOMAL INVERSIONS 有权
    检测染色体反应

    公开(公告)号:US20100062434A1

    公开(公告)日:2010-03-11

    申请号:US12375816

    申请日:2007-09-20

    CPC classification number: C12Q1/6827 C12Q1/6841 C12Q2565/601

    Abstract: A method and a kit for the identification of chromosomal inversions is described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are attached to oligonucleotide strands designed such that they may hybridize to portions of only one of a pair of single-stranded sister chromatids prepared by the CO-FISH procedure, as an example. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid.

    Abstract translation: 描述了用于鉴定染色体反转的方法和试剂盒。 染色体反转难以检测,除非它们相当大。 改进的检测染色体反转能力对于诸如癌症和出生缺陷的许多医学应用是重要的,例如。 报道物种连接到设计为使得它们可以与仅通过CO-FISH程序制备的一对单链姊妹染色单体中的仅一个部分杂交的寡核苷酸链上作为例子。 如果发生反转,则在与第一染色单体上的反转相同位置的姐妹染色单体上将检测到这些标记探针。

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