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公开(公告)号：US09127291B2
公开(公告)日：2015-09-08
申请号：US13969799
申请日：2013-08-19
Applicant: Kiminobu Sugaya , Angel Alvarez , Amelia Marutle
Inventor： Kiminobu Sugaya , Angel Alvarez , Amelia Marutle
CPC classification number: C12N15/85 , C12N5/0657 , C12N15/87 , C12N2501/40 , C12N2506/08 , C12N2510/00
Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.
Abstract translation: 通过用核酸序列转染来描述偏倚细胞，例如有效和多能干细胞，以分化为期望的末期细胞或具有期望的末期细胞特征的细胞。 在具体的实施方案中，用含有转录因子发育对照基因的同源框家族中的基因的载体转染人神经干细胞，并且这导致得到的转化细胞或其后代的较大比例分化成期望的末期细胞或 具有期望的末期电池的特性的电池。
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公开(公告)号：US08853382B2
公开(公告)日：2014-10-07
申请号：US13814484
申请日：2011-08-04
Applicant: Lennart Hammarström , Harold Marcotte , Miguel Angel Alvarez , Maria Cruz Martin
Inventor： Lennart Hammarström , Harold Marcotte , Miguel Angel Alvarez , Maria Cruz Martin
CPC classification number: C12N15/746 , A61K35/747 , A61K2035/115 , A61K2039/505 , C07K16/2821 , C07K16/2845 , C07K2317/14 , C07K2317/20 , C07K2317/569 , C07K2317/622 , Y02A50/386 , Y02A50/388 , Y02A50/401 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/466 , Y02A50/471 , Y02A50/48 , Y02A50/484
Abstract: Described herein are methods and compositions for expressing an antibody or a fragment thereof in a microorganism and use of the microorganism to treat or prevent a pathogenic infection in a mammal.
Abstract translation: 本文描述了用于在微生物中表达抗体或其片段的方法和组合物，以及微生物用于治疗或预防哺乳动物的病原体感染的用途。
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公开(公告)号：US08105832B1
公开(公告)日：2012-01-31
申请号：US12176647
申请日：2008-07-21
Applicant: Kimonobu Sugaya , Angel Alvarez
Inventor： Kimonobu Sugaya , Angel Alvarez
IPC: C12N5/07 , C12N5/0775 , C12N5/02
CPC classification number: C12N5/0663 , C12N2500/80 , C12N2506/00
Abstract: The invention provides a method of up-regulating genes in cultured human bone marrow mesenchymal stem cells, the method comprising culturing the stem cells in a nutrient medium together with cells from a limb of a limb-regenerating animal. In the method, the limb-regenerating animal is preferably a species of the family Polychrotidae. Another method of the invention provides for up-regulating genes maintaining pluripotency and proliferation in cultured human bone marrow mesenchymal stem cells by culturing the stem cells in a nutrient medium together with mouse embryonic stem cells.
Abstract translation: 本发明提供了培养的人骨髓间充质干细胞中上调基因的方法，所述方法包括将营养培养基中的干细胞与来自肢体再生动物的肢体的细胞一起培养。 在该方法中，肢体再生动物优选为多毛科（Polychrotidae）的种类。 本发明的另一种方法通过在营养培养基中与小鼠胚胎干细胞一起培养干细胞来提供培养的人骨髓间充质干细胞中保持多能性和增殖的上调基因。
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公开(公告)号：US20110313229A1
公开(公告)日：2011-12-22
申请号：US13055542
申请日：2009-07-24
Applicant: Kiminobu Sugaya , Angel Alvarez , Sergey Bushnev , Nicholas G. Avgeropoulos
Inventor： Kiminobu Sugaya , Angel Alvarez , Sergey Bushnev , Nicholas G. Avgeropoulos
IPC: A61N5/00 , C12N5/095 , A61P37/04 , A61K31/713 , A61P35/00 , A61K39/00 , C12N5/0784
CPC classification number: A61K39/0011 , A61K2039/5154 , A61K2039/5158
Abstract: Disclosed herein are new immunotherapy methods that involve the isolation of cancer stem cells from tumor tissue and use of the cells either directly or indirectly through proteins or other factors associated with the cells to activate antigen presenting cells. The activated antigen presenting cells are useful as a therapy against the tumor. Also disclosed herein are novel methods of isolating and characterizing cancer stem cells and producing individual cancer stem cell lines. Dendritic cell lines are also disclosed herein.
Abstract translation: 本文公开了涉及从肿瘤组织分离癌干细胞和通过蛋白质或与细胞相关的其它因子直接或间接使用细胞以激活抗原呈递细胞的新的免疫治疗方法。 活化的抗原呈递细胞可用作对肿瘤的治疗。 本文还公开了分离和表征癌症干细胞并产生个体癌症干细胞系的新方法。 树突状细胞系也在本文中公开。
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5.发明申请Medical Components Having Coated Surfaces Exhibiting Low Friction and Methods of Reducing Sticktion 审中-公开具有低摩擦涂层表面的医疗部件和减少粘贴的方法公开(公告)号：US20080071228A1
公开(公告)日：2008-03-20
申请号：US11855437
申请日：2007-09-14
Applicant: Shang-Ren Wu , Angel Alvarez , Stephen Simmons
Inventor： Shang-Ren Wu , Angel Alvarez , Stephen Simmons
CPC classification number: A61L31/10 , A61L31/14 , A61M5/31513 , A61M2005/3131 , A61M2207/00
Abstract: This invention relates to components useful for medical articles, such as a syringe assembly, having sliding surface(s) coated with a composition including organopolysiloxane(s), the coating being adhered to the surface(s) of the component by crosslinking induced by oxidative treatment and irradiation with an isotope, electron beam or ultraviolet radiation or heat treatment; medical articles including the same; methods to reduce static and kinetic friction between slidable surfaces; and articles of low friction prepared thereby.
Abstract translation: 本发明涉及可用于医疗制品的组件，例如注射器组件，其具有涂覆有包含有机聚硅氧烷的组合物的滑动表面，所述涂层通过氧化性诱导的交联粘附到组分的表面 处理和照射同位素，电子束或紫外线辐射或热处理; 医疗用品相同; 降低滑动表面之间静电和动摩擦的方法; 并由此制备低摩擦制品。
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Patent Agency Ranking
公开(公告)号：US06711818B2
公开(公告)日：2004-03-30
申请号：US10031623
申请日：2002-01-16
Applicant: Angel Alvarez-Mendez , Volker Steude
Inventor： Angel Alvarez-Mendez , Volker Steude
IPC: B23B100
CPC classification number: F16D3/223 , B23D1/28 , F16D2003/22303 , F16D2250/00 , Y10T29/49691 , Y10T82/10 , Y10T82/122 , Y10T409/30
Abstract: A procedure to machine openings in work pieces which provides two cutting blades (11, 12), defining a cutting blade axis, adjacent to a work piece in which an opening is to be machined, the opening defining a distance between two oppositely positioned opening edges and defining an opening axis. The opening axis and the cutting blade axis are inclined at an acute angle (&agr;) to one another in a way that the distance between the cutting blades parallel to the opening axis (9) is equal to the required distance between the opening edges. With the increasing wear of the cutting blades, the inclination angle is reduced so that the cutting blade distance parallel to the opening axis continues to correspond to the required distance of the opening edges.
Abstract translation: 一种用于加工工件中的开口的程序，其提供两个切割刀片（11,12），其限定切割刀片轴线，邻近待加工的开口的工件，所述开口限定两个相对定位的开口边缘之间的距离 并限定开放轴。 开口轴线和切割刀片轴线以与切割轴线（9）平行的切割刀片之间的距离等于开口边缘之间所需的距离的方式相互倾斜成锐角（α）。 随着切割刀片的磨损增加，倾斜角度减小，使得平行于打开轴线的切割刀片距离继续对应于开口边缘的所需距离。
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公开(公告)号：US08759090B2
公开(公告)日：2014-06-24
申请号：US11554059
申请日：2006-10-30
Applicant: Kiminobu Sugaya , Angel Alvarez
Inventor： Kiminobu Sugaya , Angel Alvarez
CPC classification number: G06Q50/22
Abstract: Disclosed herein are methods for producing a stem cell bank and providing stem cell samples for purchase or use. Also, provided herein are embodiments relating to a stem cell bank and stem cell banking system.
Abstract translation: 本文公开了生产干细胞库并提供用于购买或使用的干细胞样品的方法。 此外，本文提供了涉及干细胞库和干细胞银行系统的实施方案。
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8.发明授权Mesenchymal stem cells with increased developmental potency by expressing Nanog 有权间充质干细胞通过表达Nanog具有增加的发育潜能公开(公告)号：US08361791B2
公开(公告)日：2013-01-29
申请号：US13483807
申请日：2012-05-30
Applicant: Kiminobu Sugaya , Angel Alvarez
Inventor： Kiminobu Sugaya , Angel Alvarez
CPC classification number: C12N5/0606 , C12N5/0657 , C12N5/0663 , C12N2501/605 , C12N2506/1346 , C12N2510/00
Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.
Abstract translation: 本文公开了用于从较不发育有效的细胞产生更具发展潜力的细胞的方法和材料。 本文具体举例说明的方法包括将可表达的去分化多核苷酸序列引入较不发育有效的细胞中，其中转染的较少的发育有效的细胞变成能够区分其原始血统或不同的发育有效细胞的较不发育有效的细胞的更具发展潜力的细胞 血统。
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公开(公告)号：US08292224B1
公开(公告)日：2012-10-23
申请号：US12354567
申请日：2009-01-15
Applicant: Sam J. Ahad , Miguel Angel Alvarez-Torres
Inventor： Sam J. Ahad , Miguel Angel Alvarez-Torres
CPC classification number: B64D11/0696 , B61D33/0057
Abstract: An improved seating apparatus for an aircraft includes a seat assembly and a quick install track fitting assembly for securing the seat assembly to the aircraft. In a preferred embodiment, the quick install track fitting assembly is made up of a track fitting body for insertion into an aircraft seat track and a manual lever that is pivotably attached to the track fitting body. The manual lever has a lever release position and a lever lock position. A force bearing plunger is movably attached to the manual lever for transferring force to the aircraft seat track. The force bearing plunger has a track release position and a track lock position, wherein both positions correspond to the lever release and lever lock positions of the manual lever. A lock may also be provided for maintaining the plunger in the track lock position when the manual lever is in the lever lock position. The quick install aircraft track fitting may further include a spring loaded secondary plunger to help locate and provide a secondary lock for securing the seat assembly into a proper position within the aircraft seat track. Moreover, the quick install track fitting may further include an anti-rattle feature that urges the force bearing plunger against the top of the seat track.
Abstract translation: 用于飞机的改进的座椅装置包括座椅组件和用于将座椅组件固定到飞行器的快速安装轨道配件组件。 在优选实施例中，快速安装轨道配件组件由用于插入飞行器座椅轨道的轨道配件主体和可枢转地附接到轨道配件主体的手动杆组成。 手动杆具有杠杆释放位置和杠杆锁定位置。 力轴承柱塞可移动地附接到手动杆以将力传递到飞行器座椅轨道。 力轴承柱塞具有轨道释放位置和轨道锁定位置，其中两个位置对应于手柄的杠杆释放和杠杆锁定位置。 还可以设置锁定件，以在手动杆处于杠杆锁定位置时将柱塞保持在轨道锁定位置。 快速安装飞机轨道配件还可以包括弹簧加载的次级柱塞，以帮助定位和提供用于将座椅组件固定到飞机座椅轨道内的适当位置的辅助锁。 此外，快速安装轨道配件可以进一步包括一个抵抗座椅轨道的顶部推动力轴承柱塞的防撞击特征。
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公开(公告)号：US20120238015A1
公开(公告)日：2012-09-20
申请号：US13483807
申请日：2012-05-30
Applicant: Kiminobu Sugaya , Angel Alvarez
Inventor： Kiminobu Sugaya , Angel Alvarez
IPC: C12N5/10
CPC classification number: C12N5/0606 , C12N5/0657 , C12N5/0663 , C12N2501/605 , C12N2506/1346 , C12N2510/00
Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.
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