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    Method for producing a stable polymerized hemoglobin blood-substitute
    1.
    发明授权
    Method for producing a stable polymerized hemoglobin blood-substitute 失效
    生产稳定聚合血红蛋白血液替代品的方法

    公开(公告)号：US5955581A

    公开(公告)日：1999-09-21

    申请号：US484775

    申请日：1995-06-07

    申请人： Carl W. Rausch ,  Maria S. Gawryl ,  Robert A. Houtchens ,  Anthony J. Laccetti ,  William R. Light

    发明人： Carl W. Rausch ,  Maria S. Gawryl ,  Robert A. Houtchens ,  Anthony J. Laccetti ,  William R. Light

    IPC分类号： A01N1/02 ,  A61J1/00 ,  A61J1/05 ,  A61K38/00 ,  A61M1/36 ,  B32B15/08 ,  B32B27/08 ,  C07K14/805

    CPC分类号： A01N1/02 ,  A01N1/0221 ,  A01N1/0226 ,  B32B15/08 ,  B32B27/08 ,  C07K14/805 ,  A61J1/05 ,  A61K38/00 ,  A61M1/3693 ,  A61M2202/0433

    摘要： A method for producing a stable polymerized hemoglobin blood-substitute from blood. The method of this invention includes mixing blood with an anticoagulant to form a blood solution, washing the red blood cells in the blood solution and then separating the washed red blood cells from the white blood cells. This method also includes disrupting the red blood cells to release hemoglobin and form a hemoglobin solution, which is then treated by high performance liquid chromatography to form a hemoglobin eluate. The hemoglobin eluate is then deoxygenated, contacted with a first sulfhydryl compound to form an oxidation-stabilized deoxygenated hemoglobin solution, and mixed with a cross-linking agent to form a polymerization reaction mixture, which is then polymerized. The polymerized hemoglobin solution is then diafiltered with a physiologic solution and with a sulfhydryl compound, whereby the polymerized hemoglobin solution is made physiologically acceptable, and whereby the sulfhydryl compound scavenges oxygen, to form a stable polymerized hemoglobin blood-substitute.

    摘要翻译： 从血液制备稳定的聚合血红蛋白血液代用品的方法。 本发明的方法包括将血液与抗凝血剂混合以形成血液溶液，洗涤血液中的红细胞，然后从白细胞中分离洗涤的红细胞。 该方法还包括破坏红细胞以释放血红蛋白并形成血红蛋白溶液，然后通过高效液相色谱法处理以形成血红蛋白洗脱液。 然后将血红蛋白洗脱液脱氧，与第一巯基化合物接触以形成氧化稳定的脱氧血红蛋白溶液，并与交联剂混合以形成聚合反应混合物，然后将其聚合。 然后将聚合的血红蛋白溶液用生理溶液和巯基化合物进行渗滤，由此将聚合的血红蛋白溶液制成生理学上可接受的，由此巯基化合物清除氧气，形成稳定的聚合血红蛋白血液替代品。

    Stable polymerized hemoglobin and use thereof
    2.
    发明授权
    Stable polymerized hemoglobin and use thereof 失效
    稳定的聚合血红蛋白及其用途

    公开(公告)号：US5895810A

    公开(公告)日：1999-04-20

    申请号：US487288

    申请日：1995-06-07

    申请人： William R. Light ,  Maria S. Gawryl ,  Anthony J. Laccetti

    发明人： William R. Light ,  Maria S. Gawryl ,  Anthony J. Laccetti

    IPC分类号： A01N1/02 ,  A61J1/00 ,  A61J1/05 ,  A61K38/00 ,  B32B15/08 ,  B32B27/08 ,  C07K14/805

    CPC分类号： C07K14/805 ,  A01N1/02 ,  A01N1/0263 ,  B32B15/08 ,  B32B27/08 ,  A61J1/05 ,  A61K38/00

    摘要： The present invention relates to a composition of matter comprising a stable polymerized hemoglobin solution, useful for forming blood-substitutes, and to a method for forming said stable polymerized hemoglobin solution. The stable polymerized hemoglobin solution, and derived blood-substitutes, of this invention comprise polymerized hemoglobin and a sulfhydryl compound, both in solution, wherein the sulfhydryl compound stabilizes the polymerized hemoglobin.The method of this invention comprises deoxygenating hemoglobin in a hemoglobin solution and then mixing the deoxygenated hemoglobin with a sulfhydryl compound to form an oxidation-stabilized, deoxygenated hemoglobin solution. Subsequently, the oxidation-stabilized deoxygenated hemoglobin solution is mixed with a cross-linking agent to form a polymerization reaction mixture, which is then polymerized to form a stable polymerized hemoglobin solution.

    摘要翻译： 本发明涉及包含可用于形成血液代用品的稳定聚合血红蛋白溶液的物质组合物以及形成所述稳定聚合血红蛋白溶液的方法。 本发明的稳定的聚合血红蛋白溶液和衍生的血液代用品在溶液中都包含聚合的血红蛋白和巯基化合物，其中巯基化合物稳定聚合的血红蛋白。 本发明的方法包括在血红蛋白溶液中脱氧血红蛋白，然后将脱氧血红蛋白与巯基化合物混合以形成氧化稳定的脱氧血红蛋白溶液。 随后，将氧化稳定的脱氧血红蛋白溶液与交联剂混合以形成聚合反应混合物，然后将其聚合以形成稳定的聚合血红蛋白溶液。

    Battery separator
    3.
    发明授权
    Battery separator 失效
    电池分离器

    公开(公告)号：US5362581A

    公开(公告)日：1994-11-08

    申请号：US41085

    申请日：1993-04-01

    申请人： Victor S. Chang ,  Richard C. Hartwig ,  Joseph T. Lundquist ,  Marc E. Parham ,  Anthony J. Laccetti

    发明人： Victor S. Chang ,  Richard C. Hartwig ,  Joseph T. Lundquist ,  Marc E. Parham ,  Anthony J. Laccetti

    IPC分类号： H01M2/14 ,  H01M2/16

    CPC分类号： H01M2/14 ,  H01M2/1653

    摘要： A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a polycarbonate polymer and a filler or a polycarbonate and a structure enhancing agent, said sheet product having a porous sheet embedded within said mixture and between the first and second major surfaces. The porosity of the sheet product is at least about 50 volume percent composed of pores such that the nominal pore diameter increases incrementally from each major surface towards the interior central portion of the sheet product's thickness.

    摘要翻译： 一种由聚碳酸酯聚合物和填料或聚碳酸酯和结构增强剂的均匀混合物形成的具有第一和第二主表面的厚度小于约50密耳的微孔板产品的电池隔板，所述片材产品具有 嵌入所述混合物内并在第一和第二主表面之间的多孔片。 片材产品的孔隙率为由孔组成的至少约50体积％，使得标称孔径从片材产品厚度的每个主表面向内部中心部分逐渐增加。

    Microporous asymmetric polyamide membranes
    8.
    发明授权
    Microporous asymmetric polyamide membranes 失效
    微孔不对称聚酰胺膜

    公开(公告)号：US4770777A

    公开(公告)日：1988-09-13

    申请号：US8227

    申请日：1987-01-29

    申请人： Harvey Steadly ,  Anthony J. Laccetti

    发明人： Harvey Steadly ,  Anthony J. Laccetti

    IPC分类号： B01D67/00 ,  B01D69/10 ,  B01D69/12 ,  B01D71/56 ,  B29C41/16 ,  B29C41/28 ,  C08J9/28 ,  C08L77/00 ,  B01D13/00

    CPC分类号： B01D71/56 ,  B01D69/10 ,  B01D69/12

    摘要： Integral gradient, skinned, submicroscopically porous, anisotropic, hydrophilic, asymmetric polyamide membranes comprising:(a) a first porous polyamide zone obtained from a polyamide solution formulated to give coagulated film with pores of a given size,(b) a fabric support imbedded in the first porous polyamide layer, and(c) a second porous polyamide zone having a skinned outer surface, obtained from a polyamide solution having the same constituents as the solution used to form the first porous polyamide zone but solution post-treated to give pores substantially smaller than those in the first porous polyamide zone, as well as a process for producing such membranes, are disclosed.

    摘要翻译： 整体梯度，表皮，亚显微多孔，各向异性，亲水性，不对称聚酰胺膜，包括：（a）由配制成具有给定尺寸的孔的凝结膜的聚酰胺溶液获得的第一多孔聚酰胺区，（b）嵌入 第一多孔聚酰胺层，和（c）具有剥皮外表面的第二多孔聚酰胺区，由具有与用于形成第一多孔聚酰胺区的溶液相同的组分的聚酰胺溶液获得，然后后处理以产生基本上的孔 比第一多孔聚酰胺区中的那些小，以及这种膜的制造方法。

    Microporous polyurethane based battery separator
    10.
    发明授权
    Microporous polyurethane based battery separator 失效
    微孔聚氨酯基电池隔膜

    公开(公告)号：US5346788A

    公开(公告)日：1994-09-13

    申请号：US41740

    申请日：1993-04-01

    申请人： Victor S. C. Chang ,  Richard C. Hartwig ,  Joseph T. Lundquist ,  Marc E. Parham ,  Anthony J. Laccetti

    发明人： Victor S. C. Chang ,  Richard C. Hartwig ,  Joseph T. Lundquist ,  Marc E. Parham ,  Anthony J. Laccetti

    IPC分类号： H01M2/14 ,  H01M2/16

    CPC分类号： H01M2/1653 ,  H01M2/14

    摘要： A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a thermoplastic polyurethane polymer having a high degree of hard segments with a filler or said polyurethane with a structure enhancing agent, said sheet product having a sheet embedded within said mixture and between the first and second major surfaces. The sheet product has porosity of at least about 50 volume percent composed of pores such that the nominal pore diameter increases from each major surface towards the interior, center of the sheet product's thickness.

    摘要翻译： 一种由具有第一和第二主表面的厚度小于约50密耳的微孔板产品组成的电池隔板，由具有高度硬链段的热塑性聚氨酯聚合物与填料或所述聚氨酯的均匀混合物形成 所述片材产品具有嵌入所述混合物内的片材和所述第一和第二主表面之间。 片材产品具有由孔组成的至少约50体积％的孔隙率，使得标称孔径从每个主表面朝向内部，片材产品厚度的中心增加。