公开(公告)号：US20230324603A1

公开(公告)日：2023-10-12

申请号：US18321939

申请日：2023-05-23

申请人： Eric Swanson ,  Anthony Kam

发明人： Eric Swanson ,  Anthony Kam

IPC分类号： G02B6/02 ,  A61B1/07 ,  A61B5/00 ,  A61B1/00 ,  A61B3/10 ,  A61B5/02

CPC分类号： G02B6/02042 ,  A61B1/07 ,  A61B5/0066 ,  A61B1/0016 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/00177 ,  A61B3/10 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  G01B9/02091

摘要： An optical probe imaging system includes an optical probe with a multicore optical fiber positioned therein. Distal optics are optically coupled to the distal end of the multicore fiber that image light propagating in the multicore fiber so as to generate a light pattern on a sample that is based on a relative position of at least two cores at a distal facet of the multicore fiber. A distal motor is mechanically coupled to the optical probe so that a motion of the distal motor causes the light pattern to traverse a path across the sample. An optical receiver is coupled to the proximal end of the multicore fiber and receives light that has traversed the path across the sample and then generates an electrical signal corresponding to the received light. A processor maps the electrical signal to a representation of information about the sample, wherein the mapping is based on the relative position of at least two cores at the distal facet of the multicore fiber and on the motion of the distal motor.

公开(公告)号：US11681093B2

公开(公告)日：2023-06-20

申请号：US16865454

申请日：2020-05-04

申请人： Eric Swanson ,  Anthony Kam

发明人： Eric Swanson ,  Anthony Kam

IPC分类号： A61B1/00 ,  A61B1/07 ,  A61B3/10 ,  A61B5/00 ,  A61B5/02 ,  G02B6/02 ,  G01B9/02091

CPC分类号： G02B6/02042 ,  A61B1/0016 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/00177 ,  A61B1/07 ,  A61B3/10 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  G01B9/02091

摘要： An optical probe imaging system includes an optical probe having a multicore optical fiber. Distal optics image light propagating in the multicore optical fiber so as to generate a light pattern on a sample that is based on a relative position of the cores. A distal motor causes the light pattern to traverse a path across the sample. An optical receiver includes a first receiver receiving light that has traversed the path across the sample from one of the at least two cores and a second receiver receiving light that has traversed the path across the sample from the other of the cores, such that the first receiver and the second receiver detect light in parallel. A processor maps relative position of the cores at the distal facet based on signals generated by the receiver.

公开(公告)号：US07045585B2

公开(公告)日：2006-05-16

申请号：US10101568

申请日：2002-03-20

申请人： Leslie Roy Berry ,  Hugh O'Brodovich, legal representative ,  Anthony Kam Chuen Chan

发明人： Maureen Andrew, deceased

IPC分类号： A61L27/00 ,  C07K14/435 ,  C07K14/00 ,  A61F11/00

CPC分类号： A61L33/0041 ,  A61K47/61 ,  A61L27/20 ,  A61L33/0029 ,  Y10S623/92 ,  C08L5/10

摘要： Novel conjugates of glycosaminoglycans, particularly heparin and dermatan sulfate, and amine containing species and therapeutic uses thereof are described. In particular, mild methods of conjugating heparins to proteins, such as antithrombin III and heparin cofactor II, which provide covalent conjugates which retain maximal biological activity are described. Uses of these conjugates to prevent thrombogenesis, in particular in lung airways, such as found in infant and adult respiratory distress syndrome, and on surfaces in contact with blood are also described.

摘要翻译： 描述了糖胺聚糖，特别是肝素和硫酸皮肤素的新型缀合物和含胺物质及其治疗用途。 特别地，描述了提供维持最大生物学活性的提供共价缀合物的肝素与蛋白质（例如抗凝血酶III和肝素辅因子II）的温和方法。 还描述了这些缀合物用于预防血栓形成，特别是在肺气道中的用途，例如在婴儿和成人呼吸窘迫综合征中发现的以及与血液接触的表面。

公开(公告)号：US20050041601A1

公开(公告)日：2005-02-24

申请号：US10887249

申请日：2004-07-08

申请人： Anthony Kam ,  Raymond Xie ,  Tao Yang ,  Naimish Patel

发明人： Anthony Kam ,  Raymond Xie ,  Tao Yang ,  Naimish Patel

IPC分类号： G06F20060101 ,  H04J1/16 ,  H04L12/26 ,  H04L12/28

CPC分类号： H04J3/14 ,  H04J3/1611

摘要： A shared protect link extends between adjacent nodes that are shared by two or more adjacent BLSR rings. The shared protect link obviates the need for separate protect links between the adjacent nodes for each of the rings. A composite BLSR controller resides in each of the adjacent nodes. The composite BLSR controllers coordinate usage of the shared protect link, for example as a result of a span switch or a ring switch request. The composite BLSR controllers also coordinate transmission of signaling information for each of the rings over the common span between the adjacent nodes. In one embodiment, the signaling information is sent over separate channels of the common span. In another embodiment, the signaling information is multiplexed over the shared protect link. Each ring can be assigned a ring ID. The communication protocol between the adjacent nodes can be modified to tag the signaling information with the appropriate ring ID. The composite BLSR controller can include a standard BLSR controller for each of the adjacent rings and a translator logically between the standard BLSR controllers and the spans.

摘要翻译： 共享保护链路在由两个或更多个相邻BLSR环共享的相邻节点之间延伸。 共享保护链路消除了对于每个环的相邻节点之间的单独保护链路的需要。 复合BLSR控制器驻留在每个相邻节点中。 复合BLSR控制器协调共享保护链路的使用，例如作为跨度交换机或环网交换机请求的结果。 复合BLSR控制器还协调在相邻节点之间的公共跨度上的每个环的信令信息的传输。 在一个实施例中，信令信息在公共跨度的不同信道上发送。 在另一个实施例中，信令信息在共享保护链路上被复用。 每个戒指都可以分配一个戒指ID。 可以修改相邻节点之间的通信协议，以使用适当的环ID标记信令信息。 复合BLSR控制器可以包括用于每个相邻环的标准BLSR控制器和逻辑上在标准BLSR控制器和跨度之间的转换器。

公开(公告)号：US20240181024A1

公开(公告)日：2024-06-06

申请号：US18552534

申请日：2022-03-25

申请人： Leslie Roy BERRY ,  Anthony Kam Chuen CHAN ,  William JACKSON ,  Attilio DIFIORE

发明人： Leslie Roy BERRY ,  Anthony Kam Chuen CHAN ,  William JACKSON ,  Attilio DIFIORE

IPC分类号： A61K38/55 ,  A61K9/00 ,  A61K47/61

CPC分类号： A61K38/55 ,  A61K9/0019 ,  A61K9/0078 ,  A61K47/61

摘要： A method of treating or preventing a respiratory infection can include delivering aerosolized droplets of an antiviral solution to lung tissue of a subject, the antiviral solution including an aqueous carrier and an ATH conjugate that is solubilized in the aqueous carrier. The ATH conjugate includes antithrombin covalently bonded to heparin, the heparin including a polysaccharide chain having from about 15 to about 1,500 monosaccharide units.

公开(公告)号：US20210341668A1

公开(公告)日：2021-11-04

申请号：US16865454

申请日：2020-05-04

申请人： Eric Swanson ,  Anthony Kam

发明人： Eric Swanson ,  Anthony Kam

IPC分类号： G02B6/02 ,  A61B1/07 ,  A61B1/00 ,  G01B9/02 ,  A61B5/00

摘要： An optical probe imaging system includes an optical probe with a multicore optical fiber positioned therein. Distal optics are optically coupled to the distal end of the multicore fiber that image light propagating in the multicore fiber so as to generate a light pattern on a sample that is based on a relative position of at least two cores at a distal facet of the multicore fiber. A distal motor is mechanically coupled to the optical probe so that a motion of the distal motor causes the light pattern to traverse a path across the sample. An optical receiver is coupled to the proximal end of the multicore fiber and receives light that has traversed the path across the sample and then generates an electrical signal corresponding to the received light. A processor maps the electrical signal to a representation of information about the sample, wherein the mapping is based on the relative position of at least two cores at the distal facet of the multicore fiber and on the motion of the distal motor.

公开(公告)号：US20050041575A1

公开(公告)日：2005-02-24

申请号：US10886154

申请日：2004-07-07

申请人： Anthony Kam ,  Raymond Xie ,  Tao Yang ,  Naimish Patel

发明人： Anthony Kam ,  Raymond Xie ,  Tao Yang ,  Naimish Patel

IPC分类号： G06F20060101 ,  H04J1/16 ,  H04L12/26 ,  H04L12/28

CPC分类号： H04J3/14 ,  H04J3/1611

摘要： Each span of a communication network, such as a BLSR ring, is assigned a unique span ID. When a node of the network detects a failure in a span (including a straddling span) of the network, the node exchanges commands, according to an automatic protection switching (APS) protocol, that request other nodes of the network to switch network traffic from a working span (including a straddling span) to a protect span. The commands specify the working span by its span ID, without necessarily specifying a source node ID or a destination node ID for the commands. The span ID occupies fewer bits in the commands than a combination of the source node ID and the destination node ID. Consequently, the messages can accommodate span IDs larger than four bits, and networks can have more than 16 nodes. Alternatively, the commands specify a destination node ID without a span ID or a source node ID, or the commands specify a source node ID without a span ID or a destination node ID. Alternatively, a straddling span is identified by node IDs of its two nonadjacent terminal nodes. A set of rules governs straddling span switching. Optionally or in addition, more than four bits are available for bridge requests command codes in the messages. Thus, more than 16 unique bridge requests commands can be defined.

摘要翻译： 诸如BLSR环的通信网络的每个跨度被分配唯一的跨度ID。 当网络的节点检测到网络的跨度（包括跨度跨度）的故障时，节点根据自动保护倒换（APS）协议交换命令，请求网络的其他节点将网络流量从 工作范围（包括跨跨跨度）到保护范围。 这些命令通过其跨度ID指定工作范围，而不必为命令指定源节点ID或目标节点ID。 与源节点ID和目标节点ID的组合相比，该范围ID在命令中占用较少的位。 因此，消息可以容纳大于四位的跨度ID，并且网络可以具有多于16个节点。 或者，命令指定没有跨度ID或源节点ID的目标节点ID，或者该命令指定没有跨度ID或目的地节点ID的源节点ID。 或者，跨越跨度由其两个不相邻终端节点的节点ID标识。 一套规则管理跨越跨度切换。 可选地或另外，消息中的桥请求命令码可以有四位以上。 因此，可以定义超过16个独特的桥请求命令。