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公开(公告)号：US20110117015A1
公开(公告)日：2011-05-19
申请号：US13000794
申请日：2009-07-21
申请人： Armando Rossello , Elisa Nuti , Stanislava Ivanova Avramova , Fulvio Uggeri , Alessandro Maiocchi
发明人： Armando Rossello , Elisa Nuti , Stanislava Ivanova Avramova , Fulvio Uggeri , Alessandro Maiocchi
IPC分类号： A61K51/04 , C07C311/01 , C07D209/48 , C07D403/02 , C07D241/02 , C07D403/14 , A61K31/18 , A61K31/4035 , A61K31/497 , A61K49/00 , A61P9/10 , A61P25/28 , A61P9/00 , A61P37/02
CPC分类号： A61K49/0017 , A61K49/085 , A61K49/10 , A61K49/101 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/221 , A61K51/0497
摘要： The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, G and n have the meanings reported in the specification, properly labelled with diagnostic imaging moieties or even radiotherapeutic moieties. The invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as diagnostic imaging agents or radiotherapeutic agents.
摘要翻译： 本发明涉及具有对金属蛋白酶MMP的亲和力的芳基 - 磺酰氨基化合物，其具有式（I），其中R，R 1，R 2，R 3，G和n具有说明书中报道的含义，适当地用诊断成像部分或甚至 放射治疗部分。 本发明还涉及其制备方法，包含它们的药物组合物及其作为诊断显像剂或放射治疗剂的用途。
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公开(公告)号：US09480758B2
公开(公告)日：2016-11-01
申请号：US13000794
申请日：2009-07-21
申请人： Armando Rossello , Elisa Nuti , Stanislava Ivanova Avramova , Fulvio Uggeri , Alessandro Maiocchi
发明人： Armando Rossello , Elisa Nuti , Stanislava Ivanova Avramova , Fulvio Uggeri , Alessandro Maiocchi
CPC分类号： A61K49/0017 , A61K49/085 , A61K49/10 , A61K49/101 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/221 , A61K51/0497
摘要： The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, G and n have the meanings reported in the specification, properly labelled with diagnostic imaging moieties or even radiotherapeutic moieties. The invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as diagnostic imaging agents or radiotherapeutic agents.
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3.发明授权Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors 失效具有芳基 - 磺酰胺结构的化合物可用作金属蛋白酶抑制剂公开(公告)号：US08329751B2
公开(公告)日：2012-12-11
申请号：US12531119
申请日：2008-03-14
IPC分类号： A61K31/495 , A61K31/4035 , A61K31/18 , C07D295/088 , C07D209/48 , C07D311/48
CPC分类号： C07C311/48 , C07D295/08 , C07D295/088
摘要： The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, R4, R5, n and m have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.
摘要翻译： 本发明涉及赋予对金属蛋白酶MMP的抑制活性的芳基磺酰胺化合物，其具有式（I），其中R，R 1，R 2，R 3，R 4，R 5，n和m具有本说明书中报道的含义; 本发明还涉及其制备方法，包含它们的药物组合物及其作为治疗剂的用途，特别是治疗退行性疾病。
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4.发明申请公开(公告)号：US20110124653A1
公开(公告)日：2011-05-26
申请号：US13054590
申请日：2009-07-21
IPC分类号： A61K31/497 , C07C237/48 , C07D241/04 , A61K31/166 , A61P25/28 , A61P9/10 , A61P19/02 , A61P11/00 , A61P35/00
CPC分类号： C07D295/205
摘要： The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M′) (I), wherein M and M′, the same or different from each other, represent the residues of the metalloproteases inhibitors of formula (II), wherein R, R1, R2, R3, G and n have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.
摘要翻译： 本发明涉及具有下式（I）（M）-L-（M'）（I）的金属蛋白酶MMP抑制活性的二聚芳基 - 磺酰氨基化合物，其中M和M'彼此相同或不同 表示式（II）的金属蛋白酶抑制剂的残基，其中R，R1，R2，R3，G和n具有说明书中报道的含义; 本发明还涉及其制备方法，包含它们的药物组合物及其作为治疗剂的用途，特别是治疗退行性疾病。
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5.发明申请Compounds Having Aryl-Sulphonamidic Structure Useful As Metalloproteases Inhibitors 失效具有芳基磺酰胺结构的化合物可用作金属蛋白酶抑制剂公开(公告)号：US20100087505A1
公开(公告)日：2010-04-08
申请号：US12531119
申请日：2008-03-14
IPC分类号： A61K31/404 , C07C313/06 , C07D209/36 , A61K31/18 , A61P35/00
CPC分类号： C07C311/48 , C07D295/08 , C07D295/088
摘要： The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, R4, R5, n and m have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.
摘要翻译： 本发明涉及赋予对金属蛋白酶MMP的抑制活性的芳基磺酰胺化合物，其具有式（I），其中R，R 1，R 2，R 3，R 4，R 5，n和m具有本说明书中报道的含义; 本发明还涉及其制备方法，包含它们的药物组合物及其作为治疗剂的用途，特别是治疗退行性疾病。
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公开(公告)号：US08093386B2
公开(公告)日：2012-01-10
申请号：US12309701
申请日：2007-07-25
IPC分类号： C07D207/40 , C07D209/48 , C07D211/40 , C07D211/54 , C07D239/02 , C07C57/13 , C07C259/04 , C07C311/10 , A61K31/18 , A61K31/19 , A61K31/40 , A61K31/445 , A61K31/515
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C323/62 , C07D207/46 , C07D209/48 , C07D211/76 , C07D239/60 , C07F9/3882
摘要： There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc metalloproteinases.
摘要翻译： 描述了具有下面通式（I）的化合物及其药学上可接受的盐，其中E，X，m，q，R 1，R 2，n和ZBG具有在本说明书中报道的含义，在治疗中作为抑制剂 锌金属蛋白酶。
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公开(公告)号：US20090239829A1
公开(公告)日：2009-09-24
申请号：US12309701
申请日：2007-07-25
IPC分类号： A61K31/662 , C07C233/64 , A61K31/165 , C07D333/06 , A61K31/381 , C07F9/38 , C07D207/00 , A61K31/40 , C07D239/02 , A61K31/515 , C07D211/40 , A61K31/445 , A61P35/00
CPC分类号： C07C317/44 , C07C317/14 , C07C317/22 , C07C323/62 , C07D207/46 , C07D209/48 , C07D211/76 , C07D239/60 , C07F9/3882
摘要： There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc metalloproteinases.
摘要翻译： 描述了具有下面通式（I）的化合物及其药学上可接受的盐，其中E，X，m，q，R 1，R 2，n和ZBG具有在本说明书中报道的含义，在治疗中作为抑制剂 锌金属蛋白酶。
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