公开(公告)号：US09309188B2

公开(公告)日：2016-04-12

申请号：US13577278

申请日：2011-02-01

申请人： Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

发明人： Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

IPC分类号： C07B37/04 ,  C07B49/00 ,  C07C1/32 ,  C07C15/44 ,  C07C43/205 ,  C07C253/04 ,  C07C17/263 ,  C07C41/30 ,  C07C67/343 ,  C07C209/68 ,  C07C253/30 ,  C07C1/30 ,  C07C17/26 ,  C07C41/24 ,  C07C209/74

CPC分类号： C07C253/04 ,  C07B37/04 ,  C07B49/00 ,  C07C1/30 ,  C07C1/326 ,  C07C17/26 ,  C07C17/2632 ,  C07C41/24 ,  C07C41/30 ,  C07C67/343 ,  C07C209/68 ,  C07C209/74 ,  C07C253/30 ,  C07C2527/128 ,  C07C2531/22 ,  C07C2603/26 ,  C07C11/02 ,  C07C15/44 ,  C07C43/2055 ,  C07C43/205 ,  C07C69/612 ,  C07C25/24 ,  C07C211/48 ,  C07C255/50

摘要： What is described is a process for preparing organic compounds of the general formula (I) R—R′  (I) by converting a corresponding compound of the general formula (II) R—X  (II) in which X is fluorine, chlorine, bromine or iodine to an organomagnesium compound of the general formula (III) [M+]n[RmMgXkY1]  (III) wherein compounds of the formula (III) are reacted with a compound of the general formula (IV) characterized in that the reaction of (III) with (IV) is performed in the presence of a) catalytic amounts of an iron compound, based on the compound of the general formula (II), and optionally in the presence of b) a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II).

摘要翻译： 描述的是通过将相应的通式（II）化合物R-X（II）转化为其中X为氟，氯，氯， 溴或碘与通式（III）的有机镁化合物[M +] n [RmMgXkY1]（III）反应，其中式（III）化合物与通式（IV）的化合物反应，其特征在于： （III）与（IV）的化合物在a）催化量的铁化合物存在下进行，基于通式（II）的化合物，并且任选在b）氮，氧和/ 或基于通式（II）的化合物的催化或化学计量的含磷添加剂。

公开(公告)号：US08030520B2

公开(公告)日：2011-10-04

申请号：US12407947

申请日：2009-03-20

申请人： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldemar Maximilian Czaplik

发明人： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldemar Maximilian Czaplik

IPC分类号： C07C211/00

CPC分类号： C07C1/326 ,  C07B37/04 ,  C07C2523/745 ,  C07C2523/75

摘要： This invention relates to a process for preparing functionalized aryl, heteroaryl, cycloalkenyl, or alkenyl compounds, by a transition-metal-catalyzed cross-coupling reaction of a substituted or unsubstituted aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide, where X is a halide, diazonium, tosylate (p-toluenesulphonate), mesylate (methanesulphonate) or triflate (trifluoromethanesulphonate) leaving group.

摘要翻译： 本发明涉及通过取代或未取代的芳基-X，杂芳基-X，环烯基-X或链烯基-X的过渡金属催化交叉偶联反应制备官能化芳基，杂芳基，环烯基或烯基化合物的方法 与烷基，烯基，环烷基或环烯基卤化物的化合物，其中X是卤化物，重氮，甲苯磺酸酯（对甲苯磺酸酯），甲磺酸酯（甲磺酸酯）或三氟甲磺酸酯（三氟甲磺酸酯）离去基团。

公开(公告)号：US20090247764A1

公开(公告)日：2009-10-01

申请号：US12407947

申请日：2009-03-20

申请人： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldermar Maximilian Czaplik

发明人： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldermar Maximilian Czaplik

IPC分类号： C07D213/127 ,  C07C2/58

CPC分类号： C07C1/326 ,  C07B37/04 ,  C07C2523/745 ,  C07C2523/75

摘要： A process for preparing organic compounds of the general formula (I) R—R′  (I), where R is a substituted or unsubstituted aromatic, heteroaromatic, cycloalkenylic or alkenylic radical and R′ is a substituted or unsubstituted alkylic, alkenylic, cycloalkylic or cycloalkenylic radical, by reacting a corresponding compound of the general formula (II) R—X  (II), where X is chlorine, bromine, iodine, diazonium, mesylate (methanesulphonate), tosylate (p-toluenesulphonate) or triflate (trifluorosutphonate) and R is as defined for formula (I), with a corresponding compound of the general formula (III) R′—Y  (III), where Y is chlorine, bromine or iodine and R′ is as defined for formula (I), wherein the reaction is carried out in the presence of a) stoichiometric amounts of elemental magnesium, based on the compound of the general formula (II), and b) catalytic amounts of a transition metal compound, based on the compound of the general formula (II), and, if appropriate, c) in the presence of a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II), is described. It is particularly advantageous that the process of the invention is carried out as a one-pot reaction and the organomagnesium compound (Grignard compound) formed in situ as intermediate is not isolated.

公开(公告)号：US20130184485A1

公开(公告)日：2013-07-18

申请号：US13577278

申请日：2011-02-01

申请人： Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

发明人： Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

IPC分类号： C07C253/04 ,  C07C1/30 ,  C07C17/26 ,  C07C209/74 ,  C07C41/24

CPC分类号： C07C253/04 ,  C07B37/04 ,  C07B49/00 ,  C07C1/30 ,  C07C1/326 ,  C07C17/26 ,  C07C17/2632 ,  C07C41/24 ,  C07C41/30 ,  C07C67/343 ,  C07C209/68 ,  C07C209/74 ,  C07C253/30 ,  C07C2527/128 ,  C07C2531/22 ,  C07C2603/26 ,  C07C11/02 ,  C07C15/44 ,  C07C43/2055 ,  C07C43/205 ,  C07C69/612 ,  C07C25/24 ,  C07C211/48 ,  C07C255/50

摘要： What is described is a process for preparing organic compounds of the general formula (I) R—R′  (I) by converting a corresponding compound of the general formula (II) R—X   (II) in which X is fluorine, chlorine, bromine or iodine to an organomagnesium compound of the general formula (III) [M+]n[RmMgXkY1]  (III) wherein compounds of the formula (III) are reacted with a compound of the general formula (IV) characterized in that the reaction of (III) with (IV) is performed in the presence of a) catalytic amounts of an iron compound, based on the compound of the general formula (II), and optionally in the presence of b) a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II).

摘要翻译： 描述的是通过将相应的通式（II）RX（II）的化合物（其中X是氟，氯，溴或溴）或其盐，其中R 1，R 2， 碘与通式（III）的化合物（III）反应的通式（III）的有机镁化合物[M +] n [RmMgXkY1]（III）其中式（III）化合物与通式（IV）的化合物反应，其特征在于（III ）与（IV）化合物在（a）催化量的铁化合物（基于通式（II）的化合物）存在下进行，任选在b）氮，氧和/或磷 基于通式（II）的化合物，催化剂或化学计量的添加剂。

公开(公告)号：US20120046471A1

公开(公告)日：2012-02-23

申请号：US13232028

申请日：2011-09-14

申请人： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldermar Maximilian Czaplik

发明人： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldermar Maximilian Czaplik

IPC分类号： C07D213/16 ,  C07C1/26 ,  C07C209/68 ,  C07C67/343 ,  C07C41/30

CPC分类号： C07C1/326 ,  C07B37/04 ,  C07C2523/745 ,  C07C2523/75

摘要： This invention relates to a process for preparing functionalized aryl, heteroaryl, cycloalkenyl, or alkenyl compounds, by a transition-metal-catalyzed cross-coupling reaction of a substituted or unsubstituted aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide, where X is a halide, diazonium, tosylate (p-toluenesulphonate), mesylate (methanesulphonate) or triflate (trifluoromethanesulphonate) leaving group.

摘要翻译： 本发明涉及通过取代或未取代的芳基-X，杂芳基-X，环烯基-X或链烯基-X的过渡金属催化交叉偶联反应制备官能化芳基，杂芳基，环烯基或烯基化合物的方法 与烷基，烯基，环烷基或环烯基卤化物的化合物，其中X是卤化物，重氮，甲苯磺酸酯（对甲苯磺酸酯），甲磺酸酯（甲磺酸酯）或三氟甲磺酸酯（三氟甲磺酸酯）离去基团。