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公开(公告)号：US20150307627A1
公开(公告)日：2015-10-29
申请号：US14702574
申请日：2015-05-01
申请人： BAC IP B.V.
CPC分类号： C07K16/4283 , A61K47/6843 , C07K16/18 , C07K2317/22 , C07K2317/33 , C07K2317/569 , C07K2317/92 , C07K2317/94
摘要： The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.
摘要翻译： 本申请涉及能够结合哺乳动物IgG的抗原结合蛋白。 本申请的抗原结合蛋白的框架区域优选对应于天然缺乏轻链的抗体的框架工作区。 在骆驼中找到。 本申请还涉及编码这种抗原结合蛋白的核酸，包含这些蛋白质的免疫吸附材料，用于这些免疫吸附材料用于纯化哺乳动物IgG抗体和用于治疗性单采血液成像术。
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公开(公告)号：US10259886B2
公开(公告)日：2019-04-16
申请号：US14702574
申请日：2015-05-01
申请人： BAC IP B.V.
摘要： The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.
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3.发明申请公开(公告)号：US20180305461A1
公开(公告)日：2018-10-25
申请号：US15799920
申请日：2017-10-31
申请人： Bac IP B.V.
发明人： Wilhelmus Josephus Johanna HERMANS , Sven BLOKLAND , Maria Anna VAN KESTEREN , Johanna Magaretha HORREVOETS , Franciscus Johan Marinus DETMERS
CPC分类号： C07K16/4241 , C07K1/22 , C07K16/065 , C07K16/42 , C07K16/4283 , C07K2317/22 , C07K2317/33 , C07K2317/34 , C07K2317/522 , C07K2317/569
摘要： The present invention relates to a method for the purification of a human IgG-CH1 domain comprising molecule using an antigen-binding protein that is capable of binding to an epitope that is comprised in the CH1 domain of each of human IgG1, human IgG2, human IgG3 and human IgG4. The invention further relates to the antigen-binding proteins that can be used in the method of the invention. The framework regions of the antigen-binding proteins of the invention preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The invention further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, and to the uses of such immunoadsorbent materials for the purification of IgG-CH1 domain containing molecules from a variety of species.
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公开(公告)号：US20170369527A1
公开(公告)日：2017-12-28
申请号：US15616781
申请日：2017-06-07
申请人： BAC IP B.V.
CPC分类号： C07K1/22 , A61K39/44 , C07K16/42 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/565 , C07K2317/569 , C07K2317/92
摘要： The invention relates to a method of immunoaffinity purification which comprises the use of a binding agent which binds to an epitope that it is present at least twice on the target molecule. In another embodiment the method uses at least two different binding agents, each binding to different epitopes on the target molecule.
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公开(公告)号：US20140256579A1
公开(公告)日：2014-09-11
申请号：US14174750
申请日：2014-02-06
申请人： BAC IP B.V.
IPC分类号： G01N33/543 , C07K16/00
CPC分类号： G01N33/54393 , B01D15/3804 , C07K1/047 , C07K16/00 , C07K16/14 , C07K16/18 , C07K16/42 , C07K16/44 , C07K2317/22 , C07K2317/56 , C40B30/04 , G01N33/6842 , G01N33/6845
摘要： Protein arrays are provided comprising single domain antibodies obtainable from Camelidae which are capable of detecting even minor changes in the expression of proteins in cell and tissue extracts and having an optimal signal to noise ratio by removing non-informative abundant proteins from said cell or tissue extracts.
摘要翻译： 提供的蛋白质阵列包括可从Camelidae获得的单结构域抗体，其能够通过从所述细胞或组织提取物中去除非信息丰富的蛋白质来检测细胞和组织提取物中蛋白质的表达甚至微小变化并具有最佳的信噪比 。
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公开(公告)号：US20210347816A1
公开(公告)日：2021-11-11
申请号：US17239195
申请日：2021-04-23
申请人： BAC IP B.V.
摘要： The invention relates to a method of immunoaffinity purification which comprises the use of a binding agent which binds to an epitope that is present at least twice on the target molecule. In another embodiment the method uses at least two different binding agents, each binding to different epitopes on the target molecule.
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公开(公告)号：US20160207986A1
公开(公告)日：2016-07-21
申请号：US14997924
申请日：2016-01-18
申请人： BAC IP B.V.
IPC分类号： C07K16/16 , A61K47/48 , C07K16/18 , G01N33/577 , G01N33/68
CPC分类号： C07K16/16 , A61K47/61 , C07K16/18 , C07K16/4283 , C07K17/00 , C07K2317/22 , C07K2317/40 , C07K2317/569 , C07K2317/62 , G01N33/577 , G01N33/6857
摘要： The immobilisation of single domain antigen binding fragments of antibodies naturally devoid of light chains, or protein domains functionally equivalent thereto, onto a solid surface through covalent cross-linking is described. The binding fragments are devoid of any appended polypeptide tail or linking group. Materials comprising fragments so immobilised and uses thereof are also described.
摘要翻译： 描述了通过共价交联将固有的通过共价交联固定在固体表面上的抗体的单结构域抗原结合片段固定在固体表面上，其自然不含有轻链或其功能上等同的蛋白质结构域。 结合片段没有任何附加的多肽尾或连接基团。 还描述了包含如此固定的片段的材料及其用途。
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公开(公告)号：US20160024148A1
公开(公告)日：2016-01-28
申请号：US14820446
申请日：2015-08-06
申请人： BAC IP B.V.
CPC分类号： C07K1/22 , A61K39/44 , C07K16/42 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/565 , C07K2317/569 , C07K2317/92
摘要： The invention relates to a method of immunoaffinity purification which comprises the use of a binding agent which binds to an epitope that it is present at least twice on the target molecule. In another embodiment the method uses at least two different binding agents, each binding to different epitopes on the target molecule.
摘要翻译： 本发明涉及一种免疫亲和纯化方法，其包括使用结合试剂，其结合表位，其在靶分子上存在至少两次。 在另一个实施方案中，该方法使用至少两种不同的结合剂，每种结合剂结合靶分子上的不同表位。
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公开(公告)号：US20190177434A1
公开(公告)日：2019-06-13
申请号：US16282082
申请日：2019-02-21
申请人： BAC IP B.V
摘要： The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.
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