-
公开(公告)号：US08231866B2
公开(公告)日：2012-07-31
申请号：US13353524
申请日：2012-01-19
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
-
公开(公告)号：US20110081346A1
公开(公告)日：2011-04-07
申请号：US12943256
申请日：2010-11-10
申请人： CAMERON S. BRANDT , JACOB J. KENNEDY , WENFENG XU , EUGENE C. YI , BRIAN A. FOX , ZEREN GAO , PALLAVUR V. SIVAKUMAR
发明人： CAMERON S. BRANDT , JACOB J. KENNEDY , WENFENG XU , EUGENE C. YI , BRIAN A. FOX , ZEREN GAO , PALLAVUR V. SIVAKUMAR
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C07H21/00 , A61P35/00 , C12N15/63 , C12N5/10 , C12P21/02 , C12N5/0783 , C12N5/09
CPC分类号： C07K16/2827 , A61K47/6851 , A61K2039/505 , C07K14/70532 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2319/30 , G01N33/5011 , G01N2333/705 , G01N2500/02
摘要： Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.
摘要翻译： 公开了一种新鉴定的B7家族成员，zB7H6，其作为NK细胞触发受体NKp30的反受体。 还公开了基于zB7H6与NKp30的相互作用调节NKp30介导的NK细胞活性的方法和组合物以及相关筛选方法。 还公开了抗zB7H6抗体以及包含与治疗剂缀合的抗-zB7H6抗体的抗体 - 药物偶联物，包括使用这种抗体和抗体 - 药物偶联物对表达zB7H6的细胞施加治疗效果的方法。
-
公开(公告)号：US20110027263A1
公开(公告)日：2011-02-03
申请号：US12899700
申请日：2010-10-07
申请人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
发明人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
-
公开(公告)号：US07858759B2
公开(公告)日：2010-12-28
申请号：US12246214
申请日：2008-10-06
申请人： Cameron S. Brandt , Jacob J. Kennedy , Wenfeng Xu , Eugene C. Yi , Brian A. Fox , Zeren Gao
发明人： Cameron S. Brandt , Jacob J. Kennedy , Wenfeng Xu , Eugene C. Yi , Brian A. Fox , Zeren Gao
IPC分类号： C07K16/00
CPC分类号： C07K16/2827 , A61K47/6851 , A61K2039/505 , C07K14/70532 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2319/30 , G01N33/5011 , G01N2333/705 , G01N2500/02
摘要： Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.
摘要翻译： 公开了一种新鉴定的B7家族成员，zB7H6，其作为NK细胞触发受体NKp30的反受体。 还公开了基于zB7H6与NKp30的相互作用调节NKp30介导的NK细胞活性的方法和组合物以及相关筛选方法。 还公开了抗zB7H6抗体以及包含与治疗剂缀合的抗-zB7H6抗体的抗体 - 药物偶联物，包括使用这种抗体和抗体 - 药物偶联物对表达zB7H6的细胞施加治疗效果的方法。
-
5.发明授权Method of using interferon-like potein ZCYTO20 (IL-28A) or ZCYTO22(IL-28B) to treat hepatitis B 有权使用干扰素样potein ZCYTO20（IL-28A）或ZCYTO22（IL-28B）治疗乙型肝炎的方法公开(公告)号：US07829076B2
公开(公告)日：2010-11-09
申请号：US12630571
申请日：2009-12-03
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
-
6.发明申请A METHOD OF USING INTERFERON-LIKE POTEIN ZCYTO20 (IL-28A) OR ZCYTO22(IL-28B) TO TREAT HEPATITIS B 有权使用干扰素ZCYTO20（IL-28A）或ZCYTO22（IL-28B）治疗HEPATITIS B的方法公开(公告)号：US20100227813A1
公开(公告)日：2010-09-09
申请号：US12630571
申请日：2009-12-03
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
-
公开(公告)号：US07655439B2
公开(公告)日：2010-02-02
申请号：US11530672
申请日：2006-09-11
申请人： Margaret Dow Moore , Brian A. Fox
发明人： Margaret Dow Moore , Brian A. Fox
IPC分类号： C12P21/06
CPC分类号： C12N15/62 , A61K38/00 , C07K14/005 , C07K14/705 , C07K2319/03 , C07K2319/81 , C12N2740/10022 , C12N2740/13022
摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.
摘要翻译： 本发明涉及一种三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。 在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。 在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。 该方法可用于产生同型和异三聚体蛋白质。 本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。
-
公开(公告)号：US07585948B2
公开(公告)日：2009-09-08
申请号：US11458367
申请日：2006-07-18
申请人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
发明人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
IPC分类号： C07K14/705 , C12P21/02
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
-
公开(公告)号：US20090220502A1
公开(公告)日：2009-09-03
申请号：US12246214
申请日：2008-10-06
申请人： Cameron S. Brandt , Jacob J. Kennedy , Wenfeng Xu , Eugene C. Yi , Brian A. Fox , Zeren Gao , Pallavur V. Sivakumar
发明人： Cameron S. Brandt , Jacob J. Kennedy , Wenfeng Xu , Eugene C. Yi , Brian A. Fox , Zeren Gao , Pallavur V. Sivakumar
IPC分类号： A61K39/395 , C07K14/00 , C07H21/00 , C12N15/74 , C12N1/00 , C07K16/18 , A61K38/16 , G01N33/53 , A61P35/00
CPC分类号： C07K16/2827 , A61K47/6851 , A61K2039/505 , C07K14/70532 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2319/30 , G01N33/5011 , G01N2333/705 , G01N2500/02
摘要： Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.
摘要翻译： 公开了一种新鉴定的B7家族成员，zB7H6，其作为NK细胞触发受体NKp30的反受体。 还公开了基于zB7H6与NKp30的相互作用调节NKp30介导的NK细胞活性的方法和组合物以及相关筛选方法。 还公开了抗zB7H6抗体以及包含与治疗剂缀合的抗-zB7H6抗体的抗体 - 药物偶联物，包括使用这种抗体和抗体 - 药物偶联物对表达zB7H6的细胞施加治疗效果的方法。
-
公开(公告)号：US20080214788A1
公开(公告)日：2008-09-04
申请号：US11971624
申请日：2008-01-09
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
-
-
-
-
-
-
-
-
-
搜索结果
71 条记录 (耗时 0.053 秒)