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    Immunoassays with novel labeled carbamazepine hapten analogues
    1.
    发明授权
    Immunoassays with novel labeled carbamazepine hapten analogues 失效
    新型标记卡马西平半抗原类似物的免疫测定

    公开(公告)号：US5578457A

    公开(公告)日：1996-11-26

    申请号：US926202

    申请日：1992-08-07

    申请人： Barbara A. Brummond ,  Mohan S. Saini ,  Ignazio S. Ponticello

    发明人： Barbara A. Brummond ,  Mohan S. Saini ,  Ignazio S. Ponticello

    IPC分类号： C07D223/22 ,  C07D403/12 ,  G01N33/535 ,  G01N33/94 ,  G01N33/545 ,  C12N9/96

    CPC分类号： C07D403/12 ,  C07D223/22 ,  G01N33/535 ,  G01N33/9486 ,  Y10S436/815

    摘要： An immunoassay method and analytical elements for detecting carbamazepine drugs, for example, in body fluids, is described. The immunoassay method comprises:(A) contacting a liquid sample, containing carbamazepine, with a labeled carbamazepine analogue in the presence of antibodies for carbamazepine under conditions that promote the formation of carbamazepine/antibody immunocomplexes; and(B) determining the quantity of the drug in the liquid by measuring bound or unbound labeled drug analogue; characterized in that the labeled carbamazepine comprises:(1) a label, of the type used in immunoassays, having an amine or sulfhydryl group;(2) a carbamazepine nucleus; and(3) a linking chain linking the carboxamide group of the carbamazepine nucleus to the label, said linking chain having about 4 to about 40 atoms consisting of:(a) alkylene groups; and(b) heterocyclic ring groups, each group being joined into the linking group through chemical groups selected from(a) esters,(b) amides,(c) heteroatoms selected from --O--, --S--, and --NR--; wherein each R independently represents hydrogen or C.sub.1 to C.sub.6 alkyl; and(d) carbonyl groups.The elements of the invention are preferably dry, thin film analytical elements comprising a labeled carbamazepine analogue as described.

    摘要翻译： 描述了用于检测卡马西平药物（例如体液）的免疫测定方法和分析元件。 免疫测定方法包括：（A）在促进形成卡马西平/抗体免疫复合物的条件下，在卡马西平抗体存在下，将含有卡马西平的液体样品与标记的卡马西平类似物接触; 和（B）通过测量结合或未结合的标记药物类似物来确定液体中药物的量; 其特征在于所述标记的卡马西平包括：（1）用于免疫测定中的具有胺或巯基的类型的标签; （2）卡马西平核; 所述连接链具有约4至约40个原子，由（a）亚烷基组成;和（3）连接卡马西平核的羧酰胺基团与标记物的连接链。 每个基团通过选自（a）酯，（b）酰胺，（c）选自-O - ， - S - 和 - NR-的杂原子的化学基团连接到连接基团中; 其中每个R独立地表示氢或C1-C6烷基; 和（d）羰基。 本发明的元件优选为干燥的薄膜分析元件，其包含如上所述的标记的卡马西平类似物。

    Immunoassays with labeled thyronine hapten analogues
    4.
    发明授权
    Immunoassays with labeled thyronine hapten analogues 失效
    带有标记的甲状腺素半抗原类似物的免疫测定

    公开(公告)号：US5527709A

    公开(公告)日：1996-06-18

    申请号：US410548

    申请日：1995-03-23

    申请人： Susan J. Danielson ,  Barbara A. Brummond ,  Patricia N. Tyminski ,  Ignazio S. Ponticello

    发明人： Susan J. Danielson ,  Barbara A. Brummond ,  Patricia N. Tyminski ,  Ignazio S. Ponticello

    IPC分类号： C12N9/08 ,  G01N33/78 ,  G01N33/545

    CPC分类号： C12N9/0065 ,  G01N33/78 ,  Y10S436/817

    摘要： The invention is directed to an immunoassay for a thyronine derivative comprising:A. contacting a liquid sample, containing a thyronine derivative, with a labeled thyronine hapten analogue of the derivative in the presence of antibodies for the thyronine derivative under conditions that promote the formation of antibody-thyronine immunocomplexes; andB. determining the bound or unbound quantity of the thyronine derivative in the liquid; characterized in that the labeled thyronine derivative comprises:(i) a label, of the type used in immunoassays, having an amine or sulfhydyl group;(ii) a thyronine nucleus and(iii) a linking chain linking the label to the thyronine nucleus.

    摘要翻译： 本发明涉及一种对于神钢衍生物的免疫测定，其包括：A.在促进形成甲状腺激素的条件下，在含有甲状腺导向抗体的抗体存在下，将含有甲状腺衍生物的液体样品与衍生物的标记的甲状腺恶性半抗原类似物接触 抗体 - 甲状腺免疫复合物; 和B.确定液体中的甲状腺衍生物的结合或未结合量; 其特征在于，所述标记的甲状腺衍生物包含：（i）在免疫测定中使用的具有胺或巯基的类型的标签; （ii）神经细胞核和（iii）连接标签与陀螺质核的连接链。

    Labeled carbamazepine hapten analogues for competitive enzyme immunoassays
    5.
    发明授权
    Labeled carbamazepine hapten analogues for competitive enzyme immunoassays 失效
    标记的卡马西平半抗原类似物用于竞争性酶免疫测定

    公开(公告)号：US5543311A

    公开(公告)日：1996-08-06

    申请号：US926203

    申请日：1992-08-07

    申请人： Barbara A. Brummond ,  Mohan S. Saini ,  Ignazio S. Ponticello

    发明人： Barbara A. Brummond ,  Mohan S. Saini ,  Ignazio S. Ponticello

    IPC分类号： C07D223/22 ,  C07D403/12 ,  G01N33/535 ,  G01N33/94 ,  C12N9/96

    CPC分类号： C07D403/12 ,  C07D223/22 ,  G01N33/535 ,  G01N33/9486

    摘要： A labeled carbamazepine analogue is described comprising:(A) a label, of the type used in immunoassays, having an amine or sulfhydryl group such as horseradish peroxidase;(B) a carbamazepine nucleus; and(C) a linking chain linking the carboxamide group of the carbamazepine nucleus to the label, said linking chain having about 4 to about 40 atoms consisting of:(1) C.sub.2 to C.sub.6 alkylene groups; and(2) 5 to 7 membered heterocyclic ring groups, each group being joined into the linking group through chemical groups selected from(a) esters,(b) amides(c) heteroatoms selected from --O--, --S--, and --NR--; wherein R represents hydrogen or C.sub.1 to C.sub.6 alkyl; and(d) carbonyl.The new labeled analogues are useful in immunoassay elements and processes for detection of carbamazepine drugs, for example, in body fluids.

    摘要翻译： 描述了标记的卡马西平类似物，其包含：（A）在免疫测定中使用的具有胺或巯基的类型的标签，例如辣根过氧化物酶; （B）卡马西平核; 和（C）连接卡马西平核的羧酰胺基团与标记物的连接链，所述连接链具有约4至约40个原子，由以下组成：（1）C2至C6亚烷基; 每个基团通过选自（a）酯，（b）酰胺（c）选自-O - ， - S - 和 - 的杂原子的化学基团连接到连接基团中， NR-; 其中R表示氢或C1至C6烷基; 和（d）羰基。 新的标记的类似物可用于免疫测定元件和用于检测卡马西平药物（例如体液）的方法。