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    Flow system for pressure casting
    2.
    发明申请
    Flow system for pressure casting 审中-公开
    流压系统用于压铸

    公开(公告)号：US20070187059A1

    公开(公告)日：2007-08-16

    申请号：US10568011

    申请日：2004-08-16

    Applicant: Barrie Finnin

    Inventor： Barrie Finnin

    IPC: B22D17/08 ,  B22D17/10 ,  B22D39/00 ,  B22D37/00

    CPC classification number: B22D17/2272

    Abstract: A metal flow device, for high pressure die casting of alloys using a method or machine having, or operable to provide, a pressurised source of molten alloy and a mould defining at least one die cavity, defines a metal flow path by which alloy received from the pressurised source is able to flow into the die cavity. A first part of the length of the flow path includes or comprises a runner, while a second part of the length of the flow path from an outlet end of the runner includes a flow-path exit module (FEM). The FEM has a form which controls the alloy flow whereby the alloy flow velocity decreases progressively from the level at the outlet end of the runner whereby, at a location at which the flow path communicates with the die cavity, the alloy flow velocity is at a level significantly below the level at the outlet end of the runner and such that, on filling of the die cavity, the alloy is able to undergo solidification in the die cavity and back along the flow path towards the runner.

    Abstract translation: 金属流动装置，用于使用具有或可操作地提供熔融合金的加压源和限定至少一个模腔的模具的方法或机器的合金的高压压铸，限定了金属流动路径，通过该金属流动路径从 加压源能够流入模腔。 流路长度的第一部分包括或包括流道，而来自流道出口端的流路长度的第二部分包括流路出口模块（FEM）。 FEM具有控制合金流动的形式，由此合金流速从流道出口端处的水平逐渐降低，由此在流路与模腔连通的位置处，合金流速为 水平显着低于流道出口端处的水平，并且在填充模腔时，合金能够在模腔中经历凝固并且沿着流动路径朝向流道返回。

    Transdermal delivery rate control using amorphous pharmaceutical compositions
    5.
    发明申请
    Transdermal delivery rate control using amorphous pharmaceutical compositions 有权
    使用无定形药物组合物的透皮递送速率控制

    公开(公告)号：US20050175680A1

    公开(公告)日：2005-08-11

    申请号：US11004926

    申请日：2004-12-07

    Applicant: Timothy Morgan ,  Nina Wilkins ,  Kathryn Klose ,  Barrie Finnin ,  Barry Reed

    Inventor： Timothy Morgan ,  Nina Wilkins ,  Kathryn Klose ,  Barrie Finnin ,  Barry Reed

    IPC: A61K9/00 ,  A61K9/12 ,  A61K9/70 ,  A61K31/58

    CPC classification number: A61K31/568 ,  A61K9/0014 ,  A61K9/12 ,  A61K9/7015 ,  A61K47/14 ,  A61K47/18 ,  Y10S514/872 ,  Y10S514/874 ,  Y10S514/946 ,  Y10S514/947

    Abstract: A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent; and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (Cmax) to the average concentration (Cavg) for the physiologically active agent over the dosage interval within the range of 1 to 10.

    Abstract translation: 一种用于透皮递送的药物组合物，其包含一种或多种生理活性剂; 一种或多种皮肤渗透增强剂; 和包含挥发性溶剂的挥发性药学上可接受的载体; 并且其中所述生理活性剂和皮肤渗透增强剂在挥发性载体蒸发时形成无定形沉积物，所述无定形沉积物在角质层内形成储存器; 和（A）其中组合物具有生理活性剂的释放速率曲线，以提供最大浓度（C max）与平均浓度（C平均值）之比 >）在1〜1​​0的范围内的剂量间隔内的生理活性剂。

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