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公开(公告)号：US20110105520A1
公开(公告)日：2011-05-05
申请号：US12913966
申请日：2010-10-28
申请人： STEVEN J. COATS , HAIYAN BIAN , PETER J. CONNOLLY , GILLES BIGNAN , CHAOZHONG CAI , SCOTT L. DAX , BART L. DECORTE , SHU-CHEN LIN , LI LIU , MARK J. MACIELAG , PHILIP M. PITIS , YUE-MEI ZHANG , BIN ZHU , WEI HE
发明人： STEVEN J. COATS , HAIYAN BIAN , PETER J. CONNOLLY , GILLES BIGNAN , CHAOZHONG CAI , SCOTT L. DAX , BART L. DECORTE , SHU-CHEN LIN , LI LIU , MARK J. MACIELAG , PHILIP M. PITIS , YUE-MEI ZHANG , BIN ZHU , WEI HE
IPC分类号： A61K31/497 , C07D239/47 , C07D403/14 , A61K31/506 , A61P25/00 , A61P25/28 , A61P25/30 , A61P25/24 , A61P13/00 , A61P15/12
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3和L，A和Ra在本文中定义。
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2.发明授权4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1) 有权可用作二肽基肽酶-1（DPP-1）抑制剂的4,4-二取代哌啶衍生物公开(公告)号：US08686152B2
公开(公告)日：2014-04-01
申请号：US13043609
申请日：2011-03-09
IPC分类号： C07D409/06 , C07D405/06 , A61K31/4525 , A61K31/4535
CPC分类号： C07D409/14 , C12N5/0606
摘要： The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及4,4-二取代哌啶衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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3.发明申请公开(公告)号：US20120302541A1
公开(公告)日：2012-11-29
申请号：US13503433
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
发明人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
IPC分类号： A61K31/40 , C07D211/26 , A61K31/445 , C07D401/12 , A61K31/4439 , C07D405/12 , A61K31/4025 , C07D409/12 , C07D403/12 , A61K31/506 , C07D295/096 , A61K31/495 , C07D413/12 , A61K31/4245 , C07D451/02 , A61K31/46 , C07C217/84 , A61K31/136 , C07D205/04 , A61K31/397 , C07D453/02 , A61K31/439 , A61P29/00 , A61P19/02 , A61P25/06 , A61P11/02 , A61P13/10 , A61P17/00 , A61P11/12 , A61P25/00 , A61P25/02 , A61P1/00 , A61P35/00 , A61P25/24 , A61P25/16 , A61P25/30 , A61P25/32 , A61P13/00 , A61P15/00 , A61P1/12 , A61P9/00 , A61P11/00 , C07D207/14
CPC分类号： C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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公开(公告)号：US20110269759A1
公开(公告)日：2011-11-03
申请号：US12913986
申请日：2010-10-28
申请人： Steven J. COATS , Haiyan BIAN , Chaozhong CAI , Bart L. DECORTE , Li LIU , Mark J. MACIELAG , Scott L. DAX , Philip M. PITIS , Peter J. CONNOLLY , Wei HE
发明人： Steven J. COATS , Haiyan BIAN , Chaozhong CAI , Bart L. DECORTE , Li LIU , Mark J. MACIELAG , Scott L. DAX , Philip M. PITIS , Peter J. CONNOLLY , Wei HE
IPC分类号： A61K31/5377 , A61K31/506 , C07D413/14 , C07D403/14 , A61K31/496 , A61P19/02 , A61P25/06 , A61P25/04 , A61P13/10 , A61P17/00 , A61P1/00 , A61P35/00 , A61P29/00 , A61P25/16 , A61P25/24 , A61P25/32 , A61P9/00 , C07D401/14
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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5.发明授权公开(公告)号：US08846655B2
公开(公告)日：2014-09-30
申请号：US13503433
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
发明人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
IPC分类号： A61K31/40 , A61K31/445 , A61K31/4439 , A61K31/4025 , A61K31/506 , A61K31/495 , C07D211/56 , C07D405/12 , C07D207/09 , C07C255/50 , C07C211/48 , C07D413/12 , C07D401/12 , C07C211/50 , C07D205/04 , C07C233/08 , C07C233/11 , C07C233/65 , C07D451/04 , C07D453/02 , C07D409/12
CPC分类号： C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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公开(公告)号：US08513271B2
公开(公告)日：2013-08-20
申请号：US12913966
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
发明人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
IPC分类号： A01N43/54
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3和L，A和Ra在本文中定义。
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7.发明申请4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) 有权作为DIPPTIDYL PEPTIDASE-1（DPP-1）的抑制剂的4,4 - 取代的哌啶衍生物公开(公告)号：US20110224209A1
公开(公告)日：2011-09-15
申请号：US13043609
申请日：2011-03-09
IPC分类号： A61K31/4535 , C07D409/06 , C07D409/14 , C07D211/64 , C07D401/06 , C07D417/14 , C07D413/14 , C07D401/14 , A61K31/4545 , A61K31/451 , A61K31/454 , A61K31/445 , A61K31/5377 , A61K31/4725 , A61K31/506 , A61P29/00 , A61P11/06 , A61P11/00 , A61P1/00 , A61P9/00
CPC分类号： C07D409/14 , C12N5/0606
摘要： The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及4,4-二取代哌啶衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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