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公开(公告)号：US20070010502A1
公开(公告)日：2007-01-11
申请号：US11517593
申请日：2006-09-07
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
IPC分类号： A61K31/573 , A61K31/519
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20050187203A1
公开(公告)日：2005-08-25
申请号：US10992878
申请日：2004-11-19
申请人： Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael Slavonic , Benjamin Auspitz
发明人： Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael Slavonic , Benjamin Auspitz
IPC分类号： A61K31/4745 , A61K31/573 , C07D471/02
CPC分类号： A61K45/06 , A61K31/415 , A61K31/56 , A61K2300/00
摘要： The invention features a method for treating an immunoinflammatory administering a compound of formula (I), e.g., ibudilast or KC-764, alone or in combination with a corticosteroid, tetra-substituted pyrimidopyrimidine, or other compound. The invention also features pharmaceutical compositions including the combination above for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于一种方法，用于单独或与皮质类固醇，四取代嘧啶并嘧啶或其它化合物组合施用式（I）化合物，例如异丁司特或KC-764的免疫炎症的方法。 本发明还包括药物组合物，包括上述用于治疗或预防免疫炎性疾病的组合。
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3.发明申请公开(公告)号：US20050119160A1
公开(公告)日：2005-06-02
申请号：US10966228
申请日：2004-10-15
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
IPC分类号： A61K9/00 , A61K9/20 , A61K31/415 , A61K31/519 , A61K31/525 , A61K31/5415 , A61K31/551 , A61K31/565 , A61K31/59 , A61K31/60 , A61K38/00 , A61K38/13 , A61K45/06
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20050187200A1
公开(公告)日：2005-08-25
申请号：US10987554
申请日：2004-11-12
申请人： Benjamin Auspitz , Alexis Borisy , Jason Fong , Nicole Hurst , Edward Jost-Price , Curtis Keith , Palaniyandi Manivasakam , Robyn Sackeyfio , Michael Slavonic , Brendan Smith , Grant Zimmermann
发明人： Benjamin Auspitz , Alexis Borisy , Jason Fong , Nicole Hurst , Edward Jost-Price , Curtis Keith , Palaniyandi Manivasakam , Robyn Sackeyfio , Michael Slavonic , Brendan Smith , Grant Zimmermann
IPC分类号： A61K9/00 , A61K9/20 , A61K31/5415 , A61K31/551 , A61K31/565 , A61K31/573 , A61K31/59 , A61K31/60 , A61K38/13 , A61K45/06
CPC分类号： A61K45/06 , A61K31/565 , A61K38/13 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于一种通过向患者施用三环化合物和任选的皮质类固醇或其它化合物来治疗被诊断患有免疫炎症疾病或有风险的患者的方法。 本发明还特征在于含有三环化合物和皮质类固醇或其它化合物的药物组合物，用于治疗或预防免疫炎性疾病。
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5.发明申请Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines 审中-公开用于治疗与增加炎症细胞因子水平相关的疾病和病症的方法和试剂公开(公告)号：US20050153947A1
公开(公告)日：2005-07-14
申请号：US10947455
申请日：2004-09-20
申请人： Mahesh Padval , Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Jason Fong , Benjamin Auspitz , M. Nichols , Curtis Keith , Grant Zimmerman , Bradley Brasher , Noah Sachs , Todd Chappell
发明人： Mahesh Padval , Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Jason Fong , Benjamin Auspitz , M. Nichols , Curtis Keith , Grant Zimmerman , Bradley Brasher , Noah Sachs , Todd Chappell
IPC分类号： A61K9/00 , A61K9/20 , A61K31/00 , A61K31/565 , A61K38/13 , A61K45/06 , A61K31/573 , A61K31/137
CPC分类号： A61K45/06 , A61K9/0073 , A61K9/209 , A61K31/00 , A61K31/565 , A61K38/13 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于通过向患者施用SSRI或其类似物或代谢物，以及任选的皮质类固醇或其它化合物来治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法。 本发明还具有含有SSRI或其类似物或代谢物以及用于治疗或预防免疫炎性疾病的皮质类固醇或其他化合物的药物组合物。
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公开(公告)号：US20070110685A1
公开(公告)日：2007-05-17
申请号：US11454202
申请日：2006-06-16
申请人： Benjamin Auspitz , Bradley Brasher , Todd Chappell , Michael Frank , Daniel Grau , Edward Jost-Price , Seth Lederman , Palaniyandi Manivasakam , Seth Orlow , Noah Sachs , Brendan Smith
发明人： Benjamin Auspitz , Bradley Brasher , Todd Chappell , Michael Frank , Daniel Grau , Edward Jost-Price , Seth Lederman , Palaniyandi Manivasakam , Seth Orlow , Noah Sachs , Brendan Smith
IPC分类号： A61K8/49 , A61K38/13 , A61K31/4745 , A61K31/385 , A61K31/522 , A61K31/4178
CPC分类号： A61K45/06 , A61K31/385 , A61K31/4178 , A61K31/4523 , A61K31/4745 , A61K31/522 , A61K38/13 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and a Group A enhancer (e.g., antifungal agent, antigout agent, anti-infective agent, antiprotozoal agent, antiviral agent, humectant, sunscreen, vitamin D compound, microtubuline inhibitor, or zinc salt) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and Group A enhancer or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于一种通过施用非甾体免疫亲和素依赖性免疫抑制剂（NsIDI）和A组增强剂（例如抗真菌剂，抗原性药物，抗炎药物）治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法， 感染剂，抗原虫剂，抗病毒剂，保湿剂，防晒剂，维生素D化合物，微管免疫抑制剂或锌盐）或其类似物或代谢物。 本发明还特征在于含有NsIDI和A组增强剂或其类似物或代谢物的药物组合物，用于治疗或预防免疫炎性疾病。
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7.发明申请公开(公告)号：US20050192261A1
公开(公告)日：2005-09-01
申请号：US10940902
申请日：2004-09-14
申请人： Edward Jost-Price , Palaniyandi Manivasakam , Bradley Brasher , Brendan Smith , Noah Sachs , Benjamin Auspitz , Todd Chappell , Micheal Slavonic
发明人： Edward Jost-Price , Palaniyandi Manivasakam , Bradley Brasher , Brendan Smith , Noah Sachs , Benjamin Auspitz , Todd Chappell , Micheal Slavonic
IPC分类号： A61K31/00 , A61K31/4172 , A61K31/473 , A61K31/5415 , A61K31/573 , A61K38/13 , A61K45/06
CPC分类号： A61K45/06 , A61K31/00 , A61K31/4172 , A61K31/473 , A61K31/5415 , A61K31/573 , A61K38/13 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient an antihistamine, either alone or in combination with one or more additional agents. The invention also features a pharmaceutical composition containing an antihistamine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用单独或与一种或多种另外的试剂组合的抗组胺药来治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法。 本发明还特征在于含有抗组胺剂与一种或多种另外的药剂组合的药物组合物。
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公开(公告)号：US20060100181A1
公开(公告)日：2006-05-11
申请号：US10513237
申请日：2003-05-02
申请人： Edward Jost-Price , Palaniyandi Manivasakam , Grant Zimmermann , Jason Fong , Nicole Hurst , Benjamin Auspitz , M Nichols , Curtis Keith
发明人： Edward Jost-Price , Palaniyandi Manivasakam , Grant Zimmermann , Jason Fong , Nicole Hurst , Benjamin Auspitz , M Nichols , Curtis Keith
IPC分类号： A61K31/573 , A61K31/557
CPC分类号： A61K31/557 , A61K31/56 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The invention features methods and compositions for the treatment of inflammatory skin conditions.
摘要翻译： 本发明的特征在于用于治疗炎性皮肤病症的方法和组合物。
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9.发明申请公开(公告)号：US20070196421A1
公开(公告)日：2007-08-23
申请号：US11542211
申请日：2006-10-03
申请人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
发明人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
IPC分类号： A61F2/02 , A61K31/7048 , A61K31/7056 , A61K31/55 , A61K31/519 , A61K31/496 , A61K31/56 , A61K33/26 , A61K33/32
CPC分类号： A61F2/02 , A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K31/496 , A61K31/519 , A61K31/55 , A61K31/56 , A61K31/7048 , A61K31/7056 , A61K45/06 , A61L27/54 , A61L2300/00
摘要： Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring drug combination in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.
摘要翻译： 软组织植入物（例如，乳房，胸部，下巴，面部，唇部和鼻部植入物）与抗瘢痕形成的药物组合组合使用以抑制当将植入物置于动物体内时可能发生的瘢痕形成。
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公开(公告)号：US20070208134A1
公开(公告)日：2007-09-06
申请号：US11542185
申请日：2006-10-03
申请人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
发明人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
IPC分类号： A61K47/48
CPC分类号： A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K47/6957
摘要： The present invention provides devices or implants that comprise anti-scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fibrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
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