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公开(公告)号：US20140275003A1
公开(公告)日：2014-09-18
申请号：US14204823
申请日：2014-03-11
申请人： Paul A. Barsanti , Matthew Burger , Yan Lou , Gisele Nishiguchi , Valery Polyakov , Savithri Ramurthy , Alice Rico , Lina Setti , Aaron Smith , Benjamin Taft , Huw Tanner , Alan DiPesa , Naeem Yusuff
发明人： Paul A. Barsanti , Matthew Burger , Yan Lou , Gisele Nishiguchi , Valery Polyakov , Savithri Ramurthy , Alice Rico , Lina Setti , Aaron Smith , Benjamin Taft , Huw Tanner , Alan DiPesa , Naeem Yusuff
IPC分类号： C07D413/04 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D413/14 , C07D239/48 , A61K31/541 , C07D413/12 , C07D417/12 , C07D239/47 , C07D493/10 , C07D403/04 , C07D237/20 , C07D213/74 , C07D277/42 , C07D239/42
CPC分类号： A61K31/5377 , A61K31/444 , A61K31/501 , A61K31/5375 , A61K31/541 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/84 , C07D233/88 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D263/58 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/08 , C07D491/107 , C07D493/04 , C07D493/10 , C07D495/04 , C07D498/08 , C07D513/04
摘要： The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
摘要翻译： 本发明提供了本文所述的式（I）化合物及其盐，以及这些化合物治疗与Raf激酶活性相关的疾病的治疗用途。 本发明还提供包含这些化合物的药物组合物，以及包含这些化合物和治疗性助剂的组合物。
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公开(公告)号：US20150336960A1
公开(公告)日：2015-11-26
申请号：US14651996
申请日：2013-12-07
申请人： Matthew BURGER , Gisele NISHIGUCHI , Alice RICO , Benjamin TAFT , NOVARTIS AG
发明人： Matthew BURGER , Gisele NISHIGUCHI , Alice RICO , Benjamin TAFT
IPC分类号： C07D487/04 , A61K45/06 , A61K31/5025
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： The present invention provides a compound of formula (I) as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula (I), and pharmaceutical compositions comprising such compounds.
摘要翻译： 本发明提供本文所述的式（I）化合物及其药学上可接受的盐，对映异构体，旋转异构体，互变异构体或外消旋物。 还提供了使用式（I）的化合物治疗由PIM激酶介导的疾病或病症的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20160038504A1
公开(公告)日：2016-02-11
申请号：US14774431
申请日：2014-03-13
申请人： Robert AVERSA , Paul A. BARSANTI , Matthew BURGER , Michael Patrick DILLON , Alan DIPESA , Cheng HU , Yan LOU , Gisele NISHIGUCHI , Yue PAN , Valery POLYAKOV , Savithri RAMURTHY , Alice RICO , Lina SETTI , Aaron SMITH , Sharadha SUBRAMANIAN , Benjamin TAFT , Huw TANNER , Lifeng WAN , Naeem YUSUFF
发明人： Robert John AVERSA , Paul Andrew BARSANTI , Matthew T. BURGER , Michael Patrick DILLON , Alan DIPESA , Cheng HU , Yan LOU , Gisele A. NISHIGUCHI , Yue PAN , Valery Rostislavovich POLYAKOV , Savithri RAMURTHY , Alice C. RICO , Lina Quattrocchio SETTI , Aaron SMITH , Sharadha SUBRAMANIAN , Benjamin R. TAFT , Huw Roland TANNER , Lifeng WAN , Naeem YUSUFF
IPC分类号： A61K31/5377 , C07D401/12 , C07D413/04 , C07D413/14 , C07D239/48 , A61K31/541 , C07D401/04 , C07D413/12 , C07D417/12 , C07D239/47 , C07D491/107 , C07D403/04 , C07D498/08 , A61K31/5375 , C07D237/20 , C07D213/74 , C07D405/14 , C07D405/04 , C07D241/20 , C07D405/12 , C07D237/22 , C07D213/84 , C07D213/82 , C07D487/04 , C07D471/04 , C07D495/04 , C07D491/048 , C07D513/04 , C07D409/14 , C07D213/81 , C07D263/58 , C07D239/42
CPC分类号： A61K31/5377 , A61K31/444 , A61K31/501 , A61K31/5375 , A61K31/541 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/84 , C07D233/88 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D263/58 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/08 , C07D491/107 , C07D493/04 , C07D493/10 , C07D495/04 , C07D498/08 , C07D513/04
摘要： The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
摘要翻译： 本发明提供了本文所述的式（I）化合物及其盐，以及这些化合物治疗与Raf激酶活性相关的疾病的治疗用途。 本发明还提供包含这些化合物的药物组合物，以及包含这些化合物和治疗性助剂的组合物。
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公开(公告)号：US1756040A
公开(公告)日：1930-04-29
申请号：US40890629
申请日：1929-11-21
申请人： BENJAMIN TAFT
发明人： BENJAMIN TAFT
IPC分类号： G09F7/00
CPC分类号： G09F7/00
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