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    Quinazoline derivatives
    3.
    发明申请
    Quinazoline derivatives 审中-公开
    喹唑啉衍生物

    公开(公告)号：US20070032513A1

    公开(公告)日：2007-02-08

    申请号：US10572261

    申请日：2004-09-13

    申请人： Laurent Hennequin ,  Christopher Halsall

    发明人： Laurent Hennequin ,  Christopher Halsall

    IPC分类号： A61K31/517 ,  C07D403/02

    CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D403/14

    摘要： The invention concerns quinazoline derivatives of the Formula I: (A chemical formula should be inserted here—please see paper copy enclosed herewith) wherein each of R1, R2, W, X1, X2, Z, a and b are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula I are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.

    摘要翻译： 本发明涉及式I的喹唑啉衍生物：（化学式应在此插入，请参见随附的纸质复制品），其中R 1，R 2，W，X 1，X 2，Z，a和b各自如说明书中所定义 ; 其准备过程; 含有它们的药物组合物及其在制备用于提供抗增殖作用的药物中的用途。 预期式I的喹唑啉衍生物可用于治疗疾病，例如由erbB受体酪氨酸激酶，特别是EGFR酪氨酸激酶介导的某些癌症。

    3-Cyano-quinoline derivatives
    8.
    发明申请
    3-Cyano-quinoline derivatives 失效
    3-氰基 - 喹啉衍生物

    公开(公告)号：US20050282856A1

    公开(公告)日：2005-12-22

    申请号：US10532958

    申请日：2003-10-28

    申请人： Laurent Hennequin

    发明人： Laurent Hennequin

    IPC分类号： A61P35/00 ,  C07D405/12 ,  A61K31/4709 ,  C07D45/02

    CPC分类号： C07D405/12

    摘要： The invention concerns quinoline derivatives of Formula (I) wherein each of Z1, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.

    摘要翻译： 本发明涉及式（I）的喹啉衍生物，其中Z 1，m，R 1，n，R 3，Z， > 2 和R 14具有上文在描述中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于在实体瘤疾病的遏制和/或治疗中作为抗侵袭性或抗增殖剂的药物的用途。

    Quinazoline compounds
    9.
    发明申请
    Quinazoline compounds 失效

    公开(公告)号：US20050085465A1

    公开(公告)日：2005-04-21

    申请号：US10502538

    申请日：2003-01-28

    申请人： Laurent Hennequin

    发明人： Laurent Hennequin

    IPC分类号： C07D491/113 ,  A61K31/517 ,  A61K31/519 ,  A61P9/00 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04 ,  C07D491/04 ,  C07D519/00 ,  A61K31/541 ,  A61K31/5377

    CPC分类号： C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

    摘要： The invention relates to compounds of the formula (I): wherein ring C is as defined herein, for example indolyl, indazolyl or azaindolyl; Z is —O—, —NH— or —S—; n is 0-5; m is 0-3; R1 and R2 are defined herein including groups: (i) Q1X1 wherein Q1 and X1 are as defined herein; (ii) Q15W3 wherein Q15 and W3 are as defined herein, (iii) Q21W4C1-5alkylX1- wherein Q21, W4 and X1 are as defined herein, (iv) Q28C1-5alkylX1-, Q28C2-5alkenylX1- or Q28C2-5alkynylX1- wherein Q29 and X1 are as defined herein and (v) Q29C1-5alkylX1-, Q29C2-5alkenylX1- or Q29C2-5alkynylX1- wherein Q29 and X1 are as defined herein; R2 can also be 6,7-methylenedioxy or 6,7-ethylenedioxy; and salts thereof; their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm?blooded animals; processes for the preparation of such compounds; intermediates used in such processes; processes for making such intermediates; pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof and methods of treating disease states involving angiogenesis by administering a compound of formula I or a pharmaceutically acceptable salt thereof. The compounds of formula I inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

    Quinazoline compounds
    10.
    发明申请
    Quinazoline compounds 失效

    公开(公告)号：US20080027069A1

    公开(公告)日：2008-01-31

    申请号：US11705035

    申请日：2007-02-12

    申请人： Laurent Hennequin

    发明人： Laurent Hennequin

    IPC分类号： A61K31/517 ,  A61P35/00 ,  C07D401/14 ,  C07D471/04

    CPC分类号： C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D491/04

    摘要： The invention relates to compounds of the formula (I): wherein ring C is as defined herein, for example indolyl, indazolyl or azaindolyl; Z is —O—, —NH— or —S—; n is 0-5; m is 0-3; R1 and R2 are defined herein including groups: (i) Q1X1 wherein Q1 and X1 are as defined herein; (ii) Q15W3 wherein Q15 and W3 are as defined herein, (iii) Q21W4C1-5alkylX1— wherein Q21, W4 and X1 are as defined herein, (iv) Q28C1-5alkylX1—, Q28C2-5alkenylX1— or Q28C2-5alkynylX1— wherein Q28 and X1 are as defined herein and (v) Q29C1-5alkylX1—, Q29C2-5alkenylX1— or Q29C2-5alkynylX1— wherein Q29 and X1 are as defined herein; R2 can also be 6,7-methylenedioxy or 6,7-ethylenedioxy; and salts thereof; their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm?blooded animals; processes for the preparation of such compounds; intermediates used in such processes; processes for making such intermediates; pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof and methods of treating disease states involving angiogenesis by administering a compound of formula I or a pharmaceutically acceptable salt thereof. The compounds of formula I inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.