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公开(公告)号：US20070037837A1
公开(公告)日：2007-02-15
申请号：US10572048
申请日：2004-09-15
IPC分类号： A61K31/517
CPC分类号： C04B35/632 , A61K31/517 , C07D401/12
摘要： The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, R2, X1, R5 and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物：其中R 1，R 2，X 1，R 5， / SUP>和m具有描述中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对EGF和erbB受体酪氨酸激酶的抑制敏感的肿瘤中作为抗增殖剂的药物中的用途。
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公开(公告)号：US20070032508A1
公开(公告)日：2007-02-08
申请号：US10571851
申请日：2004-09-14
IPC分类号： A61K31/517 , C07D403/02 , C07D417/02 , C07D413/02
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D417/14
摘要： A quinazoline derivative of the formula (I); wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
摘要翻译： 式（I）的喹唑啉衍生物; 其中取代基如用于产生抗增殖作用的文本中所定义，其作用单独或部分通过在温血动物如人中抑制erbB2受体酪氨酸激酶产生。
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公开(公告)号：US20050165035A1
公开(公告)日：2005-07-28
申请号：US10857342
申请日：2004-06-01
IPC分类号： C07D401/12 , A61K31/517 , C07D43/02
CPC分类号： C07D401/12
摘要： The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB, particularly EGF, receptor tyrosine kinases.
摘要翻译： 本发明涉及式I的喹唑啉衍生物，其中R 1和R 2具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB特别是EGF受体酪氨酸激酶的抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US20050043336A1
公开(公告)日：2005-02-24
申请号：US10494137
申请日：2002-10-31
申请人： Laurent Hennequin , Jason Kettle , Martin Pass , Robert Bradbury
发明人： Laurent Hennequin , Jason Kettle , Martin Pass , Robert Bradbury
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/55 , A61P9/08 , A61P9/10 , A61P13/08 , A61P13/10 , A61P17/06 , A61P35/00 , A61P35/02 , A61P43/00 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： C07D401/12 , C07D239/94 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention concerns quinazoline derivatives of Formula (I); wherein each of Q1, Q2, Z, R1, R2, R3, and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosin kinases.
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公开(公告)号：US20070244136A1
公开(公告)日：2007-10-18
申请号：US10578663
申请日：2004-11-11
申请人： Laurent Hennequin , Robert Bradbury , Jason Kettle
发明人： Laurent Hennequin , Robert Bradbury , Jason Kettle
IPC分类号： A61K31/517 , A61P35/02 , C07D239/72
CPC分类号： C07D401/14 , C04B35/632 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.
摘要翻译： 式（I）的喹唑啉衍生物：其中取代基如用于产生抗增殖作用的文本中所定义，其作用单独或部分通过在温血动物中抑制erbB2受体酪氨酸激酶而产生， 作为人
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公开(公告)号：US20070149546A1
公开(公告)日：2007-06-28
申请号：US10554202
申请日：2004-04-20
申请人： Robert Bradbury , Jason Kettle
发明人： Robert Bradbury , Jason Kettle
IPC分类号： A61K31/517 , C07D417/02 , C07D413/02 , C07D403/02 , C07D239/94
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D413/12 , C07D417/12
摘要： A quinazsoline derivative of the formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrxosine kinase in a warm blooded animnal such as man.
摘要翻译： 式（I）的喹唑啉衍生物：其中取代基如用于产生抗增殖作用的文本中所定义，其作用单独或部分通过在温血动物中抑制erbB2受体酪氨酸激酶产生，例如 人。
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公开(公告)号：US20070088044A1
公开(公告)日：2007-04-19
申请号：US11443395
申请日：2006-05-31
申请人： Laurent Hennequin , Jason Kettle , Martin Pass , Robert Bradbury
发明人： Laurent Hennequin , Jason Kettle , Martin Pass , Robert Bradbury
IPC分类号： A61K31/517 , C07D403/02 , C07D239/94
CPC分类号： C04B35/632 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention concerns quinazoline derivatives of Formula (I); wherein each of Q , Q , Z, R , R , R , and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosin kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物; 其中Q 1，Q 2，Z，R 1，R 2，R 3和m各自具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对抑制erbB受体酪氨酸激酶敏感的肿瘤的药物中的用途。
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公开(公告)号：US20070015743A1
公开(公告)日：2007-01-18
申请号：US10572262
申请日：2004-09-14
申请人： Robert Bradbury , Jason Kettle , Laurent Hennequin
发明人： Robert Bradbury , Jason Kettle , Laurent Hennequin
IPC分类号： A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/517 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/14
摘要： A quinazoline derivative of the formula (I): (A chemical formula should be inserted here—please see paper copy enclosed) Formula I wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
摘要翻译： 式（I）的喹唑啉衍生物：（在此应插入化学式 - 请参见附有复印件）式I其中取代基如用于产生抗增殖效应的文本中所定义，其产生效果 单独或部分通过在温血动物如人中抑制erbB2受体酪氨酸激酶。
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公开(公告)号：US20050215574A1
公开(公告)日：2005-09-29
申请号：US10508675
申请日：2003-03-26
IPC分类号： C07D491/056 , A61K31/517 , A61K31/5377 , A61P9/10 , A61P13/08 , A61P17/06 , A61P35/00 , A61P35/02 , A61P43/00 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D491/04
CPC分类号： C07D401/12 , C07D403/12
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
摘要翻译： 本发明涉及式（I）的喹唑啉衍生物，其中Q 1，Z，R 1和Q 2 2中的每一个具有定义的任何含义 在说明中; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB受体酪氨酸激酶抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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公开(公告)号：US20070099943A1
公开(公告)日：2007-05-03
申请号：US11636549
申请日：2006-12-11
IPC分类号： A61K31/517 , C07D403/02
CPC分类号： C04B35/632 , C07D401/12
摘要： The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB, particularly EGF, receptor tyrosine kinases.
摘要翻译： 本发明涉及式I的喹唑啉衍生物，其中R 1和R 2具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB特别是EGF受体酪氨酸激酶的抑制敏感的肿瘤中的抗增殖剂的药物中的用途。
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