公开(公告)号：US09012227B2

公开(公告)日：2015-04-21

申请号：US12742318

申请日：2008-12-12

申请人： Andreas Karau ,  Volker Sieber ,  Thomas Haas ,  Harald Haeger ,  Katrin Grammann ,  Bruno Buehler ,  Lars Blank ,  Andreas Schmid ,  Guido Jach ,  Bernd Lalla ,  Andreas Mueller ,  Katrin Schullehner ,  Peter Welters ,  Thorsten Eggert ,  Andrea Weckbecker

发明人： Andreas Karau ,  Volker Sieber ,  Thomas Haas ,  Harald Haeger ,  Katrin Grammann ,  Bruno Buehler ,  Lars Blank ,  Andreas Schmid ,  Guido Jach ,  Bernd Lalla ,  Andreas Mueller ,  Katrin Schullehner ,  Peter Welters ,  Thorsten Eggert ,  Andrea Weckbecker

IPC分类号： C12N15/74 ,  C12N15/00 ,  C12N15/52 ,  C08G69/08 ,  C08G69/14 ,  C12P13/00

CPC分类号： C12N15/52 ,  C08G69/08 ,  C08G69/14 ,  C12P13/005

摘要： The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ω-aminocarboxylic acids, more ω-aminocarboxylic acid esters or more lactams derived from ω-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ω-aminocarboxylic acids, of ω-aminocarboxylic acid esters or of lactams derived from ω-aminocarboxylic acids, the ω-aminocarboxylic acids, ω-aminocarboxylic acid esters or lactams derived from ω-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ω-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.

摘要翻译： 本发明涉及一种相对于其野生型经遗传修饰的细胞，因此与野生型相比，能够产生更多的ω-氨基羧酸，更多的ω-氨基羧酸酯或更多来源于ω的内酰胺 氨基羧酸，起始于羧酸或羧酸酯。 此外，本发明涉及生产转基因细胞的方法，可通过该方法获得的细胞，ω-氨基羧酸酯或ω-氨基羧酸衍生的内酰胺的生产ω-氨基羧酸的方法 酸，ω-氨基羧酸，ω-氨基羧酸酯或衍生自可通过该方法得到的ω-氨基羧酸的内酰胺，制备基于ω-氨基羧酸或基于内酰胺的聚酰胺的方法和可通过该方法获得的聚酰胺 。

公开(公告)号：US20100324257A1

公开(公告)日：2010-12-23

申请号：US12742318

申请日：2008-12-12

申请人： Andreas Karau ,  Volker Sieber ,  Thomas Haas ,  Harald Haeger ,  Katrin Grammann ,  Bruno Buehler ,  Lars Blank ,  Andreas Schmid ,  Guido Jach ,  Bernd Lalla ,  Andreas Mueller ,  Katrin Schullehner ,  Peter Welters ,  Thorsten Eggert ,  Andrea Weckbecker

发明人： Andreas Karau ,  Volker Sieber ,  Thomas Haas ,  Harald Haeger ,  Katrin Grammann ,  Bruno Buehler ,  Lars Blank ,  Andreas Schmid ,  Guido Jach ,  Bernd Lalla ,  Andreas Mueller ,  Katrin Schullehner ,  Peter Welters ,  Thorsten Eggert ,  Andrea Weckbecker

IPC分类号： C08G69/08 ,  C12N1/00 ,  C12N1/21 ,  C12P13/00 ,  C12P17/10 ,  C07C229/00 ,  C07D225/00 ,  C08G73/06

CPC分类号： C12N15/52 ,  C08G69/08 ,  C08G69/14 ,  C12P13/005

摘要： The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ω-aminocarboxylic acids, more ω-aminocarboxylic acid esters or more lactams derived from ω-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ω-aminocarboxylic acids, of ω-aminocarboxylic acid esters or of lactams derived from ω-aminocarboxylic acids, the ω-aminocarboxylic acids, ω-aminocarboxylic acid esters or lactams derived from ω-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ω-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.

摘要翻译： 本发明涉及一种相对于其野生型经遗传修饰的细胞，因此与野生型相比，能够产生更多的ω-氨基羧酸，更多的ω-氨基羧酸酯或更多来源于ω的内酰胺 氨基羧酸，起始于羧酸或羧酸酯。 此外，本发明涉及生产转基因细胞的方法，可通过该方法获得的细胞，ω-氨基羧酸酯或ω-氨基羧酸衍生的内酰胺的生产ω-氨基羧酸的方法 酸，ω-氨基羧酸，ω-氨基羧酸酯或衍生自可通过该方法得到的ω-氨基羧酸的内酰胺，制备基于ω-氨基羧酸或基于内酰胺的聚酰胺的方法和可通过该方法获得的聚酰胺 。